Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Timothy Paradis"'
Publikováno v:
Immunotherapy. 14:1467-1480
Aims: To determine whether antigen-independent targeting of the TOP1 inhibitor exatecan to tumor with a pH-sensitive peptide (CBX-12) produces superior synergy with immunotherapy compared with unconjugated exatecan. Materials & methods: In vitro and
Publikováno v:
Immunotherapy.
Although combinations of chemotherapy and immunotherapy have shown great promise for cancer treatment, they have also demonstrated significant safety concerns that require dose reductions. Targeting chemotherapy to the tumor can avoid these safety is
Autor:
Sophia Gayle, Robert Aiello, Nalin Leelatian, Jason M Beckta, Jane Bechtold, Patricia Bourassa, Johanna Csengery, Robert J Maguire, Dan Marshall, Ranjini K Sundaram, Jinny Van Doorn, Kelli Jones, Hunter Moore, Lori Lopresti-Morrow, Timothy Paradis, Laurie Tylaska, Qing Zhang, Hannah Visca, Yana K Reshetnyak, Oleg A Andreev, Donald M Engelman, Peter M Glazer, Ranjit S Bindra, Vishwas M Paralkar
Publikováno v:
NAR Cancer. 3
Autor:
Sophia Gayle, Robert Aiello, Jane Bechtold, Patricia Bourassa, Johanna Csengery, Connor Hagen, Katia Howard, Kelli Jones, Lori Lopresti-Morrow, Robert Maguire, Timothy Paradis, Theresa Pasqualini, Joseph Tweed, Laurie Tylaska, Qing Zhang, Vishwas Paralkar
Publikováno v:
Cancer Research. 82:1764-1764
Auristatins such as monomethyl auristatin E (MMAE) are a class of high potency microtubule targeting compounds that have an extremely narrow therapeutic window. Targeting potent auristatins to the tumor is the only feasible method of unlocking the cl
Autor:
Sophia Gayle, Juan Vasquez, Timothy Paradis, Kelli Jones, Ranjini Sundaram, Jinny van Doorn, Viswanathan Muthusamy, Ranjit S. Bindra, Robert J. Aiello, Vishwas Paralkar
Publikováno v:
Molecular Cancer Therapeutics. 20:P258-P258
Immune checkpoint blockade (ICB) in combination with chemotherapy is standard of care for several solid tumors. However, potent chemotherapies such as topoisomerase inhibitors can result in severe dose-limiting toxicities requiring dose reduction, li
Autor:
Hannah Stenger, Elena Carbone, Catherine Ratte, Elaine Puleo, Kathy Wicks, Jesse Mushenko, Jerusha Nelson Peterman, Timothy Paradis, Jessica Collins
Publikováno v:
The FASEB Journal. 29
In 2012, Springfield, MA received CDC funding to promote healthy behaviors and health equity via expansion of the LWS initiative. Strategies include: (1) opening a full-line grocery store, (2) incr...