Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Timothy P, Fleming"'
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Alexa Guerrero-Alba, Sandhya Bansal, Aryan N. Sankpal, Geetanjali Mitra, Mohammad Rahman, Ranjithkumar Ravichandran, Christin Poulson, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, T. Mohanakumar, Narendra V. Sankpal
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
In the realm of biomedical advancement, extracellular vesicles (EVs) are revolutionizing our capacity to diagnose, monitor, and predict disease progression. However, the comprehensive exploration and clinical application of EVs face significant limit
Externí odkaz:
https://doaj.org/article/c2b1881291d84e4ab010a63039134313
Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1.
Autor:
Fatma A Omar, Taylor C Brown, William E Gillanders, Timothy P Fleming, Michael A Smith, Ross M Bremner, Narendra V Sankpal
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285707 (2023)
Next generation sequencing of human cancer mutations has identified novel therapeutic targets. Activating Ras oncogene mutations play a central role in oncogenesis, and Ras-driven tumorigenesis upregulates an array of genes and signaling cascades tha
Externí odkaz:
https://doaj.org/article/829f1e9066864c72ad1fb7a926411f03
Autor:
Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd, William E. Gillanders
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demon
Externí odkaz:
https://doaj.org/article/38b6284507a6410392762012b6929067
Autor:
Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufac
Externí odkaz:
https://doaj.org/article/031af79ff43e4bff85ce49e20a87cccb
Autor:
William E. Gillanders, S. Peter Goedegebuure, Timothy P. Fleming, Ted Hansen, Elaine R. Mardis, Matthew J. Ellis, Chris A. Miller, Ian S. Hagemann, Mark Sturmoski, Tammi L. Vickery, Nancy Myers, Tina Primeau, Jeremy Hoog, Mike D. McLellan, Lijin Li, Savas D. Soysal, Allegra A. Petti, Shunqiang Li, John M. Herndon, Jasreet Hundal, Samuel Kim, Xiuli Zhang
Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in human breast cancers. Using patient-derived xenografts from three patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373d4a0c05b6ed776184bd81daf3d8a0
https://doi.org/10.1158/2326-6066.c.6548891
https://doi.org/10.1158/2326-6066.c.6548891
PDF file - 108K, EpCAM and IL-8 microarray expression data from 1881 breast cancer plotted in box plot.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4d5de426ffad063be82edf1f652fb
https://doi.org/10.1158/1541-7786.22516965
https://doi.org/10.1158/1541-7786.22516965
PDF file - 26K, Mutating IL-8 promoter at AP-1 and NF-kB binding ssites shows NF-kB is dominant player for IL-8 transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014e0c9817abab6fc5fa7435e50cb67c
https://doi.org/10.1158/1541-7786.22516953
https://doi.org/10.1158/1541-7786.22516953
PDF file - 27K, EpCAM and or IL-8 knockdown decreased matrigel invasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4d16a12fd73a63143de1d49fd24069
https://doi.org/10.1158/1541-7786.22516956.v1
https://doi.org/10.1158/1541-7786.22516956.v1
PDF file - 23K, EpCAM knockdown in MCF-7 decreased IL-8 expression after IL1b stimulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0cc5906c58c35eaf0b4bb1500dcdb3
https://doi.org/10.1158/1541-7786.22516959.v1
https://doi.org/10.1158/1541-7786.22516959.v1