Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Timothy N Audam"'
Autor:
Sujith Dassanayaka, Kenneth R Brittian, Bethany W Long, Lauren A Higgins, James A Bradley, Timothy N Audam, Andrea Jurkovic, Anna M Gumpert, Linda T Harrison, István Hartyánszky, Péter Perge, Béla Merkely, Tamás Radovits, John A Hanover, Steven P Jones
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242250 (2020)
RationaleThe beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. T
Externí odkaz:
https://doaj.org/article/0bd4b5220506470fb0e879d5febfd118
Autor:
Sujith Dassanayaka, Yuting Zheng, Andrew A. Gibb, Timothy D. Cummins, Lindsey A. McNally, Kenneth R. Brittian, Ganapathy Jagatheesan, Timothy N. Audam, Bethany W. Long, Robert E. Brainard, Steven P. Jones, Bradford G. Hill
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 440-449 (2018)
Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde detoxification enzymes, including aldehyde dehydrogenase 2 (ALDH2). An emerging idea that cou
Externí odkaz:
https://doaj.org/article/26cadb1f9fa54a289fd9b0c378338d7a
Autor:
Timothy D. Cummins, Teresa Cassel, William L. Dean, Bradford G. Hill, Michael L. Merchant, Teresa W.-M. Fan, Yuting Zheng, Pawel Lorkiewicz, Timothy N. Audam, Kyle L Fulghum
Publikováno v:
Journal of molecular and cellular cardiology
Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the f
Autor:
Ernesto Pena Calderin, Jing-Juan Zheng, Nolan L. Boyd, Lindsey McNally, Timothy N. Audam, Pawel Lorkiewicz, Bradford G. Hill, Jason Hellmann
Publikováno v:
Molecular Metabolism. 66:101637
Physical activity has been shown to reduce the risk of CVD mortality in large-cohort longitudinal studies; however, the mechanisms underpinning the beneficial effects of exercise remain incompletely understood. Emerging data suggest that the risk red
Autor:
James Bradley, Sujith Dassanayaka, Yi Wei Zheng, Szilvia Herczeg, Caitlin M Howard, Bradford G. Hill, Matthew W. Frank, Lauren F Garrett, Tamás Radovits, Suzanne Jackowski, Miklós Pólos, Kenneth R. Brittian, Steven P. Jones, Shizuka Uchida, Timothy N. Audam, Béla Merkely, Kyle L Fulghum
Publikováno v:
Am J Physiol Heart Circ Physiol
Coenzyme A (CoA) is an essential cofactor required for intermediary metabolism. Perturbations in homeostasis of CoA have been implicated in various pathologies; however, whether CoA homeostasis is changed and the extent to which CoA levels contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d0fef2483bc01a7cdd55989c7737b2
https://europepmc.org/articles/PMC8794231/
https://europepmc.org/articles/PMC8794231/
Autor:
Andrew A. Gibb, Tariq R. Altamimi, Yuting Zheng, Timothy N. Audam, Siqi Liu, Steven P. Jones, Bradford G. Hill
Publikováno v:
Circulation Research. 127
Mitochondrial supercomplexes are prominent in mammalian tissues that have high energy demand. Nevertheless, the mechanisms that regulate supercomplex formation and abundance remain unclear. In this study, we examined how myocardial fuel preference re
Autor:
Yiru Guo, Yibing Nong, Steven P. Jones, Andrea Jurkovic, Xiaoping Zhu, Daniel W. Riggs, Marcin Wysoczynski, Tyler Weirick, Anna M. Gumpert, Alex Tomlin, Hong Li, Kenneth R. Brittian, Yi Wei Zheng, Shizuka Uchida, Bethany W. Long, Timothy N. Audam
Publikováno v:
Am J Physiol Heart Circ Physiol
Although cell therapy-mediated cardiac repair offers promise for treatment/management of heart failure, lack of fundamental understanding of how cell therapy works limits its translational potential. In particular, whether reparative cells from faili
Autor:
John A. Hanover, Linda T. Harrison, Timothy N. Audam, James Bradley, Sujith Dassanayaka, Anna M. Gumpert, Bethany W. Long, Béla Merkely, Steven P. Jones, Andrea Jurkovic, István Hartyánszky, Lauren A. Higgins, Péter Perge, Kenneth R. Brittian, Tamás Radovits
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242250 (2020)
PLoS ONE, Vol 15, Iss 11, p e0242250 (2020)
Rationale The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury.
Autor:
Andrea Jurkovic, Kenneth R. Brittian, Marcin Wysoczynski, Sujith Dassanayaka, Timothy N. Audam, Steven P. Jones, Bethany W. Long
Publikováno v:
Circulation Research. 125
Background: The extracellular matrix (ECM) provides structural and functional support for the myocardium, but myocardial infarction (MI) changes the composition of the ECM. One of the chief components of the ECM, hyaluronan (HA), is elevated after MI
Autor:
Mitali G. Chitre, Bethany W. Long, Linda T. Harrison, Lauren A. Higgins, Giuseppe Militello, Shizuka Uchida, Daniel W. Riggs, Anna M. Gumpert, Kenneth R. Brittian, Steven P. Jones, Timothy N. Audam, Andrea Jurkovic, Senthilkumar K. Muthusamy, Sujith Dassanayaka
Publikováno v:
Basic Res Cardiol
Several post-translational modifications figure prominently in ventricular remodeling. The beta-O-linkage of N-acetylglucosamine (O-GlcNAc) to proteins has emerged as an important signal in the cardiovascular system. Although there are limited insigh