Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Timothy Perera"'
Autor:
Marie Fernandes, Brynna Hoggard, Philippe Jamme, Sonia Paget, Marie‐José Truong, Valérie Grégoire, Audrey Vinchent, Clotilde Descarpentries, Angela Morabito, Justas Stanislovas, Enoir Farage, Jean‐Pascal Meneboo, Shéhérazade Sebda, Katia Bouchekioua‐Bouzaghou, Marie Nollet, Sarah Humez, Timothy Perera, Paul Fromme, Luca Grumolato, Martin Figeac, Marie‐Christine Copin, David Tulasne, Alexis B. Cortot, Stéphanie Kermorgant, Zoulika Kherrouche
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2257-2274 (2023)
Exon skipping mutations of the MET receptor tyrosine kinase (METex14), increasingly reported in cancers, occur in 3–4% of non–small‐cell lung cancer (NSCLC). Only 50% of patients have a beneficial response to treatment with MET‐tyrosine kinas
Externí odkaz:
https://doaj.org/article/272f451e35f5414da2913aa27cf75f12
Autor:
Jonas Steenbrugge, Julie Bellemans, Niels Vander Elst, Kristel Demeyere, Josephine De Vliegher, Timothy Perera, Olivier De Wever, Wim Van Den Broeck, Ward De Spiegelaere, Niek N. Sanders, Evelyne Meyer
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Aggressive triple-negative breast cancer (TNBC) is classically treated with chemotherapy. Besides direct tumor cell killing, some chemotherapeutics such as cisplatin provide additional disease reduction through stimulation of anti-tumor immunity. The
Externí odkaz:
https://doaj.org/article/43e3a4da86074245a2ec0241aef761e8
Autor:
Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract c-MET is considered a driver of cancer progression, impacting tumor growth and tumor-supporting stroma. Here, we investigated the therapeutic efficacy of OMO-1, a potent and selective c-MET inhibitor, in an immunocompetent intraductal mouse
Externí odkaz:
https://doaj.org/article/b9aac903f53b496da8763625e4385c99
Autor:
Concetta D’Ambrosio, Jessica Erriquez, Sonia Capellero, Simona Cignetto, Maria Alvaro, Eric Ciamporcero, Maria Flavia Di Renzo, Timothy Perera, Giorgio Valabrega, Martina Olivero
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5770 (2022)
The MET oncogene encodes a tyrosine kinase (TK) receptor. Its activation protects cells from death but also stimulates DNA damage response by triggering excess replicative stress. Transcriptomic classification of cancer cell lines based on MET expres
Externí odkaz:
https://doaj.org/article/4982cc1d96644e238a429c9718b0cb69
Autor:
Francesca De Bacco, Antonio D'Ambrosio, Elena Casanova, Francesca Orzan, Roberta Neggia, Raffaella Albano, Federica Verginelli, Manuela Cominelli, Pietro L Poliani, Paolo Luraghi, Gigliola Reato, Serena Pellegatta, Gaetano Finocchiaro, Timothy Perera, Elisabetta Garibaldi, Pietro Gabriele, Paolo M Comoglio, Carla Boccaccio
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 5, Pp 550-568 (2016)
Abstract Glioblastoma (GBM) contains stem‐like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence. It is known that GSC radioresistance relies on efficient activ
Externí odkaz:
https://doaj.org/article/e3a220eeaa804cb09dc87829df92d2bd
Autor:
Salvatore Siena, Silvia Giordano, Federica Di Nicolantonio, Livio Trusolino, Paolo Comoglio, Victor E. Velculescu, Mark Sausen, Luis A. Diaz, Marcello Gambacorta, Alessio Amatu, Giorgio Corti, Silvio Veronese, Timothy Perera, Carlo Zanon, Calogero Lauricella, Francesco Galimi, Giorgia Migliardi, Maria Apicella, Davide Zecchin, Andrea Cassingena, Elisa Scala, Andrea Sartore-Bianchi, Giulia Siravegna, Emanuele Valtorta, Sebastijan Hobor, Andrea Bertotti, Simona Corso, Alberto Bardelli
Supplementary Figure S4 - PDF file 19K, Ectopic expression of MET in cetuximab sensitive DIFI and LIM1215 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e3c15de8cb9ba777bef634b043bc13
https://doi.org/10.1158/2159-8290.22529322.v1
https://doi.org/10.1158/2159-8290.22529322.v1
Autor:
Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta
XLSX file 75K, This is an excel file containing 9 sheets, one for each of the 9 supplementary tables (S1 to S9) mentioned in the main text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f2683ba8a868adc9f8a76d6605235a
https://doi.org/10.1158/2159-8290.22530114.v1
https://doi.org/10.1158/2159-8290.22530114.v1
Autor:
Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta
PDF file 234K, This is a file containing the list of supplementary tables, the list of supplementary figures, as well as the 7 supplementary figures (S1 to S7) and their correspondent legends, mentioned in the main text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f05e4cc23df9c591b388d0865f7bb
https://doi.org/10.1158/2159-8290.22530117
https://doi.org/10.1158/2159-8290.22530117
Autor:
Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta
We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional fusion-positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4ae6f70c75968b34b2f3d7faa842ab
https://doi.org/10.1158/2159-8290.c.6546108
https://doi.org/10.1158/2159-8290.c.6546108
Autor:
Andrea Bertotti, Livio Trusolino, Paolo M. Comoglio, Maria Flavia Di Renzo, Enzo Medico, Timothy Perera, Lorenzo Capussotti, Mauro Salizzoni, Mauro Risio, Bruno Torchio, Ezio David, Alberto Pisacane, Francesca Maione, Federica Gonella, Gianluca Paraluppi, Dimitrios Siatis, Paolo Massucco, Andrea Muratore, Dario Ribero, Stefania Gastaldi, Davide Corà, Claudio Isella, Francesco Sassi, Davide Torti, Francesco Galimi
Purpose: We determined the gene copy numbers for MET, for its transcriptional activator MACC1 and for its ligand hepatocyte growth factor (HGF) in liver metastases from colorectal carcinoma (mCRC). We correlated copy numbers with mRNA levels and expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae8fe43d8411ecb5e2655e5a49b5cc4
https://doi.org/10.1158/1078-0432.c.6518392.v1
https://doi.org/10.1158/1078-0432.c.6518392.v1