Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension

Autor: Oscar van derHave, Timothy J. Mead, Christian Westöö, Niccolò Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren‐Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran‐Lundmark

Publikováno v: Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)

Abstract Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrec

Externí odkaz: https://doaj.org/article/9ec517eecbfa42948ac1c94d671fac5f

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Autor: Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte

Publikováno v: eLife, Vol 11 (2022)

The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur

Externí odkaz: https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Autor: Bram P. Prins, Timothy J. Mead, Jennifer A. Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A. Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T. Klena, George C. Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M. Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V. Smith, Niek Verweij, Helen R. Warren, Stefan Weiss, Alvaro Alonso, David O. Arnar, Michiel L. Bots, Rudolf A. de Boer, Anna F. Dominiczak, Mark Eijgelsheim, Patrick T. Ellinor, Xiuqing Guo, Stephan B. Felix, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Paul L. Huang, J. W. Jukema, Mika Kähönen, Jan A. Kors, Pier D. Lambiase, Lenore J. Launer, Man Li, Allan Linneberg, Christopher P. Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M. Psaty, Olli T. Raitakari, Kenneth M. Rice, Jerome I. Rotter, Moritz F. Sinner, Elsayed Z. Soliman, Tim D. Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G. Wilson, Zhijun Xie, Folkert W. Asselbergs, Marcus Dörr, Cornelia M. van Duijn, Paolo Gasparini, Daniel F. Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K. Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J. Lin, Steven A. Lubitz, Dennis O. Mook-Kanamori, Francesco J. Conti, Christopher H. Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J. Samani, Gianfranco Sinagra, Blair H. Smith, Hilma Holm, Bruno H. Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S. Apte, Pim van der Harst, Kari Stefansson, Patricia B. Munroe, Dan E. Arking, Cecilia W. Lo, Yalda Jamshidi

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)

Abstract Background Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the varia

Externí odkaz: https://doaj.org/article/90c79bdbde864108a63e5a86f193c9b6

The Influence of iPads on Course Performance and Student Perceptions of Learning in Human Anatomy

Autor: Timothy P. Mead, Claire Larson, Lesley M. Scibora

Publikováno v: Journal of Teaching and Learning with Technology. 7:108-124

The influence of iPad compared to computer-based active and collaborative learning activities on academic performance, along with student attitudes toward technology, engagement, and perceived learning were examined between two one-semester undergrad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8af922eb35aaaa86ae50b39992ac352
https://doi.org/10.14434/jotlt.v7i1.23973

The Effect of Exercise Intensity on Respiratory System Recovery and Post Exercise Pulmonary Function

Autor: Dennis J. Guillot, Arnold G. Nelson, Timothy P. Mead

Publikováno v: Medicine & Science in Sports & Exercise. 46:523-524

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74b9a6fccfcea631f53220d23ed18534
https://doi.org/10.1249/01.mss.0000495037.02091.aa