Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy R. Howard"'
Publikováno v:
mSystems, Vol 7, Iss 3 (2022)
ABSTRACT Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors. The interferon-inducible protein 16 (IFI16) is a nuclear DNA sensor that recognizes
Externí odkaz:
https://doaj.org/article/11b21f52a22341659dd3decf733742de
Publikováno v:
mSystems, Vol 6, Iss 3 (2021)
Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.
Externí odkaz:
https://doaj.org/article/298b9a6dd03e46b69912ca7d1a027da4
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The formation of multimerized protein assemblies has emerged as a core component of immune signal amplification, yet the biochemical basis of this phenomenon remains unclear for many mammalian proteins within host defense pathways. The inter
Externí odkaz:
https://doaj.org/article/80cf4c532bf4458f95d35ee1f2e48a2c
Autor:
Timothy R. Howard, Ileana M. Cristea
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1591 (2020)
Nuclear DNA sensors are critical components of the mammalian innate immune system, recognizing the presence of pathogens and initiating immune signaling. These proteins act in the nuclei of infected cells by binding to foreign DNA, such as the viral
Externí odkaz:
https://doaj.org/article/7a3337dd108f46c586f03be1b0ac6228
Publikováno v:
mSystems, Vol 6, Iss 3 (2021)
mSystems
mSystems
DNA sensors are critical components of innate immunity that enable cells to recognize infection by pathogens with DNA genomes. The interferon-inducible protein X (IFIX), a member of the PYHIN protein family, is a DNA sensor capable of promoting immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4125f659d2450784ec7e4905badc0ce
https://doi.org/10.1128/msystems.00397-21
https://doi.org/10.1128/msystems.00397-21
Publikováno v:
Methods in enzymology. 625
DNA sensors are a core component of innate immunity in mammalian cells. In response to pathogen infection, these specialized proteins sense pathogenic DNA from bacteria or viruses and initiate immune signaling cascades. These defense mechanisms rely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230bb0cdb205deb33181ebd53b36d25c
https://pubmed.ncbi.nlm.nih.gov/31455534
https://pubmed.ncbi.nlm.nih.gov/31455534
Autor:
Krystal K. Lum, Benjamin A. Diner, Ileana M. Cristea, Joel D. Federspiel, Bokai Song, Timothy R. Howard
Publikováno v:
Cell Systems. 7:627-642.e6
Summary Viral DNA sensing is an essential component of the mammalian innate immune response. Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of cyclic dinucleotides to induce type I interferons. However, little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82702b585b26ddd722b2cbf0c4fa7d4
https://doi.org/10.1016/j.cels.2018.10.010
https://doi.org/10.1016/j.cels.2018.10.010