Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Timothy P. O'Sullivan"'
Publikováno v:
Molecules, Vol 28, Iss 11, p 4317 (2023)
A methodology for the asymmetric peroxidation of γ,δ-unsaturated β-keto esters is presented. Using a cinchona-derived organocatalyst, the target δ-peroxy-β-keto esters were obtained in high enantiomeric ratios of up to 95:5. Additionally, these
Externí odkaz:
https://doaj.org/article/5ad5c9fea74c422cb59ef005e09744a6
Autor:
Timothy P. O’Sullivan
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 16 (2022)
Quorum sensing is a bacterial mechanism that is essential in the pathogenesis of many infections, such as P. aeruginosa. These infections are strongly influenced by specific quorum sensing molecules, such as Autoinducer-2 (AI-2). AI-2 binds to quorum
Externí odkaz:
https://doaj.org/article/7034a1c0b9c24ecf9422ca24d56d4a28
Autor:
Shi-qi An, Julie Murtagh, Kate B. Twomey, Manoj K. Gupta, Timothy P. O’Sullivan, Rebecca Ingram, Miguel A. Valvano, Ji-liang Tang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Biofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al. synthesize DSF analogues that modulate PA1396 act
Externí odkaz:
https://doaj.org/article/551913c042084dbbbcb6ec863181c625
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 801-810 (2019)
An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium tert-butoxide and DMF, to achieve
Externí odkaz:
https://doaj.org/article/c2aa1d66016741ac8a84ec48674a15b9
Autor:
David J. Jones, Uday B. Rao Khandavilli, Eileen M. O’Leary, Simon E. Lawrence, Timothy P. O’Sullivan
Publikováno v:
SynOpen, Vol 02, Iss 04, Pp 0263-0267 (2018)
Abstract Efficient S-acylation of thiourea using a variety of acid chlorides is reported. Structurally diverse aryl and alkyl substrates are compatible with this methodology. Confirmation that acylation occurs exclusively on the sulfur atom of thio
Externí odkaz:
https://doaj.org/article/d932d10371694d54a8727ff463d5bee8
Autor:
Rui Li, Cristian Camilo Galindo, Dominique Davidson, Huaijian Guo, Ming-Chao Zhong, Jin Qian, Bin Li, Zsolt Ruzsics, Colleen M. Lau, Timothy E. O'Sullivan, Silvia M. Vidal, Joseph C. Sun, André Veillette
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113800- (2024)
Summary: Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be “adaptive” or “memory” NK cells. Here, we find that signaling lymp
Externí odkaz:
https://doaj.org/article/adb6c93e5f704d00b240fb56f26c9322
Autor:
Jorge Pinheiro, Thérèse Lyons, Vanessa Las Heras, Miguel Villoria Recio, Cormac GM Gahan, Timothy P O'Sullivan
Publikováno v:
Future Medicinal Chemistry. 15:317-332
Aim: Vibrio harveyi is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). V. harveyi uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::490573ab7dbc029b1c33ae662eee6abc
https://doi.org/10.4155/fmc-2022-0235
https://doi.org/10.4155/fmc-2022-0235
Publikováno v:
Future medicinal chemistry. 14(24)
Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78764093526d7f6796ba436153f500d8
https://pubmed.ncbi.nlm.nih.gov/36449363
https://pubmed.ncbi.nlm.nih.gov/36449363
Autor:
Andromeda-Celeste Gómez, Thérèse Lyons, Uwe Mamat, Daniel Yero, Marc Bravo, Xavier Daura, Osama Elshafee, Sascha Brunke, Cormac G.M. Gahan, Michelle O'Driscoll, Isidre Gibert, Timothy P. O'Sullivan
Publikováno v:
European journal of medicinal chemistry. 242
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07eae8be1b262113cd58b16cfa481ce6
https://pubmed.ncbi.nlm.nih.gov/36037789
https://pubmed.ncbi.nlm.nih.gov/36037789
Publikováno v:
Future Medicinal Chemistry. 12:1925-1943
Since their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which bacteria co-ordinate their mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb9bb561242588def6144cf4cbe31fc
https://doi.org/10.4155/fmc-2020-0244
https://doi.org/10.4155/fmc-2020-0244