Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Timothy R Rosean"'
Autor:
Sara M Reed, Jussara Hagen, Viviane P Muniz, Timothy R Rosean, Nick Borcherding, Sebastian Sciegienka, J Adam Goeken, Paul W Naumann, Weizhou Zhang, Van S Tompkins, Siegfried Janz, David K Meyerholz, Dawn E Quelle
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112126 (2014)
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor of cell proliferation that helps maintain chromosomal stability. It is a novel activator of the ARF-Mdm2-Tip60-p53 tumor suppressor pathway as well as
Externí odkaz:
https://doaj.org/article/9c544ff0f4564561a32fe2479115b285
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65599 (2013)
Tumor metastasis plays a major role in the morbidity and mortality of cancer patients. Among solid tumors that undergo metastasis, there is often a predilection to metastasize to a particular organ with, for example, prostate cancer preferentially me
Externí odkaz:
https://doaj.org/article/72f802d1b3f6426d8ad001bfc1ca63aa
Autor:
Lyse A Norian, Timothy P Kresowik, Henry M Rosevear, Britnie R James, Timothy R Rosean, Andrew J Lightfoot, Tamara A Kucaba, Christopher Schwarz, Christine J Weydert, Michael D Henry, Thomas S Griffith
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31085 (2012)
Despite evidence that antitumor immunity can be protective against renal cell carcinoma (RCC), few patients respond objectively to immunotherapy and the disease is fatal once metastases develop. We asked to what extent combinatorial immunotherapy wit
Externí odkaz:
https://doaj.org/article/4fe1df20141b475bafe5b1f1f928699e
Autor:
Van S. Tompkins, Alicia K. Olivier, Carol J. Holman, Xuefang Jing, Susan A. Walsh, Timothy R. Rosean, Casey Dehoedt, Kaylia Duncan, Guido Tricot, Siegfried Janz, Michael R. Acevedo, Fenghuang Zhan, Shelby D. Foor
Publikováno v:
Leukemia. 30:962-966
e66 transduced in vitro with a retroviral luciferase reporter gene. The B cells give rise to myeloma plasma cell tumors that recapitulate the primary bone marrow manifestation of the disease more accurately than anything we have seen before. The find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1958fe1b88cf4108d5363941d04498
https://doi.org/10.1038/leu.2015.197
https://doi.org/10.1038/leu.2015.197
Autor:
Timothy R. Rosean, Christiane Stuhlmann-Laeisz, Van S. Tompkins, Giovanna Tosato, Wolfram Klapper, Stefan Rose-John, Siegfried Janz, Jürgen Scheller, Jan Suthaus
Publikováno v:
Blood. 119:5173-5181
Human herpes virus 8 (HHV-8) or Kaposi sarcoma-associated herpes virus is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and plasma cell-type multicentric Castleman disease (MCD). HHV-8 encodes a viral homolog of human IL-6, called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d50e0000abcf8100fd86d34b92e7a39
https://doi.org/10.1182/blood-2011-09-377705
https://doi.org/10.1182/blood-2011-09-377705
Publikováno v:
The Journal of Immunology. 198:54.15-54.15
Systemic lupus erythematosus (SLE) is an autoimmune disease driven by the secretion of anti-nuclear antibodies (ANA) from a subset of terminally differentiated B cells, called plasma cells (PC). PC persist in the bone marrow for the lifetime of the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::208dec3c7f38e3e5232a5f3bd67c13ba
https://doi.org/10.4049/jimmunol.198.supp.54.15
https://doi.org/10.4049/jimmunol.198.supp.54.15
Autor:
Thomas J. Waldschmidt, Herbert C. Morse, Ramakrishna Sompallae, Siegfried Janz, Lyse A. Norian, Alicia K. Olivier, Van S. Tompkins, Timothy R. Rosean
Publikováno v:
Leukemia. 29(1)
The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395ed42ccb1b31ed239563b4c74d5807
https://pubmed.ncbi.nlm.nih.gov/25257990
https://pubmed.ncbi.nlm.nih.gov/25257990
Autor:
Alicia K. Olivier, Van S. Tompkins, Carol J. Holman, Guido Tricot, Siegfried Janz, Fenghuang Zhan, Timothy R. Rosean
Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579cf914fcee9942d3de6260da9c279d
https://europepmc.org/articles/PMC4209159/
https://europepmc.org/articles/PMC4209159/
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65599 (2013)
PLoS ONE
PLoS ONE
Tumor metastasis plays a major role in the morbidity and mortality of cancer patients. Among solid tumors that undergo metastasis, there is often a predilection to metastasize to a particular organ with, for example, prostate cancer preferentially me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4cdc85119e4740ecdb43a65945306b
http://europepmc.org/articles/PMC3679158?pdf=render
http://europepmc.org/articles/PMC3679158?pdf=render
Autor:
Herbert C. Morse, Jerold E. Rehg, Susan A. Walsh, Michael R. Acevedo, Sunderland Js, Van S. Tompkins, Ramakrishna Sompallae, Timothy R. Rosean, Siegfried Janz, Xuefang Jing, Seong-Su Han, Carol J. Holman, Alexander L. Kovalchuk, Herms S
Publikováno v:
Blood Cancer Journal. 6:e488-e488
Waldenström macroglobulinemia (WM) is a low-grade incurable immunoglobulin M+ (IgM+) lymphoplasmacytic lymphoma for which a genetically engineered mouse model of de novo tumor development is lacking. On the basis of evidence that the pro-inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::445d461586e35c9e775fe5cf659c9b6b
https://doi.org/10.1038/bcj.2016.95
https://doi.org/10.1038/bcj.2016.95