Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Autor: Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-14 (2022)

Abstract Background Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used.

Externí odkaz: https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Autor: Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Díez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Männistö, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters

Publikováno v: Nature Genetics 55 (2023) 1
Nat Genet
Nature Genetics, 55(1), 89-99
Fernandez-rozadilla, C, Timofeeva, M, Chen, Z, Law, P, Thomas, M, Schmit, S, Díez-obrero, V, Hsu, L, Fernandez-tajes, J, Palles, C, Sherwood, K, Briggs, S, Svinti, V, Donnelly, K, Farrington, S, Blackmur, J, Vaughan-shaw, P, Shu, X, Long, J, Cai, Q, Guo, X, Lu, Y, Broderick, P, Studd, J, Huyghe, J, Harrison, T, Conti, D, Dampier, C, Devall, M, Schumacher, F, Melas, M, Rennert, G, Obón-santacana, M, Martín-sánchez, V, Moratalla-navarro, F, Oh, J H, Kim, J, Jee, S H, Jung, K J, Kweon, S, Shin, M, Shin, A, Ahn, Y, Kim, D, Oze, I, Wen, W, Matsuo, K, Matsuda, K, Tanikawa, C, Ren, Z, Gao, Y, Jia, W, Hopper, J, Jenkins, M, Win, A K, Pai, R, Figueiredo, J, Haile, R, Gallinger, S, Woods, M, Newcomb, P, Duggan, D, Cheadle, J, Kaplan, R, Maughan, T, Kerr, R, Kerr, D, Kirac, I, Böhm, J, Mecklin, L, Jousilahti, P, Knekt, P, Aaltonen, L, Rissanen, H, Pukkala, E, Eriksson, J, Cajuso, T, Hänninen, U, Kondelin, J, Palin, K, Tanskanen, T, Renkonen-sinisalo, L, Zanke, B, Männistö, S, Albanes, D, Weinstein, S, Ruiz-narvaez, E, Palmer, J, Buchanan, D, Platz, E, Visvanathan, K, Ulrich, C, Siegel, E, Brezina, S, Gsur, A, Campbell, P, Chang-claude, J, Hoffmeister, M, Brenner, H, Slattery, M, Potter, J, Tsilidis, K, Schulze, M, Gunter, M, Murphy, N, Castells, A, Castellví-bel, S, Moreira, L, Arndt, V, Shcherbina, A, Stern, M, Pardamean, B, Bishop, T, Giles, G, Southey, M, Idos, G, Mcdonnell, K, Abu-ful, Z, Greenson, J, Shulman, K, Lejbkowicz, F, Offit, K, Su, Y, Steinfelder, R, Keku, T, Van Guelpen, B, Hudson, T, Hampel, H, Pearlman, R, Berndt, S, Hayes, R, Martinez, M E, Thomas, S, Corley, D, Pharoah, P, Larsson, S, Yen, Y, Lenz, H, White, E, Li, L, Doheny, K, Pugh, E, Shelford, T, Chan, A, Cruz-correa, M, Lindblom, A, Hunter, D, Joshi, A, Schafmayer, C, Scacheri, P, Kundaje, A, Nickerson, D, Schoen, R, Hampe, J, Stadler, Z, Vodicka, P, Vodickova, L, Vymetalkova, V, Papadopoulos, N, Edlund, C, Gauderman, W, Thomas, D, Shibata, D, Toland, A, Markowitz, S, Kim, A, Chanock, S, Van Duijnhoven, F, Feskens, E, Sakoda, L, Gago-dominguez, M, Wolk, A, Naccarati, A, Pardini, B, Fitzgerald, L, Lee, S C, Ogino, S, Bien, S, Kooperberg, C, Li, C, Lin, Y, Prentice, R, Qu, C, Bézieau, S, Tangen, C, Mardis, E, Yamaji, T, Sawada, N, Iwasaki, M, Haiman, C, Le Marchand, L, Wu, A, Qu, C, Mcneil, C, Coetzee, G, Hayward, C, Deary, I, Harris, S, Theodoratou, E, Reid, S, Walker, M, Ooi, L Y, Moreno, V, Casey, G, Gruber, S, Tomlinson, I, Zheng, W, Dunlop, M, Houlston, R & Peters, U 2022, ' Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries ', Nature Genetics . https://doi.org/10.1038/s41588-022-01222-9, https://doi.org/10.1038/s41588-022-01222-9

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and East Asian ancestry, identifying 205 independent risk associations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15df4717f873c1a13103310e40445c44
https://research.wur.nl/en/publications/deciphering-colorectal-cancer-genetics-through-multi-omic-analysi

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Autor: Ester Gil Vazquez, Nadia Nasreddin, Gabriel N. Valbuena, Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Holly R. Eggington, Ryan O. Schenck, Valérie M. Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R.M. Lannagan, Dustin J. Flanagan, Arafath K. Najumudeen, Sulochana Omwenga, Amy M.B. McCorry, Alistair Easton, Viktor H. Koelzer, James E. East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D. Campbell, Maurice B. Loughrey, Philip D. Dunne, Petros Tsantoulis, David J. Huels, Sabine Tejpar, Owen J. Sansom, Simon J. Leedham

Publikováno v: Vasquez, E G, Nasreddin, N, Valbuena, G N, Mulholland, E J, Belnoue-Davis, H L, Eggington, H R, Schenck, R O, Wouters, V M, Wirapati, P, Gilroy, K, Lannagan, T R M, Flanagan, D J, Najumudeen, A K, Omwenga, S, McCorry, A M B, Easton, A, Koelzer, V H, East, J E, Morton, D, Trusolino, L, Maughan, T, Loughrey, M B, Dunne, P D, Tsantoulis, P, Huels, D J, Tejpar, S, Sansom, O J & Leedham, S J 2022, ' Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia ', Cell Stem Cell, vol. 29, no. 8, pp. 1213-1228.e8 . https://doi.org/10.1016/j.stem.2022.07.008
Cell stem cell, 29(8), 1213-1228.e8. Cell Press

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterized by fetal transcriptional prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8ae6065d6af4d48e6bf14034d2918
https://pure.qub.ac.uk/en/publications/ebe1f6bb-dff1-49d2-b1ec-2dd3b998e338

Reply to A. Kurreck et al and M.S. Copur et al

Autor: Richard Adams, Richard Wilson, Louise Brown, Timothy Maughan

Publikováno v: Journal of Clinical Oncology. 40:1263-1264

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adb51d28132c3048819d8902820e1618
https://doi.org/10.1200/jco.21.02806

Evaluating many treatments and biomarkers in oncology: a new design.

Autor: Kaplan R; Richard Kaplan, Angela Crook, David Fisher, Louise Brown, and Mahesh Parmar, Medical Research Council Clinical Trials Unit, London; Timothy Maughan, University of Oxford, Oxford; and Richard Wilson, Queen's University Belfast, Belfast, United Kingdom., Maughan T, Crook A, Fisher D, Wilson R, Brown L, Parmar M

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2013 Dec 20; Vol. 31 (36), pp. 4562-8. Date of Electronic Publication: 2013 Nov 18.