Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity

Autor: Sameera Peraramelli, Qi Zhou, Qin Zhou, Bettina Wanko, Lei Zhao, Toshihiko Nishimura, Thomas H. Leung, Seiya Mizuno, Mamoru Ito, Timothy Myles, Thomas M. Stulnig, John Morser, Lawrence L.K. Leung

Publikováno v: J Thromb Haemost

BACKGROUND: Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α(4)β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a42cba05d55c5e1170a617db3b9660
https://pubmed.ncbi.nlm.nih.gov/35108449

Intravenous versus subcutaneous immunoglobulin – Authors' reply

Autor: Ivo N van Schaik, Orell Mielke, Arman Sabet, Koshy George, Leslie Roberts, Ross Carne, Stefan Blum, Robert Henderson, Philip Van Damme, Jelle Demeestere, Sandrine Larue, Catherine-Andree Pinard D'Amour, Vera Bril, Ari Breiner, Pavel Kunc, Martin Valis, Jana Sussova, Tomas Kalous, Radomir Talab, Michal Bednar, Toomas Toomsoo, Inna Rubanovits, Katrin Gross-Paju, Ulvi Sorro, Mika Saarela, Mari Auranen, Jean Pouget, Shahram Attarian, Gwendal Le Masson, Anne-Cécile Wielanek-Bachelet, Claude Desnuelle, Emilien Delmont, Pierre Clavelou, Dominique Aufauvre, Jens Schmidt, Jana Zschuentssch, Claudia Sommer, Daniela Kramer, Olaf Hoffmann, Carsten Goerlitz, Judith Haas, Marko Chatzopoulos, Min-Suk Yoon, Ralf Gold, Peter Berlit, Andrea Jaspert-Grehl, David Liebetanz, Anna Kutschenko, Martin Stangel, Corinna Trebst, Petra Baum, Florian Then Bergh, Juliane Klehmet, Andreas Meisel, Fabian Klostermann, Johanna Oechtering, Helmar Lehmann, Michael Schroeter, Tim Hagenacker, Daniel Mueller, Anne-Dorte Sperfeld, Florian Bethke, Hans-Peter Hartung, Vivian Drory, Avi Algom, David Yarnitsky, Beth Brianna Murinson, Antonio Di Muzio, Fausta Ciccocioppo, Sandro Sorbi, Sabrina Mata, Angelo Schenone, Marina Grandis, Giuseppe Lauria, Daniele Cazzato, Giovanni Antonini, Stefania Morino, Dario Cocito, Maurizio Zibetti, Takanori Yokota, Takuya Ohkubo, Takashi Kanda, Motoharu Kawai, Kenichi Kaida, Hiroyuki Onoue, Satoshi Kuwabara, Masahiro Mori, Masahiro Iijima, Ken Ohyama, Gen Sobue, Masayuki Baba, Masahiko Tomiyama, Kazutoshi Nishiyama, Tsugio Akutsu, Kazumasa Yokoyama, Kazuaki Kanai, Ivo N. van Schaik, Filip Eftimov, Nicolette. C. Notermans, Nora. A. Visser, Catharina Faber, Janneke. G.J. Hoeijmakers, Ingemar S.J. Merkies, Nan van Geloven, Konrad Rejdak, Urszula Chyrchel-Paszkiewicz, Carlos Casanovas Pons, María Antonia Alberti Aguiló, Josep Gamez, María Figueras, Celedonio Marquez Infante, Sonia Benitez Rivero, Michael Lunn, Jasper Morrow, David Gosal, Timothy Myles Lavin, Isaac Melamed, Alessandro Testori, Senda Ajroud-Driss, Daniela Menichella, Ericka Simpson, Eugene Chi-Ho Lai, Mazen Dimachkie, Richard J. Barohn, Said Beydoun, Harpreet Johl, Dale Lange, Alexander Shtilbans, Suraj Muley, Shafeeq Ladha, Miriam Freimer, John Kissel, Norman Latov, Russell Chin, Eroboghene Ubogu, Sandi Mumfrey, T. Hermanth P. Rao, Paul MacDonald, Khema Sharma, Ginna Gonzalez, Jeffrey Allen, David Walk, Lisa Hobson-Webb, Karissa Gable, Richard A. Lewis, David R. Cornblath, John-Phillip Lawo, Michaela Praus, Billie L. Durn

Publikováno v: Lancet neurology, 17(5), 393-394. Lancet Publishing Group

We thank Ravi Uniyal and colleagues for their comments on our results from the PATH trial1 on subcutaneous immunoglobulin (SCIg) for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (CIDP). They express concern about the rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bbab476f42fdc4ef954363ef718221
http://hdl.handle.net/11567/941843

Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis

Autor: Shadi Sharif, Mariko Nagashima, William H. Robinson, Lawrence L.K. Leung, Stuart B. Goodman, David M. Lee, John Morser, Timothy Myles, Elizabeth A. Price, Jason J. Song, Xiao-Yan Du

Publikováno v: Arthritis & Rheumatism. 60:2902-2912

Objective. Osteopontin (OPN) is a proinflammatory cytokine that plays an important role in the pathogenesis of rheumatoid arthritis (RA). OPN can be cleaved by thrombin, resulting in OPN-R and exposing the cryptic C-terminal 41 and 91 integrin–bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606860febad1f6f7d07905aaa66fba83
https://doi.org/10.1002/art.24814

Thrombin Hydrolysis of Human Osteopontin Is Dependent on Thrombin Anion-binding Exosites

Autor: Lawrence L.K. Leung, Timothy Myles

Publikováno v: Journal of Biological Chemistry. 283:17789-17796

The cytokine osteopontin (OPN) can be hydrolyzed by thrombin exposing a cryptic alpha(4)beta(1)/alpha(9)beta(1) integrin-binding motif (SVVYGLR), thereby acting as a potent cytokine for cells bearing these activated integrins. We show that purified m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32f5afce9ae63becc5059651bb665cb
https://doi.org/10.1074/jbc.m708629200

Molecular Mapping of the Thrombin-Heparin Cofactor II Complex

Autor: Yolanda M. Fortenberry, Lawrence L.K. Leung, Timothy Myles, Frank C. Church, Herbert C. Whinna, Holly R. Gentry

Publikováno v: Journal of Biological Chemistry. 279:43237-43244

We used 55 Ala-scanned recombinant thrombin molecules to define residues important for inhibition by the serine protease inhibitor (serpin) heparin cofactor II (HCII) in the absence and presence of glycosaminoglycans. We verified the importance of nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a824d71f54e224e11b769c0d49fcddf
https://doi.org/10.1074/jbc.m406716200