Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Timothy P Newton"'
Autor:
Todd M Pitts, Timothy P Newton, Erica L Bradshaw-Pierce, Rebecca Addison, John J Arcaroli, Peter J Klauck, Stacey M Bagby, Stephanie L Hyatt, Alicia Purkey, John J Tentler, Aik Choon Tan, Wells A Messersmith, S Gail Eckhardt, Stephen Leong
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113037 (2014)
The activation of the MAPK and PI3K/AKT/mTOR pathways is implicated in the majority of cancers. Activating mutations in both of these pathways has been described in colorectal cancer (CRC), thus indicating their potential as therapeutic targets. This
Externí odkaz:
https://doaj.org/article/b1c9a4e1dffc414aa91616e478557aca
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6c94fd7b52ea25faa4f7d730cf7869
https://doi.org/10.1158/1535-7163.22501969.v1
https://doi.org/10.1158/1535-7163.22501969.v1
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Table 4: Combination Index (CI) Values. CI values calculated using the Chou and Talalay method from SRB proliferation data for varying concentrations of Nutlin and MLN8237 in combination. CI < 1 indicates synergy; CI = 1 additivity; CI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff9f10b0d9257be68f2433ea62214db
https://doi.org/10.1158/1535-7163.22501957.v1
https://doi.org/10.1158/1535-7163.22501957.v1
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Figure 2. Quantification of total cell counts and average cellular size at Day 15 as depicted in Fig. 4A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6079b56c8543f0b8c180350d425644a3
https://doi.org/10.1158/1535-7163.22501981.v1
https://doi.org/10.1158/1535-7163.22501981.v1
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Table 3: Quantification of total cell counts and average cellular size under conditions depicted in Fig. 4A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553a7f4799d8473a8ce06bf3efddbaed
https://doi.org/10.1158/1535-7163.22501960.v1
https://doi.org/10.1158/1535-7163.22501960.v1
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Figure 4. Effect of MLN8237 on Cleaved Caspase-3 in TNBC xenografts in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc5edf66429b6ed438866fcab70ac32
https://doi.org/10.1158/1535-7163.22501972.v1
https://doi.org/10.1158/1535-7163.22501972.v1
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Supplementary Data from Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66cc0ba3e4bb3154d809f1ce9e18868
https://doi.org/10.1158/1535-7163.22522086
https://doi.org/10.1158/1535-7163.22522086
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Figure 1. Treatment with MLN8237 induces markers of cellular senescence in two additional CAL-51 p53 and p73 shRNA knockdown clones (p53-12, p73-26).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22e9ce8a395e66562041aa1c033dc3
https://doi.org/10.1158/1535-7163.22501987.v1
https://doi.org/10.1158/1535-7163.22501987.v1
Autor:
Jennifer R. Diamond, S. Gail Eckhardt, Joaquin M. Espinosa, Kelly D. Sullivan, Carol A. Sartorius, Peter Kabos, Magdalena J. Glogowska, Todd M. Pitts, Timothy P. Newton, Aik Choon Tan, Anastasia A. Ionkina, John J. Tentler
Supplementary Table 2: Sensitivity of CAL-51 KD clones to MLN8237 in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c21b9959f1da3e3b0ac97271a555cd
https://doi.org/10.1158/1535-7163.22501963
https://doi.org/10.1158/1535-7163.22501963
Autor:
Anthony D. Piscopio, Xuedong Liu, S. Gail Eckhardt, William P. Schiemann, Michael K. Wendt, James D. Winkler, John A. DeMattei, Sarah J. Hartman, Brian Gittleman, John J. Tentler, Timothy P. Newton, Betelehem W. Yacob, Jessica Pafford, Stacey M. Bagby, Andrew J. Phillips, Gan Zhang, Christopher G. Nasveschuk, Dana Ungermannova, Todd M. Pitts, Jennifer R. Diamond
Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. Although HDAC inhibitors are active in T-cell lymphomas, poor isoform selectivity, narrow therapeutic indices, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca10d3d7a768f89abeba39b0600ff66
https://doi.org/10.1158/1535-7163.c.6543273
https://doi.org/10.1158/1535-7163.c.6543273