Zobrazeno 1 - 10 of 150 pro vyhledávání: '"Timothy M. Stearns"'
1
Akademický článek
A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury
Autor: Ramani Soundararajan, Helena Hernández-Cuervo, Timothy M Stearns, Anthony J Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Background: Critically ill patients on supplemental oxygen therapy eventually develop acute lung injury (ALI). Reactive oxygen species (ROS) produced during ALI perturbs the mitochondrial dynamics resulting in cellular damage. Genetic deletion of the
Externí odkaz: https://doaj.org/article/60d6092c74c549c8962d337265289e32
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2
Akademický článek
A novel mouse model expressing human forms for complement receptors CR1 and CR2
Autor: Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Publikováno v: BMC Genetics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine fu
Externí odkaz: https://doaj.org/article/614e55b302c34685b237b64274f950f7
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3
Akademický článek
Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis
Autor: Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi
Publikováno v: Biomolecules, Vol 12, Iss 2, p 283 (2022)
Abnormalities in airway epithelia and lung parenchyma are found in Atp8b1 mutant mice, which develop pulmonary fibrosis after hyperoxic insult. Microarray and ingenuity pathway analysis (IPA) show numerous transcripts involved in ciliogenesis are dow
Externí odkaz: https://doaj.org/article/c543cc6e09624b9d88bffc5c6421d434
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4
Akademický článek
Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX)
Autor: Joan E. Malcolm, Timothy M. Stearns, Susan D. Airhart, Joel H. Graber, Carol J. Bult
Publikováno v: PeerJ, Vol 7, p e6586 (2019)
In this study, we investigated the impact of initial tumor volume, rate of tumor growth, cohort size, study duration, and data analysis method on chemotherapy treatment response classifications in patient-derived xenografts (PDXs). The analyses were
Externí odkaz: https://doaj.org/article/48caf2190af14f229f3b7d6f4a29e13d
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8
Supplementary Figure 6 from Notch1-Induced Brain Tumor Models the Sonic Hedgehog Subgroup of Human Medulloblastoma
Autor: Kyuson Yun, Jeong K. Yoon, Susan L. Ackerman, Roderick T. Bronson, Timothy M. Stearns, Michael D. Taylor, David J. Shih, Emily E. Miller, Yaochen Li, Sivaraman Natarajan
PDF file - 65K, Supplementary Figure 6. A schematic drawing of full length N1ICD in mouse, N1ICD allele analyzed in this study, and the ACTB-Notch1 allele previously published (Yang et al., 2004) and analyzed in Supplementary Figure 6.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d19da1cb4ea06fda60fd764a78e719
https://doi.org/10.1158/0008-5472.22398012.v1
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