Zobrazeno 1 - 10
of 401
pro vyhledávání: '"Timothy P, Stinear"'
Autor:
Heran Zhang, Ian R. Monk, Jessica Braverman, Claerwen M. Jones, Andrew G. Brooks, Timothy P. Stinear, Linda M. Wakim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Superantigens (sAgs) are bacterial virulence factors that induce a state of immune hyperactivation by forming a bridge between certain subsets of T cell receptor (TCR) β chains on T lymphocytes, and class II major histocompatibility complex
Externí odkaz:
https://doaj.org/article/c05a1fab140c4c649629a5df6a0761ef
Autor:
Kim R. Blasdell, Richard J. Ploeg, Emma C. Hobbs, Stephen Muhi, Sarah J. Riddell, Alexandra Cunneen, Michael L. Kelly, Kate Maynard, Tess R. Malcolm, Md. Tanjir Islam, Victoria Boyd, Timothy P. Stinear, Sacha J. Pidot, Eugene Athan, Daniel P. O’Brien
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Buruli ulcer (BU) is a necrotizing disease of skin and soft tissue caused by the bacterium Mycobacterium ulcerans (MU). In Australia, where the disease is emerging in new geographic areas and human case numbers are increasing, native possum
Externí odkaz:
https://doaj.org/article/bb97b88c1e6a4174bf8856af982849ed
Autor:
Jacob Fry, Jean Y. H. Lee, Julie L. McAuley, Jessica L. Porter, Ian R. Monk, Samuel T. Martin, David J. Collins, Gregory J. Barbante, Nicholas J. Fitzgerald, Timothy P. Stinear
Publikováno v:
ACS Omega, Vol 9, Iss 39, Pp 40832-40840 (2024)
Externí odkaz:
https://doaj.org/article/d450b3169bef4deb8b65be3fa933a452
Autor:
Andrew H. Buultjens, Ee Laine Tay, Aidan Yuen, N. Deborah Friedman, Timothy P. Stinear, Paul D.R. Johnson
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1918-1921 (2024)
Alphavirus infections are transmitted by mosquitoes, but the mode of transmission for Mycobacterium ulcerans, which causes Buruli ulcer, is contested. Using notification data for Victoria, Australia, during 2017–2022, adjusted for incubation period
Externí odkaz:
https://doaj.org/article/74775c7474464dc0a4691ff08d16f81f
Autor:
Emma C Hobbs, Jessica L Porter, Jean Y H Lee, Panayiotis Loukopoulos, Pam Whiteley, Lee F Skerratt, Timothy P Stinear, Katherine B Gibney, Anna L Meredith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 11, p e0012189 (2024)
Buruli ulcer (BU) is a neglected tropical disease of skin and subcutaneous tissues caused by Mycobacterium ulcerans. BU-endemic areas are highly focal, and M. ulcerans transmission dynamics vary by setting. In Victoria, Australia, BU is an endemic ve
Externí odkaz:
https://doaj.org/article/d6d779a1ac4a443abe5191cf5f134083
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/c3b3819748b94938bdc0ba761aa200a3
Autor:
Michael B Hall, Ryan R Wick, Louise M Judd, An N Nguyen, Eike J Steinig, Ouli Xie, Mark Davies, Torsten Seemann, Timothy P Stinear, Lachlan Coin
Publikováno v:
eLife, Vol 13 (2024)
Variant calling is fundamental in bacterial genomics, underpinning the identification of disease transmission clusters, the construction of phylogenetic trees, and antimicrobial resistance detection. This study presents a comprehensive benchmarking o
Externí odkaz:
https://doaj.org/article/cd1d06c346284d23b31c3ead2e1180fc
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/edc943f8fc3e49d9b390671211b87caf
Autor:
Sacha J Pidot, Stephan Klatt, Louis S Ates, Wafa Frigui, Fadel Sayes, Laleh Majlessi, Hiroshi Izumi, Ian R Monk, Jessica L Porter, Vicki Bennett-Wood, Torsten Seemann, Ashley Otter, George Taiaroa, Gregory M Cook, Nicholas West, Nicholas J Tobias, John A Fuerst, Michael D Stutz, Marc Pellegrini, Malcolm McConville, Roland Brosch, Timothy P Stinear
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012440 (2024)
Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that have led to the tubercle bacillus becoming such a formidable human pathogen. Here we report t
Externí odkaz:
https://doaj.org/article/c05a679dcd724c87b14f99cec3647995
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT A Mycobacterium ulcerans human challenge model has the potential to fundamentally advance our understanding of early human immune responses to infection, while rapidly evaluating vaccines and other therapeutic interventions. Here, using a mu
Externí odkaz:
https://doaj.org/article/1371de957a9843479eeb23187d729adc