Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Timothy Marlowe"'
Autor:
Anlin Feng, Yesenia Moreno Caro, Colin Gardner, Garrett Grischo, Ying Liang, Praveen D. Wickremasinghe, Michaela Polmann, Mrinalini Kala, Timothy Marlowe, Stephen M. Black, Kenneth S. Knox, Ting Wang
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical outcomes of IPF. Research has shown
Externí odkaz:
https://doaj.org/article/1671331977914ca4954a1cf8a6886a76
Autor:
Timothy Marlowe, Alexey Dementiev, Sheila Figel, Andrew Rivera, Michael Flavin, William Cance
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors that target
Externí odkaz:
https://doaj.org/article/cce4ecbff04543ec9096b2e32e90a127
Autor:
Carlos Alvarado, Erik Stahl, Karissa Koessel, Andrew Rivera, Brian R. Cherry, Surya V.S.R.K. Pulavarti, Thomas Szyperski, William Cance, Timothy Marlowe
Publikováno v:
Molecules, Vol 24, Iss 18, p 3352 (2019)
The Focal Adhesion Targeting (FAT) domain of Focal Adhesion Kinase (FAK) is a promising drug target since FAK is overexpressed in many malignancies and promotes cancer cell metastasis. The FAT domain serves as a scaffolding protein, and its interacti
Externí odkaz:
https://doaj.org/article/300dbdafadb04c4f8d2a207909d511c0
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74688 (2013)
Reduction or depletion of mitochondrial DNA (mtDNA) has been associated with cancer progression. Although imbalanced mtDNA content is known to occur in prostate cancer, differences in mtDNA content between African American (AA) and Caucasian American
Externí odkaz:
https://doaj.org/article/ca8185b42af349d2b92d982defd013a7
Publikováno v:
Chem Biol Drug Des
The N-terminal FERM domain of focal adhesion kinase (FAK) contributes to FAK scaffolding and interacts with HER2, an oncogene and receptor tyrosine kinase. The interaction between HER2 and FAK drives resistance to FAK-kinase domain inhibitors through
Publikováno v:
Valuing U.S. National Parks and Programs ISBN: 9781351055789
Valuing U.S. National Parks and Programs
Valuing U.S. National Parks and Programs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a726d2a0d19433f397581d571ef7f4
https://doi.org/10.4324/9781351055789-5
https://doi.org/10.4324/9781351055789-5
Autor:
Sheila Figel, Timothy Marlowe, Andrew Rivera, Alexey Dementiev, William G. Cance, Michael T. Flavin
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-9 (2019)
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-9 (2019)
Background Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors that target the kinas
Autor:
Andrew Rivera, Karissa Koessel, William G. Cance, Surya V.S.R.K. Pulavarti, Erik Stahl, Brian R. Cherry, Thomas Szyperski, Timothy Marlowe, Carlos Alvarado
Publikováno v:
Molecules
Volume 24
Issue 18
Molecules, Vol 24, Iss 18, p 3352 (2019)
Volume 24
Issue 18
Molecules, Vol 24, Iss 18, p 3352 (2019)
The Focal Adhesion Targeting (FAT) domain of Focal Adhesion Kinase (FAK) is a promising drug target since FAK is overexpressed in many malignancies and promotes cancer cell metastasis. The FAT domain serves as a scaffolding protein, and its interacti
Publikováno v:
Molecular cancer therapeutics. 15(12)
Focal adhesion kinase (FAK) is a major drug target in cancer and current inhibitors targeted to the ATP-binding pocket of the kinase domain have entered clinical trials. However, preliminary results have shown limited single-agent efficacy in patient
Autor:
Rahul Kumar, Dhyan Chandra, Sandeep Kumar, Timothy Marlowe, Nagendra Yadava, Péter Rapali, Ramesh Londonkar, Raghu Gogada, Andrea Schneider, Ajay K. Chaudhary, Leimin Sun, Neelu Yadav, Jordan O'Malley, Joseph R. Inigo, Pragya Srivastava
Publikováno v:
Free radical biologymedicine. 90
We have previously reported that neem limonoids (neem) induce multiple cancer cell death pathways. Here we dissect the underlying mechanisms of neem-induced apoptotic cell death in cancer. We observed that neem-induced caspase activation does not req