Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Timothy R. Blake"'
Autor:
Ole A. W. Haabeth, Julian J. K. Lohmeyer, Adrienne Sallets, Timothy R. Blake, Idit Sagiv-Barfi, Debra K. Czerwinski, Blaine McCarthy, Abigail E. Powell, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Publikováno v:
ACS Central Science, Vol 7, Iss 7, Pp 1191-1204 (2021)
Externí odkaz:
https://doaj.org/article/86bb0ef635a54b0b80cf96a5c31c42a3
Autor:
Stefano Testa, Ole A. W. Haabeth, Timothy R. Blake, Trevor J. Del Castillo, Debra K. Czerwinski, Ranjani Rajapaksa, Paul A. Wender, Robert M. Waymouth, Ronald Levy
Publikováno v:
Biomacromolecules
Charge-altering releasable transporters (CARTs) are a class of oligonucleotide delivery vehicles shown to be effective for delivery of messenger RNA (mRNA) both in vitro and in vivo. Here, we exploited the chemical versatility of the CART synthesis t
Autor:
Ronald Levy, Paul A. Wender, Robert M. Waymouth, Adrienne Sallets, Anders A. Tveita, Colin J. McKinlay, Timothy R. Blake, Ole Audun Werner Haabeth
OX40L, CD80 and CD86 mRNA-CART treatment increased the expression of CD80, CD86 and OX40L protein on tumor infiltrating cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e930294fe3e506b8c8b7e415ac16e1f5
https://doi.org/10.1158/0008-5472.22422302
https://doi.org/10.1158/0008-5472.22422302
Autor:
Ronald Levy, Paul A. Wender, Robert M. Waymouth, Adrienne Sallets, Anders A. Tveita, Colin J. McKinlay, Timothy R. Blake, Ole Audun Werner Haabeth
Localized expression of effector molecules can initiate antitumor responses through engagement of specific receptors on target cells in the tumor microenvironment. These locally induced responses may also have a systemic effect, clearing additional t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35adde64007d6fb68bfae2143b49ed9
https://doi.org/10.1158/0008-5472.c.6511175
https://doi.org/10.1158/0008-5472.c.6511175
Autor:
Ronald Levy, Paul A. Wender, Robert M. Waymouth, Adrienne Sallets, Anders A. Tveita, Colin J. McKinlay, Timothy R. Blake, Ole Audun Werner Haabeth
Supplementary Figure S2. OX40L, CD80 and CD86 mRNA-CART treatment induce long lasting protection against re-challenge with the same tumor cell line. Supplementary Figure S3. OX40L, CD80 and CD86 mRNA-CART treatment do not result in long term elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0194fcd4d92fb36342de29c74ad03b3b
https://doi.org/10.1158/0008-5472.22422305
https://doi.org/10.1158/0008-5472.22422305
Autor:
Timothy R. Blake, Ole A. W. Haabeth, Adrienne Sallets, Rebecca L. McClellan, Trevor J. Del Castillo, Jose G. Vilches-Moure, Wilson C. Ho, Paul A. Wender, Ronald Levy, Robert M. Waymouth
Publikováno v:
Bioconjugate Chemistry.
Autor:
Melanie A. Huttner, Robert M. Waymouth, Timothy R. Blake, Xiaoyu Zang, Wilson C. Ho, Paul A. Wender, Christopher R Turlington
Publikováno v:
Chemical Science
The synthesis and degradation mechanisms of a class of pH-sensitive, rapidly degrading cationic poly(α-aminoester)s are described. These reactive, cationic polymers are stable at low pH in water, but undergo a fast and selective degradation at highe
Autor:
Maryam Habibian, Robert M. Waymouth, Paul A. Wender, Anna M. Kietrys, Colin J. McKinlay, Timothy R. Blake, Eric T. Kool
Publikováno v:
Chemical Science
We report the development of post-transcriptional chemical methods that enable control over CRISPR–Cas9 gene editing activity both in in vitro assays and in living cells. We show that an azide-substituted acyl imidazole reagent (NAI-N3) efficiently
Autor:
Abigail E. Powell, Timothy R. Blake, Robert M. Waymouth, Blaine G. McCarthy, Idit Sagiv-Barfi, Julian J K Lohmeyer, Adrienne Sallets, Ronald Levy, Ole Audun Werner Haabeth, Debra K. Czerwinski, Paul A. Wender
Publikováno v:
ACS Central Science, Vol 7, Iss 7, Pp 1191-1204 (2021)
ACS Central Science
bioRxiv
ACS Central Science
bioRxiv
The SARS-CoV-2 pandemic has necessitated the rapid development of prophylactic vaccines. Two mRNA vaccines have been approved for emergency use by the FDA and have demonstrated extraordinary effectiveness. The success of these mRNA vaccines establish
Autor:
Timothy R. Blake, Anders Aune Tveita, Robert M. Waymouth, Adrienne Sallets, Paul A. Wender, Colin J. McKinlay, Ole Audun Werner Haabeth, Ronald Levy
Publikováno v:
Cancer Research. 79:1624-1634
Localized expression of effector molecules can initiate antitumor responses through engagement of specific receptors on target cells in the tumor microenvironment. These locally induced responses may also have a systemic effect, clearing additional t