Zobrazeno 1 - 4
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pro vyhledávání: '"Timothy P. Mui"'
Publikováno v:
Nucleic Acids Research
A covalently branched nucleic acid can be synthesized by joining the 2'-hydroxyl of the branch-site ribonucleotide of a DNA or RNA strand to the activated 5'-phosphorus of a separate DNA or RNA strand. We have previously used deoxyribozymes to synthe
Autor:
Timothy P. Mui, Scott K. Silverman
Publikováno v:
Organic Letters. 10:4417-4420
We report a deoxyribozyme (DNA enzyme) that catalyzes the convergent and general synthesis of branched DNA. The 15HA9 deoxyribozyme mediates nucleophilic attack of the 2'-hydroxyl group of a ribonucleotide embedded within one DNA substrate into a 5'-
Damaged bases in DNA are known to lead to errors in replication and transcription, compromising the integrity of the genome. We have proposed a model where repair proteins containing redox-active [4Fe-4S] clusters utilize DNA charge transport (CT) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b330aef05f0d18ecf69ce9e1d2099fae
https://resolver.caltech.edu/CaltechAUTHORS:20120228-100512207
https://resolver.caltech.edu/CaltechAUTHORS:20120228-100512207
Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription. The DNA-mediated redox signal resembles that of base excision repair p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc023545a20be71de15e0e95a25b0de
https://europepmc.org/articles/PMC3234108/
https://europepmc.org/articles/PMC3234108/