Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Timothy P. Smyth"'
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/31424864c41e4b9d8cd3a00bc1c4c205
Autor:
Mingxi Yang, Timothy J. Smyth, Vassilis Kitidis, Ian J. Brown, Charel Wohl, Margaret J. Yelland, Thomas G. Bell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The flux of CO2 between the atmosphere and the ocean is often estimated as the air–sea gas concentration difference multiplied by the gas transfer velocity (K 660). The first order driver for K 660 over the ocean is wind through its influe
Externí odkaz:
https://doaj.org/article/8876030efbf54167bae0d984071ff7bf
Autor:
Janelle M. Veazey, Sophia I Eliseeva, Sara E. Hillman, Kristie Stiles, Timothy R. Smyth, Charlotte E. Morrissey, Erika J. Tillotson, Dave J. Topham, Timothy J. Chapman, Steve N. Georas
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
RationaleProtein kinase D (PKD) is a serine/threonine kinase family that is involved in a wide array of signaling pathways. Although PKD has been implicated in immune responses, relatively little is known about the function of PKD in the lung or duri
Externí odkaz:
https://doaj.org/article/e1ddf0704ace48ea99914131e4c689d6
Autor:
Louise Elisabeth Cornwell, Elaine S. Fileman, John T. Bruun, Andrew Garwood Hirst, Glen Adam Tarran, Helen S. Findlay, Ceri Lewis, Timothy James Smyth, A. J. McEvoy, A. Atkinson
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
There has been an overall decline in copepod populations across the North Atlantic over the past few decades. Reasons for these declines are unclear, and several major species, including the cyclopoid copepod Oithona similis, have maintained stable p
Externí odkaz:
https://doaj.org/article/9b776ec7cbcf413dafc6a238f4fe514e
Autor:
Janelle M Veazey, Timothy J Chapman, Timothy R Smyth, Sara E Hillman, Sophia I Eliseeva, Steve N Georas
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216056 (2019)
The airway epithelial barrier is critical for preventing pathogen invasion and translocation of inhaled particles into the lung. Epithelial cells also serve an important sentinel role after infection and release various pro-inflammatory mediators tha
Externí odkaz:
https://doaj.org/article/f45762c71b8447ed9d938c760a934fc3
Publikováno v:
Journal of Heterocyclic Chemistry. 48:286-294
A modular synthesis of selectively-substituted pyrrolo[2,1-b]thiazoles (Δ6 isomeric form) has been implemented, involving a distinctive bicyclization reaction of a mucobromic acid derivative followed by a Suzuki-Miyaura coupling. A novel process of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728ac5dabd8e00340cdfe1322b9fdcf5
https://doi.org/10.1002/jhet.550
https://doi.org/10.1002/jhet.550
Autor:
Timothy P. Smyth, Jonathan W. Grant
Publikováno v:
The Journal of Organic Chemistry. 69:7965-7970
In previous work we have shown that a cephalosporin structure bearing an S-aminosulfenimine at the 7-position behaved as a beta-lactamase-dependent dual-release prodrug. Scission of the beta-lactam ring of such a structure led to the rapid loss of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bf47077aedb88d849e6750f4ce92d8
https://doi.org/10.1021/jo048970i
https://doi.org/10.1021/jo048970i
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:991-998
An analysis of the X-ray structure of cilastatin bound to membrane dipeptidase, together with docking studies, is presented here to reveal how a simple amide may act as a high-affinity, reversible, amidase inhibitor. Cilastatin binds as a normal subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede1dbecae21ac79a34b7691d2b9e22
https://doi.org/10.1016/s0968-0896(02)00519-9
https://doi.org/10.1016/s0968-0896(02)00519-9
Autor:
Timothy P. Smyth, Anthony D. Gray
Publikováno v:
The Journal of Organic Chemistry. 66:7113-7117
The preparation of substituted-2-tetralones by direct reaction of a 1-alkene with a substituted phenylacetic acid in a reaction system of trifluoroacetic anhydride (TFAA) and phosphoric acid is described. This single-stage process involves in situ fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f91df0f6495775b09a80a75f5c7697c
https://doi.org/10.1021/jo0158074
https://doi.org/10.1021/jo0158074
Publikováno v:
Tetrahedron. 56:5699-5707
Penicillins and cephalosporins bearing an S-aminosulfenimine side chain at the 6- and 7-positions, respectively, are prototypic examples of novel classes of β-lactamase-dependent prodrugs wherein enzyme-catalyzed cleavage of the β-lactam ring trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c85fc8d8f6bd4c35b854245c9c2ebcb8
https://doi.org/10.1016/s0040-4020(00)00419-1
https://doi.org/10.1016/s0040-4020(00)00419-1