Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Timothy R. Zacharewski"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with metabolic syndrome (MetS) in humans and elicits pathologies in rodents that resemble non-alcoholic fatty liver disease (NAFLD) in humans through activation of the aryl hydrocarbon
Externí odkaz:
https://doaj.org/article/6ca555dc30684b499a04f452103b3251
Autor:
Giovan N. Cholico, Russell R. Fling, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized peripheral fats, inhibiting lipoprotein export, and repressing β-oxidation. In this
Externí odkaz:
https://doaj.org/article/c45e1cdb4ce34f019fc7bb449eff6b5a
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Abstract Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines the effects of
Externí odkaz:
https://doaj.org/article/9a17274562514ae6a763ae55659ce0bb
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12431 (2021)
Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. TCDD induces
Externí odkaz:
https://doaj.org/article/41119752f628489ea5a9b3ddd7de6fcb
Publikováno v:
Chemical Research in Toxicology.
Autor:
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice orally gavaged with TCDD (0.01–30 µg/kg) every
Externí odkaz:
https://doaj.org/article/dfa70fdef3ce4540b2a3007793bde343
Autor:
David W. Threadgill, Peter Dornbos, Rance Nault, Amanda Jurgelewicz, Melanie Warren, Hui Lin, Anooj A Arkatkar, Timothy R. Zacharewski, John J. LaPres
Publikováno v:
Toxicol Sci
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor in the Per-Arnt-Sim superfamily of environmental sensors that is linked to several metabolic diseases, including nonalcoholic fatty liver disease. Much remains unknown reg
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 147-159 (2021)
Background and Aims Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)typ
Autor:
Sudin Bhattacharya, Timothy R. Zacharewski, Norbert E. Kaminski, Edward Dere, Melvin E. Andersen, Navya Shilpa Josyula
Publikováno v:
Archives of Toxicology. 94:113-126
Four decades after its discovery, the aryl hydrocarbon receptor (AHR), a ligand-inducible transcription factor (TF) activated by the persistent environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), remains an enigmatic molecule with a
Autor:
Timothy R. Zacharewski, Sudin Bhattacharya, Satabdi Saha, Tapabrata Maiti, Rance Nault, Jack P. Dodson, Samiran Sinha
The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and toxicological responses. Current differential ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f7ca2dc65fc503bf5eb1a8f978b11d
https://doi.org/10.1101/2021.09.08.459475
https://doi.org/10.1101/2021.09.08.459475