Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Timothy R. Geistlinger"'
Autor:
Myles Brown, Donald P. McDonnell, Edward K. Lobenhofer, Mathieu Lupien, Matthew L. Eaton, Deborah C. Otteson, Timothy R. Geistlinger, Wencheng Zhu, Michelle S. Jansen, Joseph R. Nevins, Sakiko Kobayashi, Hilary E. Wade
Publikováno v:
Molecular and Cellular Biology. 30:1866-1877
An analysis of mRNA expression in T47D breast cancer cells treated with the synthetic progestin R5020 revealed a subset of progesterone receptor (PR) target genes that are enriched for E2F binding sites. Following up on this observation, we determine
Autor:
Thomas R. Gingeras, Wei Li, Jérôme Eeckhoute, X. Shirley Liu, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Giles Hall, Edward A. Fox, Pamela A. Silver, Jun S. Song, Alexander S. Brodsky, Clifford A. Meyer, Kirsten C Fertuck, Timothy R. Geistlinger, Erika Krasnickas Keeton, Jason S. Carroll, Myles Brown
Publikováno v:
Nature Genetics. 38:1289-1297
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the
Autor:
Maria I. Torres-Arzayus, Jason S. Carroll, Myles Brown, Timothy R. Geistlinger, Jérôme Eeckhoute
Publikováno v:
Genes & Development. 20:2513-2526
Estrogen stimulates the proliferation of the most common type of human breast cancer that expresses estrogen receptor α (ERα) through the activation of the cyclin D1 (CCND1) oncogene. However, our knowledge of ERα transcriptional mechanisms remain
Autor:
Clifford A. Meyer, Eli V. Hestermann, Timothy R. Geistlinger, Anna J. Szary, Edward A. Fox, Myles Brown, Jason S. Carroll, Alexander S. Brodsky, Wei Li, Wenlin Shao, Pamela A. Silver, X. Shirley Liu, Jérôme Eeckhoute
Publikováno v:
Cell. 122(1):33-43
SummaryEstrogen plays an essential physiologic role in reproduction and a pathologic one in breast cancer. The completion of the human genome has allowed the identification of the expressed regions of protein-coding genes; however, little is known co
Publikováno v:
Chemistry & Biology. 11:273-281
Ligand-dependent nuclear hormone receptor (NR) signaling requires direct interaction between NR and the steroid receptor coactivators (SRC). Herein we utilize a library of SRC2 peptidomimetics to select for specific inhibitors of the interaction of S
Autor:
William J. Howat, Antoni Hurtado, Robert Ian Nicholson, Iain Robert Hutcheson, Simak Ali, Kelly A. Holmes, Jie Jiang, Jason S. Carroll, Timothy R. Geistlinger, Myles Brown
Publikováno v:
Nature. 456(7222)
Crosstalk between the oestrogen receptor (ER) and ERBB2/HER-2 pathways has long been implicated in breast cancer aetiology and drug response1, yet no direct connection at a transcriptional level has been shown. Here we show that oestrogen–ER and ta
Autor:
R. Kiplin Guy, Timothy R. Geistlinger
Publikováno v:
Journal of the American Chemical Society. 125(23)
Nuclear hormone receptor (NR) signaling, currently a therapeutic target in multiple diseases, involves an ordered series of protein interactions to regulate transcription in response to changing hormone levels. Later steps in the process of ligand-de
Autor:
Timothy R. Geistlinger, R. Kiplin Guy
Publisher Summary This chapter focuses on the methods that are useful for designing and synthesizing a series of coactivator peptidomimetics (axXXbxcx) of the L1XXL2L3 sequence to identify specific inhibitors of particular hormone receptor (NR)–coa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45087cac378ceffb4069f49024a96eba
https://doi.org/10.1016/s0076-6879(03)64013-9
https://doi.org/10.1016/s0076-6879(03)64013-9
Autor:
Timothy R. Geistlinger, Guy Rk
Publikováno v:
Journal of the American Chemical Society. 123:1525-1526
Autor:
Jie Jiang, Kelly A. Holmes, Myles Brown, Jason S. Carroll, Timothy R. Geistlinger, Robert Ian Nicholson, Iain Robert Hutcheson, William J. Howat, Antoni Hurtado, Simak Ali
Publikováno v:
Nature. 457:1168-1168
Nature 456, 663–666 (2008) In the Methods Summary, online-only Methods and the legend to Supplementary Fig. 16, the antibody catalogue number for the PAX2 antibody was incorrectly listed as ab38738. The correct antibody used for PAX2 immunohistoche