Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Timothy P Padera"'
Autor:
Gabriel Gruionu, James Baish, Sean McMahon, David Blauvelt, Lucian G. Gruionu, Mara Onita Lenco, Benjamin J. Vakoc, Timothy P. Padera, Lance L. Munn
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Overly dense microvascular networks are treated by selective reduction of vascular elements. Inappropriate manipulation of microvessels could result in loss of host tissue function or a worsening of the clinical problem. Here, experimental,
Externí odkaz:
https://doaj.org/article/74e1fc27144d46779a5d8f1a2d848d30
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer dissemination to lymph nodes (LN) is associated with a worse prognosis, increased incidence of distant metastases and reduced response to therapy. The LN microenvironment puts selective pressure on cancer cells, creating cells that can survive
Externí odkaz:
https://doaj.org/article/05caf73543d24bddbf8b829a2632ebbc
Publikováno v:
Advanced Science, Vol 10, Iss 36, Pp n/a-n/a (2023)
Abstract Effective anti‐cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Her
Externí odkaz:
https://doaj.org/article/d5fbc98e2d0542fe95abdabc696c7864
Autor:
Lance L Munn, Mohammad R Nikmaneshi, Laurel B Darragh, Sana D Karam, Pinji Lei, Hengbo Zhou, Meghan J O’Melia, James W Baish, Lutz Menzel, Johanna J Rajotte, Mohammad S Razavi Rizi, Matthew G Vander Heiden, Timothy P Padera
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c6e1acbf087946179d227bb69b62a486
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Edema in the limbs can arise from pathologies such as elevated capillary pressures due to failure of venous valves, elevated capillary permeability from local inflammation, and insufficient fluid clearance by the lymphatic system. The most c
Externí odkaz:
https://doaj.org/article/b035c8446d594c8cac422e5ce8a2de18
Autor:
Dhruv Singhal, Katy Börner, Elliot L. Chaikof, Michael Detmar, Maija Hollmén, Jeffrey J. Iliff, Maxim Itkin, Taija Makinen, Guillermo Oliver, Timothy P. Padera, Ellen M. Quardokus, Andrea J. Radtke, Hiroo Suami, Griffin M. Weber, Ilsa I. Rovira, Selen C. Muratoglu, Zorina S. Galis
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues and organs within the body and contributes t
Externí odkaz:
https://doaj.org/article/f06e8c8860c443b8a0d21169c38646e5
Autor:
Nicola C. Frenkel, Susanna Poghosyan, André Verheem, Timothy P. Padera, Inne H. M. Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the
Externí odkaz:
https://doaj.org/article/83a9268bbc9c4e1cb850f89e226f267c
Autor:
John D. Martin, Ryan M. Lanning, Vikash P. Chauhan, Margaret R. Martin, Ahmed S. Mousa, Walid S. Kamoun, Hee-Sun Han, Hang Lee, Triantafyllos Stylianopoulos, Moungi G. Bawendi, Dan G. Duda, Edward B. Brown, Timothy P. Padera, Dai Fukumura, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 28:3076-3090
Purpose: The abnormal function of tumor blood vessels causes tissue hypoxia, promoting disease progression and treatment resistance. Although tumor microenvironment normalization strategies can alleviate hypoxia globally, how local oxygen levels chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4a5363475591f35309b16beae72815
https://doi.org/10.1158/1078-0432.ccr-22-0486
https://doi.org/10.1158/1078-0432.ccr-22-0486
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/892c48082d344386ac2fa9cc4b4ca9cc
Autor:
Rakesh K. Jain, Dai Fukumura, Kevin R. Kozak, Jennifer Lobo, Shan Liao, Tohru Hoshida, Angera H. Kuo, Timothy P. Padera
Blood vessels are required for a tumor to grow and functional lymphatic vessels are required for it to disseminate to lymph nodes. In an attempt to eradicate both the primary tumor and its lymphatic metastasis, we targeted both blood and lymphatic ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c8b163b2a7acad36aef29676556a6f
https://doi.org/10.1158/1535-7163.c.6531720.v1
https://doi.org/10.1158/1535-7163.c.6531720.v1
