Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Timothy Nacarelli"'
Autor:
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inf
Externí odkaz:
https://doaj.org/article/f687034dd13c48c997ad226023ef1a47
Autor:
Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, Andrew Kossenkov, Timothy Nacarelli, Sanki Tashiro, Sonali Majumdar, Louise C. Showe, Rugang Zhang, Ken-ichi Noma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Cell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily t
Externí odkaz:
https://doaj.org/article/d6bfd9f78d8e46fe944d870a5010386b
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively s
Externí odkaz:
https://doaj.org/article/fd33df24253642d4aa5485f064341ede
Autor:
Takeshi Fukumoto, Pyoung Hwa Park, Shuai Wu, Nail Fatkhutdinov, Sergey Karakashev, Timothy Nacarelli, Andrew V. Kossenkov, David W. Speicher, Stephanie Jean, Lin Zhang, Tian-Li Wang, Ie-Ming Shih, Jose R. Conejo-Garcia, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3393-3400 (2018)
Summary: ARID1A, a subunit of the SWI/SNF complex, is among the most frequently mutated genes across cancer types. ARID1A is mutated in more than 50% of ovarian clear cell carcinomas (OCCCs), diseases that have no effective therapy. Here, we show tha
Externí odkaz:
https://doaj.org/article/c03c4b3064504442808ca962aa2f53e5
Autor:
Timothy Nacarelli, Rugang Zhang
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence. This newly discovered epigenetic-metabolic signaling axis, mediated by h
Externí odkaz:
https://doaj.org/article/1738997de1db4878bcf73e0ecf35b916
Autor:
Rugang Zhang, Mark E. Borowsky, Mark G. Cadungog, Stephanie Jean, Nail Fatkhutdinov, Joseph A. Zundell, Takeshi Fukumoto, Timothy Nacarelli
Figure S6 shows that conditioned media is not sufficient to induce senescence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f87cc5aed67e4fef4962df5c46f940
https://doi.org/10.1158/0008-5472.22425367.v1
https://doi.org/10.1158/0008-5472.22425367.v1
Autor:
Rugang Zhang, Mark E. Borowsky, Mark G. Cadungog, Stephanie Jean, Nail Fatkhutdinov, Joseph A. Zundell, Takeshi Fukumoto, Timothy Nacarelli
Figure S2 shows that NAMPT inhibition suppresses the SASP induced by carboplatin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43887e6b8a90cde141338eea37c4e7b7
https://doi.org/10.1158/0008-5472.22425379.v1
https://doi.org/10.1158/0008-5472.22425379.v1
Autor:
Rugang Zhang, Shuai Wu, Chih-Chi Andrew Hu, Joel Cassel, Qin Liu, Andrew V. Kossenkov, Timothy Nacarelli, Nail Fatkhudinov, Jianhuang Lin, Takeshi Fukumoto, Joseph A. Zundell
Figure S6 shows that B-I09 and ACY1215 combination is well tolerated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60620c22020e11f198d36b27bd2fa533
https://doi.org/10.1158/0008-5472.22430353.v1
https://doi.org/10.1158/0008-5472.22430353.v1
Autor:
Rugang Zhang, Mark E. Borowsky, Mark G. Cadungog, Stephanie Jean, Nail Fatkhutdinov, Joseph A. Zundell, Takeshi Fukumoto, Timothy Nacarelli
Legends for supplementary figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c9458c85cf903db8c143443cf6b20
https://doi.org/10.1158/0008-5472.22425358.v1
https://doi.org/10.1158/0008-5472.22425358.v1
Autor:
Rugang Zhang, Mark E. Borowsky, Mark G. Cadungog, Stephanie Jean, Nail Fatkhutdinov, Joseph A. Zundell, Takeshi Fukumoto, Timothy Nacarelli
Figure S4 shows that genetically knocking down NAMPT suppresses ovarian cancer stem-like cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bca1fdc61e4a71e5a6547e61946215
https://doi.org/10.1158/0008-5472.22425373
https://doi.org/10.1158/0008-5472.22425373