Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis?

Autor: Dhanasekaran Sivakumaran, Synne Jenum, Christian Ritz, Mario Vaz, Timothy Mark Doherty, Harleen M. S. Grewal

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Delays in diagnosis and treatment of pulmonary tuberculosis (TB) can lead to more severe disease and increased transmission. Contact investigation among household contacts (HHCs) of TB patients is crucial to ensure optimal outcomes. In the context of

Externí odkaz: https://doaj.org/article/d508a08d1307448886090651a5db598d

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

Autor: John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We therefore sought to i

Externí odkaz: https://doaj.org/article/e3c7dd1d08254a8dbb04f27f1e98da63

Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults

Autor: Mario Vaz, Timothy Mark Doherty, Harleen M. S. Grewal, Tom H. M. Ottenhoff, Sumithra Selvam, Dhanasekaran Sivakumaran, Christian Ritz, Synne Jenum, John Espen Gjøen

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 11. FRONTIERS MEDIA SA
Frontiers in Immunology, Vol 11 (2021)
Sivakumaran, D, Ritz, C, Gjøen, J E, Vaz, M, Selvam, S, Ottenhoff, T H M, Doherty, T M, Jenum, S & Grewal, H M S 2021, ' Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults ', Frontiers in Immunology, vol. 11, 626049 . https://doi.org/10.3389/fimmu.2020.626049

To achieve the ambitious targets for tuberculosis (TB) prevention, care, and control stated by the End TB Strategy, new health care strategies, diagnostic tools are warranted. Host-derived biosignatures are explored for their TB diagnostic potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aec9566075020394a120c7ec83a965
https://hdl.handle.net/11250/2991249

Identification of incipient tuberculosis in household contacts. The relevance of tuberculosis exposure scores and contact investigations

Autor: Gry Klouman Bekken, Christian Ritz, Sumithra Selvam, Jesuraj Nelson, Anneke C Hesseling, Timothy Mark Doherty, Harleen MS Grewal, Mario Vaz, Synne Jenum

Background The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient TB, recently defined by key stakeholders as an “asymptomatic, early pre-clinical disease during which pathology evol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::540211b3057456035cf68167b10e6368
https://doi.org/10.21203/rs.2.16912/v1

Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles

Autor: John Kenneth, Ruth Stavrum, Mario Vaz, Synne Jenum, Christian Ritz, Timothy Mark Doherty, S. Dhanasekaran, Harleen M. S. Grewal

Publikováno v: Genes & Immunity. 15:265-274

The tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-tube (QFTGIT) are adjunctive tests used in the diagnosis of pediatric tuberculosis (TB). Neither test can rule out TB; however, a positive test usually triggers preventive treatment in TB cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70610aae509d04958125b8a99fdf612b
https://doi.org/10.1038/gene.2014.13