Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Timothy Neubert"'
Autor:
Dean Stamos, Michael Liu, Beth Fleck, Lance Goulet, Weichao Chen, Harmon J. Zuccola, Phillip W. Snyder, Dao Tran, Peggy Chiang, James Reynolds, Azin Nezami, Samuel Sperry, Khisal Ahmed Alvi, Alcacio Timothy, Lisa Woody, William Kargo, Amy Turnbull, Timothy Neubert, Justin T. Ernst
Publikováno v:
Journal of Medicinal Chemistry. 57:3382-3400
A structure-based drug design strategy was used to optimize a novel benzolactam series of HSP90α/β inhibitors to achieve >1000-fold selectivity versus the HSP90 endoplasmic reticulum and mitochondrial isoforms (GRP94 and TRAP1, respectively). Selec
Autor:
Harmon J. Zuccola, Bryan W. Vought, Michael Liu, Justin T. Ernst, E. Adam Kallel, Timothy Neubert, Amy Turnbull, Kevin Beaumont, Dean Stamos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:204-208
HSP90 continues to be a target of interest for neurodegeneration indications. Selective knockdown of the HSP90 cytosolic isoforms α and β is sufficient to reduce mutant huntingtin protein levels in vitro. Chemotype-dependent binding conformations o
Publikováno v:
ChemInform. 46
A radical mediated C–H functionalization of 3,6-dichloropyridazine using primary alcohols, t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step c
Publikováno v:
Organic letters. 17(10)
A radical mediated C–H functionalization of 3,6-dichloropyridazine using primary alcohols, t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step c
Autor:
Timothy Neubert, Timothy Coon, Brett B. Busch, Justin T. Ernst, Paul Krenitsky, Leonard Kaljevic, Edwin Schweiger, Andreas Termin, Jeremy J. Clemens, Dean Stamos, Juliana L. Asgian
Publikováno v:
The Journal of organic chemistry. 78(2)
Efforts to substitute the cyclopropane ring in a series of aryl cyclopropylnitriles led to the discovery of an operationally simple one-pot method for Knoevenagel condensation and subsequent Corey-Chaykovsky cyclopropanation giving diastereomerically