Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Timothy P, Spicer"'
Autor:
Yuka Otsuka, Eunjung Kim, Austin Krueger, Justin Shumate, Chao Wang, Bilel Bdiri, Sultan Ullah, HaJeung Park, Louis Scampavia, Thomas D. Bannister, Donghoon Chung, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100180- (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for nearly 7 million deaths worldwide since its outbreak in late 2019. Even with the rapid development and production of vaccines and intensive research, there is still a hug
Externí odkaz:
https://doaj.org/article/bb6f58ce5e684354a6938ab8ae270651
Autor:
Renee Delgado, Jyoti Vishwakarma, Seyed Arad Moghadasi, Yuka Otsuka, Justin Shumate, Ashley Cuell, Megan Tansiongco, Christina B. Cooley, Yanjun Chen, Agnieszka Dabrowska, Rahul Basu, Paulina Duhita Anindita, Dahai Luo, Peter I. Dosa, Daniel A. Harki, Thomas Bannister, Louis Scampavia, Timothy P. Spicer, Reuben S. Harris
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100181- (2024)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, SARS2) is responsible for the COVID-19 pandemic and infections that continue to affect the lives of millions of people worldwide, especially those who are older and/or immunocompromised. Th
Externí odkaz:
https://doaj.org/article/c4f7ebe12cd3480bb2ae4720b580813c
Autor:
Yuka Otsuka, Lizhou Zhang, Huihui Mou, Justin Shumate, Claire E. Kitzmiller, Louis Scampavia, Thomas D. Bannister, Michael Farzan, Hyeryun Choe, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100178- (2024)
Emerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) cente
Externí odkaz:
https://doaj.org/article/11c7a571d55c43108e85b47fce35be0e
Autor:
Paulina Duhita Anindita, Yuka Otsuka, Simon Lattmann, Khac Huy Ngo, Chong Wai Liew, CongBao Kang, Reuben S. Harris, Louis Scampavia, Timothy P. Spicer, Dahai Luo
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100164- (2024)
Zika virus (ZIKV) continues to pose a significant global public health threat, with recurring regional outbreaks and potential for pandemic spread. Despite often being asymptomatic, ZIKV infections can have severe consequences, including neurological
Externí odkaz:
https://doaj.org/article/08f9bcf98354450598cb5479a707e904
Autor:
Luis M. Ortiz Jordan, Virneliz Fernández Vega, Justin Shumate, Adam Peles, Jordan Zeiger, Louis Scampavia, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100141- (2024)
High Throughput Screening (HTS) with 3D cell models is possible thanks to the recent progress and development in 3D cell culture technologies. Results from multiple studies have demonstrated different drug responses between 2D and 3D cell culture. It
Externí odkaz:
https://doaj.org/article/482d07966d634fcfad48ee4a6637718a
Autor:
Emery Smith, Louise Dickson, Philip Pickford, Anna Rowland, Justin Shumate, Katherine Perez, Louis Scampavia, Derek Hernandez, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100148- (2024)
Fluorescence-based potassium channel assays are typically run on expensive, hard to obtain, fluorescence imaging kinetic plate readers that are uncommon in most laboratories. Here we describe the use of the Brilliant Thallium Snapshot assay to conduc
Externí odkaz:
https://doaj.org/article/d63f38c596484ee7b706acbe9450ce48
A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
Autor:
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Ritika Gangaraju, Nitin Sai Beesabathuni, Martin Jean Kim, Qi Tian, Priya S. Shah, Louis Scampavia, Timothy P. Spicer, Chang-Il Hwang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-11 (2023)
Abstract Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involve
Externí odkaz:
https://doaj.org/article/9724ab7f7f6f42e8a12f619770e9bc57
Autor:
Emery Smith, Meredith E. Davis-Gardner, Ruben D. Garcia-Ordonez, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Xuerong Yu, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Patrick Griffin, Michael Farzan, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 95-101 (2023)
The SARS coronavirus 2 (SARS-CoV-2) pandemic remains a major problem in many parts of the world and infection rates remain at extremely high levels. This high prevalence drives the continued emergence of new variants, and possibly ones that are more
Externí odkaz:
https://doaj.org/article/db1e32100b2d4082831f28774739da29
Autor:
Virneliz Fernández Vega, Dong Yang, Luis Ortiz Jordán, Fei Ye, Louis Conway, Li Yun Chen, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Christopher Parker, Ben Shen, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 28, Iss 2, Pp 20-28 (2023)
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and accounts for ∼84% of all lung cancer cases. NSCLC remains one of the leading causes of cancer-associated death, with a 5-year survival rate less than 25%. This type of ca
Externí odkaz:
https://doaj.org/article/3e49c444351c49eaa92e3aaa15039015
Autor:
Shurong Hou, Zhenzhen Li, Xiaoling Chen, Wenxin Wang, Ting Duan, Louis Scampavia, Yaxia Yuan, Timothy P. Spicer, Xiabin Chen, Tian Xie
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/157943dffabf466b9d6667c6532ef133