Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Timothy R. Hughes"'
Autor:
Nguyen N. T. Vo, Ally Yang, Wiphawee Leesutthiphonchai, Yulong Liu, Timothy R. Hughes, Howard S. Judelson
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Identifying the DNA-binding specificities of transcription factors (TF) is central to understanding gene networks that regulate growth and development. Such knowledge is lacking in oomycetes, a microbial eukaryotic lineage within
Externí odkaz:
https://doaj.org/article/f13c9a9855834dfbb5e371a09c6465d4
Autor:
Debashish Ray, Kaitlin U. Laverty, Arttu Jolma, Kate Nie, Reuben Samson, Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk, Syed Nabeel-Shah, Mihai Albu, Hong Zheng, Gabrielle Perron, Hyunmin Lee, Hamed Najafabadi, Benjamin Blencowe, Jack Greenblatt, Quaid Morris, Timothy R. Hughes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Thousands of RNA-binding proteins (RBPs) crosslink to cellular mRNA. Among these are numerous unconventional RBPs (ucRBPs)—proteins that associate with RNA but lack known RNA-binding domains (RBDs). The vast majority of ucRBPs have unchara
Externí odkaz:
https://doaj.org/article/1bc102f75ce84e278ddced7e0d6825bd
Autor:
Morgane Mazzarino, Esra Cetin, Maria Bartosova, Iva Marinovic, Natacha Ipseiz, Timothy R. Hughes, Claus Peter Schmitt, Dipak P. Ramji, Mario O. Labéta, Anne-Catherine Raby
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chronic Kidney Disease (CKD) is associated with markedly increased cardiovascular (CV) morbidity and mortality. Chronic inflammation, a hallmark of both CKD and CV diseases (CVD), is believed to drive this association. Pro-inflammatory endogenous TLR
Externí odkaz:
https://doaj.org/article/3289f0a2df684724b686b25645161512
Autor:
Sarah M. Carpanini, Megan Torvell, Ryan J. Bevan, Robert A. J. Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C. Saido, Philip R. Taylor, Timothy R. Hughes, Wioleta M. Zelek, B. Paul Morgan
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer’s disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments then tag them for microglial phagocytosi
Externí odkaz:
https://doaj.org/article/c1e6f35fb3074c2aa60306724f5fa309
Autor:
Zain M. Patel, Timothy R. Hughes
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Mammalian genomes contain millions of putative regulatory sequences, which are delineated by binding of multiple transcription factors. The degree to which spacing and orientation constraints among transcription factor binding sit
Externí odkaz:
https://doaj.org/article/6afaa32e24704d45aab9bc469aa7a993
Autor:
Thomas S. Webberley, Giulia Masetti, Ryan J. Bevan, Joshua Kerry-Smith, Alison A. Jack, Daryn R. Michael, Sophie Thomas, Maria Glymenaki, Jia Li, Julie A. K. McDonald, Daniel John, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Timothy R. Hughes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Brain degenerative disorders such as Alzheimer’s disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising preventative strategy for both neurodegeneration and metabolic syndrome. In
Externí odkaz:
https://doaj.org/article/77eda7a758794348b5e35fc83931f5f5
Autor:
Thomas S. Webberley, Ryan J. Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R. Michael, Sophie Thomas, Meg Rees, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Duolao Wang, Timothy R. Hughes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4683 (2023)
Aging and metabolic syndrome are associated with neurodegenerative pathologies including Alzheimer’s disease (AD) and there is growing interest in the prophylactic potential of probiotic bacteria in this area. In this study, we assessed the neuropr
Externí odkaz:
https://doaj.org/article/e72309a117a74e4c84fcf9c17609b021
Autor:
Adam Kosti, Patricia Rosa de Araujo, Wei-Qing Li, Gabriela D. A. Guardia, Jennifer Chiou, Caihong Yi, Debashish Ray, Fabiana Meliso, Yi-Ming Li, Talia Delambre, Mei Qiao, Suzanne S. Burns, Franziska K. Lorbeer, Fanny Georgi, Markus Flosbach, Sarah Klinnert, Anne Jenseit, Xiufen Lei, Carolina Romero Sandoval, Kevin Ha, Hong Zheng, Renu Pandey, Aleksandra Gruslova, Yogesh K. Gupta, Andrew Brenner, Erzsebet Kokovay, Timothy R. Hughes, Quaid D. Morris, Pedro A. F. Galante, Stefano Tiziani, Luiz O. F. Penalva
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-32 (2020)
Abstract Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Ident
Externí odkaz:
https://doaj.org/article/351c24c3b258441fade10ab7e34c510d
Autor:
Thomas S. Webberley, Giulia Masetti, Laura M. Baker, Jordanna Dally, Timothy R. Hughes, Julian R. Marchesi, Alison A. Jack, Sue F. Plummer, Guru Ramanathan, Paul D. Facey, Daryn R. Michael
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
The anti-inflammatory and cholesterol lowering capabilities of probiotic bacteria highlight them as potential prophylactics against chronic inflammatory diseases, particularly cardiovascular disease. Previous studies in silico, in vitro, and in vivo
Externí odkaz:
https://doaj.org/article/ea4801e0729649bd94e425beaf15c7f5
Autor:
Florine Seidel, Robert Kleemann, Wim van Duyvenvoorde, Nikki van Trigt, Nanda Keijzer, Sandra van der Kooij, Cees van Kooten, Lars Verschuren, Aswin Menke, Amanda J. Kiliaan, Johnathan Winter, Timothy R. Hughes, B. Paul Morgan, Frank Baas, Kees Fluiter, Martine C. Morrison
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10736 (2022)
Background: Chronic inflammation is an important driver in the progression of non-alcoholic steatohepatitis (NASH) and atherosclerosis. The complement system, one of the first lines of defense in innate immunity, has been implicated in both diseases.
Externí odkaz:
https://doaj.org/article/8ac9af891c33464eae515a193ee5e899