Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Timothy M. Locke"'
Autor:
Timothy M. Locke, Rose Fields, Hayden Gizinski, George M. Otto, Melissa J.S. MacEwen, Domnita-Valeria Rusnac, Peixian He, David M. Shechner, Chris D. McGann, Matthew D. Berg, Judit Villen, Yasemin Sancak, Devin K. Schweppe
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114879- (2024)
Summary: Calcium ions play important roles in nearly every biological process, yet whole-proteome analysis of calcium effectors has been hindered by a lack of high-throughput, unbiased, and quantitative methods to identify protein-calcium engagement.
Externí odkaz:
https://doaj.org/article/83058aefa024485bafa97ed7f25ab95d
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Mitochondrial complex I deficiency is frequent in congenital, neurologic and cardiovascular disease. Here the authors demonstrate that Complex I stimulates the turnover of a mitochondrial calcium channel, which becomes stabilized during Complex I def
Externí odkaz:
https://doaj.org/article/c2ef9f77a9ef4d22aad9d8b4d27239a7
Autor:
Melissa J.S. MacEwen, Domnita-Valeria Rusnac, Henok Ermias, Timothy M. Locke, Hayden E. Gizinski, Joseph P. Dexter, Yasemin Sancak
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106146- (2023)
Summary: Activation of myosin light chain kinase (MLCK) by calcium ions (Ca2+) and calmodulin (CaM) plays an important role in numerous cellular functions including vascular smooth muscle contraction and cellular motility. Despite extensive biochemic
Externí odkaz:
https://doaj.org/article/dfa9997666004496bd94070810bacbc7
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/375509dbb57e4c128813f2aea63a1296
Autor:
Timothy M. Locke, Hirofumi Fujita, Avery Hunker, Shelby S. Johanson, Martin Darvas, Sascha du Lac, Larry S. Zweifel, Erik S. Carlson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are
Externí odkaz:
https://doaj.org/article/e412d00db9334e8fbe4a78c21cfc592e
Autor:
Melissa JS MacEwen, Domnita-Valeria Rusnac, Henok Ermias, Timothy M Locke, Hayden E Gizinski, Joseph P Dexter, Yasemin Sancak
Activation of myosin light-chain kinase (MLCK) by calcium ions (Ca2+) and calmodulin (CaM) plays an important role in numerous cellular functions including vascular smooth muscle contraction and cellular motility. Despite extensive biochemical analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e45606ed2d49b25f2900afb491867dcd
https://doi.org/10.1101/2022.06.08.495195
https://doi.org/10.1101/2022.06.08.495195
Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors
Autor:
Timothy M. Locke, Martin Darvas, Steven A. Thomas, Avery C. Hunker, Stefan G. Sandberg, Abigail G. Schindler, Larry S. Zweifel, Paul E. M. Phillips, Julianne M. Geller, Erik S. Carlson
Publikováno v:
J Neurosci
The cerebellum processes neural signals related to rewarding and aversive stimuli, suggesting that the cerebellum supports nonmotor functions in cognitive and emotional domains. Catecholamines are a class of neuromodulatory neurotransmitters well kno
Autor:
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Publikováno v:
Nature communications. 13(1)
Calcium entering mitochondria potently stimulates ATP synthesis. Increases in calcium preserve energy synthesis in cardiomyopathies caused by mitochondrial dysfunction, and occur due to enhanced activity of the mitochondrial calcium uniporter channel
Autor:
Avery C. Hunker, Timothy M. Locke, Stefan G. Sandberg, Shelby S. Johanson, Erik S. Carlson, Larry S. Zweifel, Paul E. M. Phillips
Publikováno v:
Biological Psychiatry. 85:S143-S144
Autor:
Timothy M, Locke, Marta E, Soden, Samara M, Miller, Avery, Hunker, Cerise, Knakal, Julia A, Licholai, Karn S, Dhillon, C Dirk, Keene, Larry S, Zweifel, Erik S, Carlson
Publikováno v:
Biological psychiatry. 84(6)
BACKGROUND: Studies in humans and non-human primates have identified a region of the dentate nucleus of the cerebellum (DCN), or lateral nucleus in rodents (LCN), activated during performance of cognitive tasks involving complex spatial and sequentia