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pro vyhledávání: '"Timothy O. Josephson"'
Autor:
Timothy O. Josephson, Elise F. Morgan
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
At the macroscale, bones experience a variety of compressive and tensile loads, and these loads cause deformations of the cortical and trabecular microstructure. These deformations produce a variety of stimuli in the cellular microenvironment that ca
Externí odkaz:
https://doaj.org/article/694da2326ef84396b54cbfeeca305ad9
Publikováno v:
Computer Methods in Biomechanics and Biomedical Engineering. 25:342-357
Developing advanced fracture tools can increase the understanding of crack growth trajectories in human cortical bone. The present study investigates fracture micromechanics of human cortical bone under compressive and tensile loadings utilizing a ph
Publikováno v:
Journal of the mechanical behavior of biomedical materials. 126
The mechanical behavior of cortical bone is influenced by microstructural components such as osteons, Haversian canals, and osteocyte lacunae that arise from biological remodeling processes. This study takes a computational approach to investigate th
Autor:
Lamya Karim, Timothy O. Josephson, Ahmad R. Najafi, Jason P. Moore, Ebrahim Maghami, Theresa A. Freeman, Taraneh Rezaee
Publikováno v:
Journal of biomechanics. 125
Diabetes is associated with increased fracture risk in human bone, especially in the elderly population. In the present study, we investigate how simulated advanced glycation end-products (AGEs) and materials heterogeneity affect crack growth traject