Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Timothy P. Shiau"'
Autor:
Mohanram Sivaraja, Nicola Pozzi, Matthew Rienzo, Kenneth Lin, Timothy P Shiau, Daniel M Clemens, Lev Igoudin, Piotr Zalicki, Stephanie S Chang, M Angels Estiarte, Kevin M Short, David C Williams, Anirban Datta, Enrico Di Cera, David B Kita
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201377 (2018)
INTRODUCTION:In recent years, the traditional treatments for thrombotic diseases, heparin and warfarin, are increasingly being replaced by novel oral anticoagulants offering convenient dosing regimens, more predictable anticoagulant responses, and le
Externí odkaz:
https://doaj.org/article/f610424ff315488398aaec24e248f870
Autor:
Ashley Houchin, Donogh J R O'Mahony, Chris Celeri, Ramin Najafi, Eddy Low, Timothy P. Shiau, Rakesh K. Jain, Ping Xu, Bum Tae Kim, Charles Francavilla, Mark B. Anderson, Meghan Zuck, Nichole J Alvarez, Eric Douglas Turtle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3682-3685
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e623ed81938624b45311b013b638f0a8
https://doi.org/10.1016/j.bmcl.2011.04.084
https://doi.org/10.1016/j.bmcl.2011.04.084
Autor:
Kevin Michael Short, Georg Neckermann, Mohan Sivaraja, Anne Wong, Elaine To, Makena Ewald, Timothy P. Shiau, Sivan Sizikov, Subhadra Dash, David C. Williams, Anirban Datta, Madhuri Chattopadhyay, Nilantha Sudath Sirisoma, Stephanie W. Chang, Tamari Kirtadze, Angels Estiarte, David Ben Kita
Publikováno v:
Cancer Research. 78:4851-4851
We have developed a class of small-molecule cytotoxic compounds that are highly potent in an in vitro tubulin polymerization assay. Preclinical studies show that these drug candidates are potent against a range of cancer cell lines and may be well su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9e3bca64401ebfd8dbf581207464fe
https://doi.org/10.1158/1538-7445.am2018-4851
https://doi.org/10.1158/1538-7445.am2018-4851
Autor:
Dmitri Debabov, Ashley Houchin, Chris Celeri, Eddy Low, Rakesh K. Jain, Bum Tae Kim, Ron Najafi, Satheesh K. Nair, Charles Francavilla, Timothy P. Shiau, Nichole J Alvarez, Ping Xu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2731-2734
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quatern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc5e23717325e604cf5fef60704fb16
https://doi.org/10.1016/j.bmcl.2009.03.120
https://doi.org/10.1016/j.bmcl.2009.03.120
Publikováno v:
Biochemistry. 44:7704-7712
The fluorogenic reagent 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABDF) attenuates the functional activity of the protein tyrosine phosphatase PTP1B by reacting selectively with a single cysteine residue, leaving other cysteines in the protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbd70060c41af4cce22abead3e8d31d
https://doi.org/10.1021/bi047417s
https://doi.org/10.1021/bi047417s
Publikováno v:
Organic Letters. 8:5697-5699
Isothiazolidinones are a rare but potentially important chemical moiety in biochemistry. We report the identification of several thiol, phosphinate, and carbon nucleophiles that form covalent adducts by addition to the sulfenamide sulfur. This reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c39708b823351defa34465ab3380fb
https://doi.org/10.1021/ol062077j
https://doi.org/10.1021/ol062077j
Autor:
Louisa D'Lima, Timothy P. Shiau, Ramin Najafi, Mark L Anderson, Meghan Zuck, Rakesh K. Jain, Andreas Jekle, Dmitri Debabov, Eddy Low, Charles Francavilla, Eric Douglas Turtle, Bum Tae Kim, Lisa Friedman, Nichole J Alvarez, Donogh J R O'Mahony
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(20)
The discovery and development of antimicrobial agents that do not give rise to resistance remains an ongoing challenge. Our efforts in this regard continue to reveal new potential therapeutic agents with differing physicochemical properties while ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69fff1f82a257c236caf088a6e47042
https://pubmed.ncbi.nlm.nih.gov/23999044
https://pubmed.ncbi.nlm.nih.gov/23999044
Autor:
Mark L Anderson, Dmitri Debabov, Andreas Jekle, Lu Wang, Christian Eitzinger, Timothy P. Shiau, Jungjoo Yoon, Suriani Abdul Rani, Meghan Zuck, Markus Nagl, Ramin Najafi, Charles Francavilla
Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d335d3eb7281b24b6df3849d9b3c6c2a
https://europepmc.org/articles/PMC3553688/
https://europepmc.org/articles/PMC3553688/
Autor:
Ramin Najafi, Timothy P. Shiau, Mark B. Anderson, Meghan Zuck, Lisa C Friedman, Eddy Low, Eric Douglas Turtle, Nichole J Alvarez, Donogh J R O'Mahony, Rakesh K. Jain, Charles Francavilla
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X=H) as antibacterial and antifungal agents. The key findings were that the activity and apparent in vitro cytotoxicity c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4ec97203a656fe7860b4c65cf3c53e
https://pubmed.ncbi.nlm.nih.gov/21470861
https://pubmed.ncbi.nlm.nih.gov/21470861
Autor:
Meghan Zuck, Bum Tae Kim, Eric Douglas Turtle, Nichole J Alvarez, Chris Celeri, Rakesh K. Jain, Donogh J R O'Mahony, Mark B. Anderson, Ramin Najafi, Ping Xu, Charles Francavilla, Lisa C Friedman, Timothy P. Shiau, Francis S Ruado, Eddy Low, Louisa D'Lima
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b31f4d6f36d833323d9c064b78d3b
https://pubmed.ncbi.nlm.nih.gov/21459574
https://pubmed.ncbi.nlm.nih.gov/21459574