Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy P. Burkholder"'
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
The concentrations of LSN3154567 in the dog plasma samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e6822518f21d94bca7c1d9980cb9dc
https://doi.org/10.1158/1535-7163.22510030.v1
https://doi.org/10.1158/1535-7163.22510030.v1
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee608d35f9d18aa0d631046f9435f6
https://doi.org/10.1158/1535-7163.c.6539479
https://doi.org/10.1158/1535-7163.c.6539479
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Table S1: anti-proliferative activity of LSN3154567 against different cancer cell lines; Table S2: effects of NAM on the anti-proliferative activity of LSN3154567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f70612a84c12c12c5e1209c6248e3b6
https://doi.org/10.1158/1535-7163.22510024
https://doi.org/10.1158/1535-7163.22510024
Autor:
Bo, Tan, Debra A, Young, Zhao-Hai, Lu, Tao, Wang, Timothy I, Meier, Robert L, Shepard, Kenneth, Roth, Yan, Zhai, Karen, Huss, Ming-Shang, Kuo, James, Gillig, Saravanan, Parthasarathy, Timothy P, Burkholder, Michele C, Smith, Sandaruwan, Geeganage, Genshi, Zhao
Publikováno v:
The Journal of biological chemistry. 288(5)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for cellular metabolism, energy production, and DNA repair. NAMPT has been extensively studied because of its critic
Autor:
Volker, Wacheck, Michael, Lahn, Gemma, Dickinson, Wolfgang, Füreder, Renata, Meyer, Susanne, Herndlhofer, Thorsten, Füreder, Georg, Dorfner, Sada, Pillay, Valérie, André, Timothy P, Burkholder, Jacqueline K, Akunda, Leann, Flye-Blakemore, Dirk, Van Bockstaele, Richard F, Schlenk, Wolfgang R, Sperr, Peter, Valent
Publikováno v:
Cancer Management and Research
Background: Acute myeloid leukemia (AML) is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2
Autor:
Timothy P. Burkholder, Joshua R. Clayton, Mark E. Rempala, James R. Henry, John M. Knobeloch, David Mendel, Johnathan A. McLean, Yan Hao, David A. Barda, Eileen L. Considine, Mark T. Uhlik, Yuefeng Chen, Liandong Ma, Laura J. Bloem, Jacqueline K. Akunda, Denis J. McCann, Manuel Sanchez-Felix, David K. Clawson, Michael M. Lahn, James J. Starling
Publikováno v:
Investigational New Drugs. 30:1270-1271
Autor:
David Mitchell, Kevin P. Cole, Patrick M. Pollock, David M. Coppert, Timothy P. Burkholder, Joshua R. Clayton
Publikováno v:
Organic Process Research & Development; Jan2012, Vol. 16 Issue 1, p70-81, 12p