Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Timothy P. Kuka"'
Autor:
Caitlin B. Conboy, Germán L. Vélez‐Reyes, Barbara R. Tschida, Hsiangyu Hu, Gabriel Kaufmann, Nicholas Koes, Bryant Keller, Clara Alsinet, Helena Cornellà, Roser Pinyol, Juan E. Abrahante, Nuri A. Temiz, Michael A. Linden, Khalid Amin, Timothy P. Kuka, Vincent W. Keng, Josep M. Llovet, Timothy K. Starr, David A. Largaespada
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Externí odkaz:
https://doaj.org/article/0eab1ccaa58a47a08d90c0ba26613dba
Autor:
Jeffrey C. To, Amy P. Chiu, Barbara R. Tschida, Lilian H. Lo, Cynthia H. Chiu, Xiao-Xiao Li, Timothy P. Kuka, Michael A. Linden, Khalid Amin, Wing-Cheung Chan, Jason B. Bell, Branden S. Moriarity, David A. Largaespada, Vincent W. Keng
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100223- (2021)
Background & Aims: Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be a transcriptional repressor of the alpha-foetoprotein (Afp) gene in adult
Externí odkaz:
https://doaj.org/article/58dd8d290ff94e908089e3e2954c131c
Publikováno v:
Veterinary and Animal Science, Vol 21, Iss , Pp 100311- (2023)
Pharmacological and nutritional benefits of plant leaf extracts can be harnessed to address the problem of poor chick quality, performance and high mortality, which affect both hatchery and farm managers. This study sought to evaluate the in ovo effe
Externí odkaz:
https://doaj.org/article/913eb97d0dbe49f584dc3b9ec6fefccc
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Oncoprints showing steatosis-associated CIS gene amplifications, deep deletions, and mutations occurring in at least 5% of all(S5), steatosis-associated(S6), and alcohol-associated(S7) TCGA HCC cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454cd20e521cb04dc3547458aa1f7623
https://doi.org/10.1158/0008-5472.22415118
https://doi.org/10.1158/0008-5472.22415118
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4748c8642abdcd640f9066eead0b02
https://doi.org/10.1158/0008-5472.22415115
https://doi.org/10.1158/0008-5472.22415115
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b0044086c645f22a82bc79a8e64022
https://doi.org/10.1158/0008-5472.22415124
https://doi.org/10.1158/0008-5472.22415124
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Tables of mice(S7); CIS genes(S8); insertions(S9); human HCC CIS gene alterations(S10); steatosis-enriched CIS(S11); pathways altered in HCC(S12-18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c32a0e1af41d542b190be3d5477fe
https://doi.org/10.1158/0008-5472.22415112
https://doi.org/10.1158/0008-5472.22415112
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Supplementary Figure S1 shows FOXA1 and FOXA2 repression in steatotic mouse livers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14336f0f09fe9204fac85841f2a6ca4
https://doi.org/10.1158/0008-5472.22415127
https://doi.org/10.1158/0008-5472.22415127
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349548c9e97257a61c9487d5e590f052
https://doi.org/10.1158/0008-5472.c.6509181.v1
https://doi.org/10.1158/0008-5472.c.6509181.v1
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Transposon insertion profiles from animals with tumors sharing 0-2(S2), 3(S3), or >3(S4) insertions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19916e39b7494c746182ba412ebd4591
https://doi.org/10.1158/0008-5472.22415121
https://doi.org/10.1158/0008-5472.22415121