Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Timothy P. Atkins"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Common marmosets (Callithrix jacchus) were shown to be susceptible to inhalational infection with Coxiella burnetii, in a dose-dependent manner, producing a disease similar to human Q fever, characterized by a resolving febrile response. Illness was
Externí odkaz:
https://doaj.org/article/ec1b4daf8c1f4dae90c877e2035760ff
Autor:
Nicola J. Senior, Kalesh Sasidharan, Richard J. Saint, Andrew E. Scott, Mitali Sarkar-Tyson, Philip M. Ireland, Helen L Bullifent, Z. Rong Yang, Karen Moore, Petra C. F. Oyston, Timothy P. Atkins, Helen S. Atkins, Orkun S. Soyer, Richard W. Titball
Publikováno v:
BMC Microbiology, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background The World Health Organization has categorized plague as a re-emerging disease and the potential for Yersinia pestis to also be used as a bioweapon makes the identification of new drug targets against this pathogen a priority. Envi
Externí odkaz:
https://doaj.org/article/1ac8f1a3fcab47d2ad8d2ad511b68c40
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Historically, disease progression in animal models of Q fever has been carried out using PCR to monitor the presence of Coxiella burnetii DNA in the host. However, the colonization and dissemination of other bacterial infections in animal models are
Externí odkaz:
https://doaj.org/article/63057ebfe1f44e60b7abf7ac7c0f1df0
Autor:
Laura E. Marshall, Michelle Nelson, Carwyn H. Davies, Adam O. Whelan, Dominic C. Jenner, Madeleine G. Moule, Carmen Denman, Jon Cuccui, Timothy P. Atkins, Brendan W. Wren, Joann L. Prior
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
There is a requirement for an efficacious vaccine to protect people against infection from Francisella tularensis, the etiological agent of tularemia. The lipopolysaccharide (LPS) of F. tularensis is suboptimally protective against a parenteral letha
Externí odkaz:
https://doaj.org/article/2bc623d9492c4a739837f0fe3d976a9a
Autor:
Andrew E. Scott, Sarah A. Ngugi, Thomas R. Laws, David Corser, Claire L. Lonsdale, Riccardo V. D’Elia, Richard W. Titball, E. Diane Williamson, Timothy P. Atkins, Joann L. Prior
Publikováno v:
Journal of Immunology Research, Vol 2014 (2014)
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei. It is refractory to antibiotic treatment and there is currently no licensed vaccine. In this report we detail the construction and protective efficacy of a polysaccharide
Externí odkaz:
https://doaj.org/article/4b148131007d4b5cb25b8f4c6c672a8e
Autor:
Jon Cuccui, Rebecca M. Thomas, Madeleine G. Moule, Riccardo V. D'Elia, Thomas R. Laws, Dominic C. Mills, Diane Williamson, Timothy P. Atkins, Joann L. Prior, Brendan W. Wren
Publikováno v:
Open Biology, Vol 3, Iss 5 (2013)
Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant glycoc
Externí odkaz:
https://doaj.org/article/0f1409bae6b94cb78dcdd182ade53f11
Publikováno v:
Antimicrobial agents and chemotherapy. 66(11)
Burkholderia pseudomallei is the causative agent of melioidosis and presents with diverse clinical manifestations. Naturally occurring infection occurs following contamination of cuts or skin abrasions, or ingestion of contaminated water, and occasio
Autor:
E. Rayner, K. A. Clay, Julia Vipond, K. Godwin, Stuart J. Armstrong, M. G. Hartley, Isobel H. Norville, Timothy P. Atkins, Martha J. Bailey, Kevin R. Bewley
Publikováno v:
Antimicrobial Agents and Chemotherapy
Q fever, caused by the intracellular pathogen Coxiella burnetii, is traditionally treated using tetracycline antibiotics, such as doxycycline. Doxycycline is often poorly tolerated, and antibiotic-resistant strains have been isolated. In this study,
Autor:
Nicole M. Bzdyl, Geoffrey W. Coombs, Andrew E. Scott, Timothy J. J. Inglis, Nichollas E. Scott, Timothy P. Atkins, Mitali Sarkar-Tyson, Derek S. Sarovich, Isobel H. Norville, Charlene M. Kahler, Stanley Pang
Publikováno v:
Infection and Immunity. 87
Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic to Southeast Asia and northern Australia. Mortality rates in these areas are high even with antimicrobial treatment, and there are few options for effective therapy. T
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology
Frontiers in Microbiology
Historically, disease progression in animal models of Q fever has been carried out using PCR to monitor the presence of Coxiella burnetii DNA in the host. However, the colonization and dissemination of other bacterial infections in animal models are