Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Timothy R, Dafforn"'
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine e
Externí odkaz:
https://doaj.org/article/8359357ba2624784b5140879793cd87d
Autor:
Haydn A. Little, Aysha Ali, Jake G. Carter, Matthew R. Hicks, Timothy R. Dafforn, James H. R. Tucker
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
A plug-and-play sandwich assay platform for the aptamer-based detection of molecular targets using linear dichroism (LD) spectroscopy as a read-out method has been demonstrated. A 21-mer DNA strand comprising the plug-and-play linker was bioconjugate
Externí odkaz:
https://doaj.org/article/8ce6b2a36d594938aacb3d1fd3e01143
Autor:
Jake G. Carter, Rueben Pfukwa, Liam Riley, James H. R. Tucker, Alison Rodger, Timothy R. Dafforn, Bert Klumperman
Publikováno v:
ACS Omega, Vol 6, Iss 48, Pp 33231-33237 (2021)
Externí odkaz:
https://doaj.org/article/e6344d207db3410f81daf02f0e652c93
Autor:
Philip N. Jemmett, David C. Milan, Richard J. Nichols, Thomas Howitt, Alexandra L. Martin, Thomas Arnold, Jonathan L. Rawle, Christopher L. Nicklin, Timothy R. Dafforn, Liam R. Cox, Sarah L. Horswell
Publikováno v:
Langmuir. 38:14290-14301
Sphingolipids are an important class of lipids found in mammalian cell membranes with important structural and signaling roles. They differ from another major group of lipids, the glycerophospholipids, in the connection of their hydrocarbon chains to
Autor:
Huanyu Z. Li, Ashley C.W. Pike, Gamma Chi, Jesper S. Hansen, Sarah G. Lee, Karin E.J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0b3c1551d3725c4f410b48f6a6e46
https://doi.org/10.1101/2023.05.17.541173
https://doi.org/10.1101/2023.05.17.541173
Publikováno v:
Biochemical Journal. 479:145-159
ATP-binding cassette (ABC) proteins play important roles in cells as importers and exporters but as membrane proteins they are subject to well-known challenges of isolating pure and stable samples for study. One solution to this problem is to use sty
Autor:
Seyed R. Tabaei, Paula M. Mendes, James H. R. Tucker, Setareh Vafaei, Timothy R. Dafforn, Louise Male, Francia Allabush
Publikováno v:
ACS Nano
The dynamic nature of micellar nanostructures is employed to form a self-assembled Förster resonance energy transfer (FRET) nanoplatform for enhanced sensing of DNA. The platform consists of lipid oligonucleotide FRET probes incorporated into micell
Autor:
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J Hill, Cristina Matas de las Heras, Ana Teodosio, Andrea S Lavado, Timothy R Dafforn, Dimitris K Grammatopoulos, John Gordon, Catherine A Brady, Lawrence S Young, Nicholas M Barnes, Zania Stamataki, Omar S Qureshi
The engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells and accordingly blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine-elicited serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49fc2eadd7fcf70f0b9f3092b3d38880
https://doi.org/10.1101/2022.06.24.496409
https://doi.org/10.1101/2022.06.24.496409
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
M13 bacteriophage is a well-established versatile nano-building block, which can be employed to produce novel self-assembled functional materials and devices. Sufficient production and scalability of the M13, often require a large quantity of the vir