Výsledky vyhledávání - "Timothy R. Hare"

The Use of SSMD-Based False Discovery and False Nondiscovery Rates in Genome-Scale RNAi Screens

Autor: Marc Ferrer, Joel P. Berger, Joseph F. Heyse, Alex McCampbell, Daniel J. Holder, Shane Marine, Timothy R. Hare, Dawn Toolan, Ruojing Yang, Joleen Kajdas, Xiaohua Douglas Zhang, Raul Lacson

Publikováno v: SLAS Discovery. 15:1123-1131

In genome-scale RNA interference (RNAi) screens, it is critical to control false positives and false negatives statistically. Traditional statistical methods for controlling false discovery and false nondiscovery rates are inappropriate for hit selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2647342705c4e38b0f67567228b167
https://doi.org/10.1177/1087057110381919

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Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position

Publikováno v: Journal of Medicinal Chemistry. 40:3726-3733

A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (Ki 0.8-12 nM), 300-1500-fold selectivity for thrombin compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9c3eb4d8f15436d50d759edace5a6
https://doi.org/10.1021/jm970493r

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Vampire Bat Salivary Plasminogen Activator Evokes Minimal Bleeding Relative to Tissue-Type Plasminogen Activator as Assessed by a Rabbit Cuticle Bleeding Time Model

Autor: M J Mellott, Edith T. Senderak, Denise R Ramjit, Joseph J. Lynch, Inez I. Stabilito, Stephen J. Gardell, Timothy R. Hare

Publikováno v: Thrombosis and Haemostasis. 73:478-483

SummaryCuticle bleeding time (CBT) measurements in anesthetized rabbits were performed to assess the potential bleeding risks which may accompany the administration of tissue-type plasminogen activator (tPA) or vampire bat salivary plasminogen activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::882f605acb8b3e25bfa6e2cbbee16377
https://doi.org/10.1055/s-0038-1653800

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Vampire Bat Salivary Plasminogen Activator Promotes Robust Lysis of Plasma Clots in a Plasma Milieu Without Causing Fluid Phase Plasminogen Activation

Autor: Timothy R. Hare, Stephen J. Gardell

Publikováno v: Thrombosis and Haemostasis. 68:165-169

SummaryVampire bat salivary plasminogen activator (BatPA), human tissue-type plasminogen activator (tPA) or streptokinase (SK) were incubated in human citrated plasma containing a plasma clot that was radiolabelled with iodine-125 fibrin(ogen). Compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::631728818d1c7ca007eac0034e0d770b
https://doi.org/10.1055/s-0038-1656343

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Multiplexed assays by high-content imaging for assessment of GPCR activity

Autor: S. Vaidya, K. Alves, Timothy R. Hare, David A. Ross, S. Lee, Berta Strulovici, Rebecca Mull, J. Xue, Francesca Santini, Marc Ferrer, P.A. Detmers, Anthony Kreamer, Edward Hudak, V. Reiser, Russell B. Lingham

Publikováno v: Journal of biomolecular screening. 13(6)

G-protein-coupled receptors (GPCR) participate in many disease pathways and represent the largest family of therapeutic targets. Thus, great investments are made to discover drugs modulating GPCR-mediated events. Among functional assays for screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180876d19145aa2388c609df83efb20c
https://pubmed.ncbi.nlm.nih.gov/18519922

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Vampire bat salivary plasminogen activator is quiescent in human plasma in the absence of fibrin unlike human tissue plasminogen activator

Autor: Stephen J. Gardell, Gregory C. Cuca, Susan M. Zavodny, Linda O’Neill-Palladino, Peter W. Bergum, Timothy R. Hare

Publikováno v: Blood. 76:2560-2564

The vampire bat salivary plasminogen activator (Bat-PA) is a potent PA that exhibits remarkable selectivity toward fibrin-bound plasminogen (Gardell et al, J Biol Chem 256: 3568, 1989). Herein, we describe the activity of recombinant DNA-derived Bat-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff613a82c98616a90bf5bfa1185077e6
https://doi.org/10.1182/blood.v76.12.2560.2560

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Purification and characterization of human plasminogen activator inhibitor type I expressed in Saccharomyces cerevisiae

Autor: Schultz Loren D, Henry Z. Markus, Ronald W. Ellis, Timothy R. Hare, Stephen J. Gardell, Jang H. Han, Christine E. Carty, Bernice J. Keech

Publikováno v: Archives of Biochemistry and Biophysics. 278:467-474

The rapidly acting inhibitor of plasminogen activators, PAI-1, was produced intracellularly in Saccharomyces cerevisiae by using the ADH2 promoter to drive the expression of the human PAI-1 cDNA. Approximately 8 mg of human PAI-1 was produced per lit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb52441f4e117785c0f5e98c4e043d30
https://doi.org/10.1016/0003-9861(90)90286-8

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Additional fucosyl residues on membrane glycoproteins but not a secreted glycoprotein from cystic fibrosis fibroblasts

Autor: Karl Hård, Johannes F.G. Vliegenthart, Bokran Won, Yu-Mei Wang, Mary Catherine Glick, Christopher P. Stowell, Timothy R. Hare, J. Albert van Kuik, Thomas F. Scanlin

Publikováno v: Clinica Chimica Acta. 188:193-210

Glycopeptides derived from peripheral membrane glycoproteins of skin fibroblasts of seven patients with cystic fibrosis (CF) had an increase in fucosyl residues when compared with those of seven age, race and sex matched controls (Pediatr Res 1985;19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a68817588caf0e6e58ca552c1b24f6
https://doi.org/10.1016/0009-8981(90)90201-3

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Isolation, characterization, and cDNA cloning of a vampire bat salivary plasminogen activator

Autor: R B Register, Timothy R. Hare, Richard A. F. Dixon, Le T. Duong, R E Diehl, John W. Jacobs, John D. York, Paul A. Friedman, S. J. Gardell

Publikováno v: Journal of Biological Chemistry. 264:17947-17952

Vampire bat saliva contains a plasminogen activator that presumably assists these hematophagous animals during feeding. Here, we report that the vampire bat salivary plasminogen activator, Bat-PA, is homologous to tissue-type plasminogen activator (t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8429bcdbe2ac4c91b5aa1d5973f9aae3
https://doi.org/10.1016/s0021-9258(19)84664-1

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