Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Timothy P Newsome"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012423 (2024)
The extent and origin of variation in the replication dynamics of complex DNA viruses is not well-defined. Here, we investigate the vaccinia virus (VACV) infection cycle at the single-cell level, quantifying the temporal dynamics of early and post(dn
Externí odkaz:
https://doaj.org/article/05531bf5d46543cd949a4195a88f02f3
Autor:
Isaac G Sakala, Geeta Chaudhri, Anthony A Scalzo, Preethi Eldi, Timothy P Newsome, Robert M Buller, Gunasegaran Karupiah
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005342 (2015)
Orthopoxviruses (OPV), including variola, vaccinia, monkeypox, cowpox and ectromelia viruses cause acute infections in their hosts. With the exception of variola virus (VARV), the etiological agent of smallpox, other OPV have been reported to persist
Externí odkaz:
https://doaj.org/article/cea6de08645b4ef199a3c893657675ec
Autor:
Jacquelyn Horsington, Helena Lynn, Lynne Turnbull, Delfine Cheng, Filip Braet, Russell J Diefenbach, Cynthia B Whitchurch, Guna Karupiah, Timothy P Newsome
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003239 (2013)
Cell-to-cell transmission of vaccinia virus can be mediated by enveloped virions that remain attached to the outer surface of the cell or those released into the medium. During egress, the outer membrane of the double-enveloped virus fuses with the p
Externí odkaz:
https://doaj.org/article/a1b13067aad24f0aa44f242e10413aa7
Autor:
Anupriya Aggarwal, Tina L Iemma, Ivy Shih, Timothy P Newsome, Samantha McAllery, Anthony L Cunningham, Stuart G Turville
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002762 (2012)
Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane b
Externí odkaz:
https://doaj.org/article/5a0c17ebecea4f0d8243b1dff02bda93
Autor:
Jürg Berger, Kirsten-André Senti, Gabriele Senti, Timothy P Newsome, Bengt Asling, Barry J Dickson, Takashi Suzuki
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000085 (2008)
Forward genetic screens in model organisms are an attractive means to identify those genes involved in any complex biological process, including neural circuit assembly. Although mutagenesis screens are readily performed to saturation, gene identific
Externí odkaz:
https://doaj.org/article/8f8fbca0e1fd45f9ac3c86f05e3891ed
Autor:
Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April Van Der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/d6c7d0d84f3d4d78be8859af3bbe8cc3
Publikováno v:
Journal of cell science. 136(5)
Intracellular mature viruses (IMVs) are the first and most abundant infectious form of vaccinia virus to assemble during its replication cycle. IMVs can undergo microtubule-based motility, but their directionality and the motor involved in their tran
Autor:
Timothy P. Newsome, Caitlin R. Abbott
Publikováno v:
Dev Cell
Intracellular pathogens alter their host cell mechanics to promote dissemination through tissues. Conversely, host cells may respond to the presence of pathogens by altering their mechanics to limit infection. Here, we monitored epithelial cell monol
Autor:
Geeta Chaudhri, Gunasegaran Karupiah, Heinrich Körner, Timothy P. Newsome, Pratikshya Pandey, Sigrid R. Ruuls, Esther Ng, Ma Junaliah Tuazon Kels, Zahrah Al Rumaih
Publikováno v:
Proc Natl Acad Sci U S A
Excessive tumor necrosis factor (TNF) is known to cause significant pathology. Paradoxically, deficiency in TNF (TNF(−/−)) also caused substantial pathology during respiratory ectromelia virus (ECTV) infection, a surrogate model for smallpox. TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e16607d5b759a2a39ba9c47c2bf63e0
Autor:
Sharissa L. Latham, N. Bishara Marzook, Georges E. Grau, Christopher McKenzie, Christine Chaponnier, Timothy P. Newsome, Helena Lynn
Publikováno v:
Cytoskeleton. 74:170-183
Actin is a major component of the cytoskeleton and is present as two isoforms in non-muscle cells: β- and γ-cytoplasmic actin. These isoforms are strikingly conserved, differing by only four N-terminal amino acids. During spread from infected cells