Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Timothy Nowak"'
Autor:
Michael Wleklinski, Paige M. Carpenter, Kevin D. Dykstra, Anthony Donofrio, Timothy Nowak, Shane W. Krska, Ronald D. Ferguson
Publikováno v:
SLAS Technology, Vol 29, Iss 2, Pp 100126- (2024)
High-throughput experimentation (HTE) has become more widely utilized in drug discovery for rapid reaction optimization and generation of large synthetic compound arrays. While this has accelerated medicinal chemistry design, make, test (DMT) iterati
Externí odkaz:
https://doaj.org/article/551f9a876fc040d694b69bd9e46488ad
Autor:
Sebastian Wöllner, Timothy Nowak, Dr. Gui‐Rong Zhang, Dr. Nils Rockstroh, Dr. Hanadi Ghanem, Prof. Dr. Stefan Rosiwal, Prof. Dr. Angelika Brückner, Prof. Dr. Bastian J. M. Etzold
Publikováno v:
ChemistryOpen, Vol 10, Iss 5, Pp 600-606 (2021)
Abstract Electrocatalytic oxidation of 5‐hydroxymethylfurfural (HMF) offers a renewable approach to produce the value‐added platform chemical 2,5‐furandicarboxylic acid (FDCA). The key for the economic viability of this approach is to develop a
Externí odkaz:
https://doaj.org/article/b2f88b72541e474ab914243f2863cbd7
Autor:
Cesar N. Prieto Kullmer, Jacob A. Kautzky, Shane W. Krska, Timothy Nowak, Spencer D. Dreher, David W. C. MacMillan
Publikováno v:
Science
Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. We develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7dedbb311cdaed9d29c74bd68fb545
https://doi.org/10.1126/science.abn1885
https://doi.org/10.1126/science.abn1885
Publikováno v:
ACS Catalysis. 12:3201-3210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170275bdc2c12a6fbd5946ffe8d11567
https://doi.org/10.1021/acscatal.1c05502
https://doi.org/10.1021/acscatal.1c05502
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
Publikováno v:
Analytical Chemistry. 92:13443-13451
Modern pharmaceutical processes can often lead to multicomponent mixtures of closely related species that are difficult to resolve under chromatographic conditions, and even worse in preparative scale settings. Despite recent improvements in column t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f8469d60d45ed45c09cea422711e50
https://doi.org/10.1021/acs.analchem.0c02807
https://doi.org/10.1021/acs.analchem.0c02807
Autor:
Debopreeti Mukherjee, Pablo Trigo‐Mouriño, Yuan Jiang, Timothy Nowak, Vladimir Shchurik, Donovon A. Adpressa, Michael T. Louie, Shane R. Reynolds, Michael J. Hohn, Mohammad Ahmed Al‐Sayah, Gregory F. Pirrone, Alexey A. Makarov
Publikováno v:
Journal of separation scienceREFERENCES. 45(12)
Recent advances in the field of cancer biology have accelerated the discovery and development of novel biopharmaceuticals. At the forefront of these drug development efforts are high-throughput screening, compressed timelines, and limited sample quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e8521b94f66bad132673db826806ee
https://pubmed.ncbi.nlm.nih.gov/35108448
https://pubmed.ncbi.nlm.nih.gov/35108448
Autor:
Xingshuo Chen, Zhenwei Wei, Kai‐Hung Huang, Mycah Uehling, Michael Wleklinski, Shane Krska, Alexey A. Makarov, Timothy Nowak, R. Graham Cooks
Publikováno v:
ChemPlusChem. 87(3)
Palladium-catalyzed Suzuki-Miyaura (SM) coupling is widely utilized in the construction of carbon-carbon bonds. In this study, nanoelectrospray ionization mass spectrometry (nanoESI-MS) is applied to simultaneously monitor precatalysts, catalytic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ceb456aa4530bc08eedfdfe2e90a92c
https://pubmed.ncbi.nlm.nih.gov/35112808
https://pubmed.ncbi.nlm.nih.gov/35112808
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 165:366-373
Within the pharmaceutical industry, the determination of residual solvents by Gas Chromatography Flame Ionization Detection (GC-FID) is a highly utilized analytical test that often employs helium (He) as the carrier gas. However, many do not realize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c374ef6e8b90a87122f9e0d7d763bfb
https://doi.org/10.1016/j.jpba.2018.12.006
https://doi.org/10.1016/j.jpba.2018.12.006
Autor:
Raffeal Bennett, Ian Mangion, Gregory F. Pirrone, Erik L. Regalado, Debopreeti Mukherjee, Alexey A. Makarov, Timothy Nowak, Claudio Mapelli, Jennifer L. Hickey, Vladimir Shchurik
Publikováno v:
Analytica chimica acta. 1142
At the forefront of synthetic endeavors in the pharmaceutical industry, including drug discovery and high-throughput screening, timelines are tight and large quantities of pure chemical targets are rarely available. In this regard, the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5999d2706794a3ac4e4abb59d7f43c4
https://pubmed.ncbi.nlm.nih.gov/33280687
https://pubmed.ncbi.nlm.nih.gov/33280687