Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Timothy P Spicer"'
Autor:
Evgeny G Chulkov, Emery Smith, Claudia M Rohr, Nawal A Yahya, Sang-Kyu Park, Louis Scampavia, Timothy P Spicer, Jonathan S Marchant
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009898 (2021)
Given the worldwide burden of neglected tropical diseases, there is ongoing need to develop novel anthelmintic agents to strengthen the pipeline of drugs to combat these burdensome infections. Many diseases caused by parasitic flatworms are treated u
Externí odkaz:
https://doaj.org/article/abaa115946af4e45b4a03469ea0cec2b
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181830 (2017)
Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes,
Externí odkaz:
https://doaj.org/article/9939f7dc96484658b89bc7627cbce5e3
Autor:
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly
Publikováno v:
eLife, Vol 5 (2016)
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genet
Externí odkaz:
https://doaj.org/article/42f2f67790644b3da9a9b3bdc96ee5c4
Autor:
Pamela Y Ting, Robert Damoiseaux, Björn Titz, Kenneth A Bradley, Thomas G Graeber, Virneliz Fernández-Vega, Thomas D Bannister, Peter Chase, Reji Nair, Louis Scampavia, Peter Hodder, Timothy P Spicer, John Colicelli
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121833 (2015)
Constitutively active BCR-ABL kinase fusions are causative mutations in the pathogenesis of hematopoietic neoplasias including chronic myelogenous leukemia (CML). Although these fusions have been successfully targeted with kinase inhibitors, drug-res
Externí odkaz:
https://doaj.org/article/2fdb029e4895452f97d6cb019cbf0f41
Autor:
Yuka Otsuka, Eunjung Kim, Austin Krueger, Justin Shumate, Chao Wang, Bilel Bdiri, Sultan Ullah, HaJeung Park, Louis Scampavia, Thomas D. Bannister, Donghoon Chung, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100180- (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for nearly 7 million deaths worldwide since its outbreak in late 2019. Even with the rapid development and production of vaccines and intensive research, there is still a hug
Externí odkaz:
https://doaj.org/article/bb6f58ce5e684354a6938ab8ae270651
Autor:
Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Ashley Cuell, Megan Tansiongco, Christina B. Cooley, Yanjun Chen, Agnieszka Dabrowska, Rahul Basu, Paulina Duhita Anindita, Dahai Luo, Peter I. Dosa, Daniel A. Harki, Thomas Bannister, Louis Scampavia, Timothy P. Spicer, Reuben S. Harris
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100181- (2024)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, SARS2) is responsible for the COVID-19 pandemic and infections that continue to affect the lives of millions of people worldwide, especially those who are older and/or immunocompromised. Th
Externí odkaz:
https://doaj.org/article/c4f7ebe12cd3480bb2ae4720b580813c
Autor:
Yuka Otsuka, Lizhou Zhang, Huihui Mou, Justin Shumate, Claire E. Kitzmiller, Louis Scampavia, Thomas D. Bannister, Michael Farzan, Hyeryun Choe, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100178- (2024)
Emerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) cente
Externí odkaz:
https://doaj.org/article/11c7a571d55c43108e85b47fce35be0e
Autor:
Paulina Duhita Anindita, Yuka Otsuka, Simon Lattmann, Khac Huy Ngo, Chong Wai Liew, CongBao Kang, Reuben S. Harris, Louis Scampavia, Timothy P. Spicer, Dahai Luo
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100164- (2024)
Zika virus (ZIKV) continues to pose a significant global public health threat, with recurring regional outbreaks and potential for pandemic spread. Despite often being asymptomatic, ZIKV infections can have severe consequences, including neurological
Externí odkaz:
https://doaj.org/article/08f9bcf98354450598cb5479a707e904
Autor:
Luis M. Ortiz Jordan, Virneliz Fernández Vega, Justin Shumate, Adam Peles, Jordan Zeiger, Louis Scampavia, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100141- (2024)
High Throughput Screening (HTS) with 3D cell models is possible thanks to the recent progress and development in 3D cell culture technologies. Results from multiple studies have demonstrated different drug responses between 2D and 3D cell culture. It
Externí odkaz:
https://doaj.org/article/482d07966d634fcfad48ee4a6637718a
Autor:
Emery Smith, Louise Dickson, Philip Pickford, Anna Rowland, Justin Shumate, Katherine Perez, Louis Scampavia, Derek Hernandez, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100148- (2024)
Fluorescence-based potassium channel assays are typically run on expensive, hard to obtain, fluorescence imaging kinetic plate readers that are uncommon in most laboratories. Here we describe the use of the Brilliant Thallium Snapshot assay to conduc
Externí odkaz:
https://doaj.org/article/d63f38c596484ee7b706acbe9450ce48