Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Timothy N. Holt"'
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Akademický článek
Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension
Autor: Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark, R. Dale Brown
Publikováno v: Frontiers in Physiology, Vol 12 (2021)
Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that targeting chr
Externí odkaz: https://doaj.org/article/387cb974a6c741868b4c75a56eda2db7
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2
Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model
Autor: R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R. Stenmark
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H804-H820
Using a large animal model and employing a comprehensive approach integrating hemodynamic, transcriptomic, proteomic, and immunohistochemical analyses, we examined the early (2 wk) effects of severe PH on the RV. We observed that RV remodeling during
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e426dd05eb030a8846d9667ad5f8d584
https://doi.org/10.1152/ajpheart.00614.2022
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6
Investigation of neonatal disorders in New World camelids and factors associated with death during and after hospitalization of affected crias
Autor: Stephanie L. Frank, Eileen S. Hackett, Robert J. Callan, Katharine M. Simpson, Timothy N. Holt, Brad B. Nelson
Publikováno v: Journal of the American Veterinary Medical Association. 258:892-898
OBJECTIVE To assess signalment, clinical findings, and treatments for New World camelids (NWCs) hospitalized for evaluation and treatment of neonatal disorders and investigate associations between these factors and death during and after hospitalizat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e81c9057d8470d365d5359be3d8b39
https://doi.org/10.2460/javma.258.8.892
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Plný text Recenzováno Digitální knihovna AV ČR
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