Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Timothy R Crother"'
Autor:
Ana Paula Lombardi Pereira, Emily Aubuchon, Debbie P. Moreira, Malcolm Lane, Thacyana T. Carvalho, Thassio R. R. Mesquita, Youngho Lee, Timothy R. Crother, Rebecca A. Porritt, Waldiceu A. Verri, Magali Noval Rivas, Moshe Arditi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundKawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of coronary artery aneurysms (CAA) in affected chil
Externí odkaz:
https://doaj.org/article/bab04e8fb821462888b2d774045c3cc8
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
While recent advances in diagnostics and therapeutics offer promising new approaches for Alzheimer's disease (AD) diagnosis and treatment, there is still an unmet need for an effective remedy, suggesting new avenues of research are required. Besides
Externí odkaz:
https://doaj.org/article/c059d6efb4fd4d5693b855c58589ebff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Cardiovascular diseases (CVDs) are one of the primary causes of mortality worldwide. An optimal mitochondrial function is central to supplying tissues with high energy demand, such as the cardiovascular system. In addition to producing ATP as a power
Externí odkaz:
https://doaj.org/article/0145f6c501324daab7f79ef8b864b855
Autor:
Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androg
Externí odkaz:
https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab16
Autor:
Stefanie Marek-Iannucci, Asli B. Ozdemir, Debbie Moreira, Angela C. Gomez, Malcolm Lane, Rebecca A. Porritt, Youngho Lee, Kenichi Shimada, Masanori Abe, Aleksandr Stotland, David Zemmour, Sarah Parker, Elsa Sanchez-Lopez, Jennifer Van Eyk, Roberta A. Gottlieb, Michael C. Fishbein, Michael Karin, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Murine and human data suggest that the NLRP3–IL-1β pathway is the main driver of KD pathophysiology. NLRP3 can be activated during defective autophagy/mitophagy.
Externí odkaz:
https://doaj.org/article/8c3c23459c15468788622df34392f6d5
Autor:
Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repa
Externí odkaz:
https://doaj.org/article/804a8420fafe4285aba0bf129953d581
Autor:
Shuang Chen, Timothy R. Crother
Publikováno v:
EBioMedicine, Vol 55, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/89522f48708b4525876fbf82eae054f9
Autor:
Nobuyuki Nosaka, Daisy Martinon, Debbie Moreira, Timothy R. Crother, Moshe Arditi, Kenichi Shimada
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Targeting inflammasome activation to modulate interleukin (IL)-1β is a promising treatment strategy against acute respiratory distress syndrome and ventilator-induced lung injury (VILI). Autophagy is a key regulator of inflammasome activation in mac
Externí odkaz:
https://doaj.org/article/10d86235375f408fb14024af3dfb5a99
Autor:
Karen A. Cavassani, Rebecca J. Meza, David M. Habiel, Jie‐Fu Chen, Alexander Montes, Manisha Tripathi, Gislâine A. Martins, Timothy R. Crother, Sungyong You, Cory M. Hogaboam, Neil Bhowmick, Edwin M. Posadas
Publikováno v:
Cancer Medicine, Vol 7, Iss 9, Pp 4639-4649 (2018)
Abstract Background Recruited myeloid cells are known to promote cancer initiation, malignant progression, metastasis, and resistance to therapy in the tumor niche. We tested the hypothesis that circulating blood monocytes from advanced prostate canc
Externí odkaz:
https://doaj.org/article/0e4c64c5e9094fe7a9f5f0034f5c5244
Autor:
Timothy R. Crother, Rebecca A. Porritt, Jargalsaikhan Dagvadorj, Gantsetseg Tumurkhuu, Anatoly V. Slepenkin, Ellena M. Peterson, Shuang Chen, Kenichi Shimada, Moshe Arditi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autophagy can either antagonize or promote intracellular bacterial growth, depending on the pathogen. Here, we investigated the role of autophagy during a pulmonary infection with the obligate intracellular pathogen, Chlamydia pneumoniae (CP). In mou
Externí odkaz:
https://doaj.org/article/1f7e389b850a42559f78451bd7be1600