Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Timothy M. Hughes"'
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease
Autor:
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, José Contador, Jordan E. Tanley, Per Selnes, Berglind Gísladóttir, Lene Pålhaugen, Mathilde Suhr Hemminghyth, Jonas Jarholm, Ragnhild Skogseth, Geir Bråthen, Gøril Grøndtvedt, Atle Bjørnerud, Sandra Tecelao, Knut Waterloo, Dag Aarsland, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Michael Turton, Agnes Hesthamar, Przemyslaw R. Kac, Johanna Nilsson, Jose Luchsinger, Kathleen M. Hayden, Peter Harrison, Albert Puig-Pijoan, Henrik Zetterberg, Timothy M. Hughes, Marc Suárez-Calvet, Thomas K. Karikari, Tormod Fladby, Kaj Blennow
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ patho
Externí odkaz:
https://doaj.org/article/b027901016fa4e8ba7386d92b8d8e45e
Autor:
Nada El Husseini, Christopher L. Schaich, Suzanne Craft, Stephen R. Rapp, Kathleen M. Hayden, Richey Sharrett, Mary Frances Cotch, Tien Y. Wong, Jose A. Luchsinger, Mark A. Espeland, Laura D. Baker, Alain G. Bertoni, Timothy M. Hughes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Retinal vessel calibers share anatomic and physiologic characteristics with the cerebral vasculature and can be visualized noninvasively. In light of the known microvascular contributions to brain health and cognitive function, we aimed to d
Externí odkaz:
https://doaj.org/article/6bc37cff2dbf4539929a234764bc934d
Autor:
Adrienne Tin, Alison E. Fohner, Qiong Yang, Jennifer A. Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V. Lindbohm, Michael R. Duggan, Osorio Meirelles, Sarah E. Harris, Valborg Gudmundsdottir, Adele M. Taylor, Albert Henry, Alexa S. Beiser, Ali Shojaie, Annabell Coors, Annette L. Fitzpatrick, Claudia Langenberg, Claudia L. Satizabal, Colleen M. Sitlani, Eleanor Wheeler, Elliot M. Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C. Bis, Julián Candia, Lori L. Jennings, Maik Pietzner, Mark Lathrop, Oscar L. Lopez, Paul Redmond, Robert E. Gerszten, Stephen S. Rich, Susan R. Heckbert, Thomas R. Austin, Timothy M. Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S. Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I. Rotter, Keenan A. Walker, Luigi Ferrucci, Mika Kivimäki, Monique M. B. Breteler, Simon R. Cox, Stephanie Debette, Thomas H. Mosley, Vilmundur G. Gudnason, Lenore J. Launer, Bruce M. Psaty, Sudha Seshadri, Myriam Fornage
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We
Externí odkaz:
https://doaj.org/article/8eb6e400abed4b8eba3c10d3a6a5024b
Autor:
Yvonne L. Michael, Araliya M. Senerat, Channa Buxbaum, Ugonwa Ezeanyagu, Timothy M. Hughes, Kathleen M. Hayden, Julia Langmuir, Lilah M. Besser, Brisa Sánchez, Jana A. Hirsch
Publikováno v:
Public Health Reviews, Vol 45 (2024)
Objective: Synthesize longitudinal research evaluating neighborhood environments and cognition to identify methodological approaches, findings, and gaps.Methods: Included studies evaluated associations between neighborhood and cognition longitudinall
Externí odkaz:
https://doaj.org/article/e8e42093478c4600b01a98da3dcf558c
Autor:
Xiaowei Hu, Jeongok G. Logan, Younghoon Kwon, Joao A. C. Lima, David R. Jacobs, Daniel Duprez, Lyndia Brumback, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Thomas W. Blackwell, George Papanicolaou, Gary F. Mitchell, Stephen S. Rich, Jerome I. Rotter, David J. Van Den Berg, Julio A. Chirinos, Timothy M. Hughes, Francine E. Garrett-Bakelman, Ani Manichaikul
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link
Externí odkaz:
https://doaj.org/article/2566eec7931e4736bf4aa961b170b4a1
Autor:
Kentaro Ejiri, Ning Ding, Esther Kim, Yasuyuki Honda, Miguel Cainzos‐Achirica, Hirofumi Tanaka, Candace M. Howard‐Claudio, Kenneth R. Butler, Timothy M. Hughes, Jeremy R. Van't Hof, Michelle L. Meyer, Michael J. Blaha, Kunihiro Matsushita
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)
Background Pulse wave velocity (PWV) is a noninvasive measure of arterial stiffness and predictor of cardiovascular disease. However, the association between PWV and vascular calcification across different vascular beds has not been fully investigate
Externí odkaz:
https://doaj.org/article/9ff199a66ea44fbe80a60cee758964f0
Autor:
Tanweer Rashid, Hangfan Liu, Jeffrey B. Ware, Karl Li, Jose Rafael Romero, Elyas Fadaee, Ilya M. Nasrallah, Saima Hilal, R. Nick Bryan, Timothy M. Hughes, Christos Davatzikos, Lenore Launer, Sudha Seshadri, Susan R. Heckbert, Mohamad Habes
Publikováno v:
Neuroimage: Reports, Vol 3, Iss 1, Pp 100162- (2023)
Deep learning has been demonstrated effective in many neuroimaging applications. However, in many scenarios, the number of imaging sequences capturing information related to small vessel disease lesions is insufficient to support data-driven techniqu
Externí odkaz:
https://doaj.org/article/6d7e694cb4a14c5598006d5df77dee0b
Autor:
Thomas R. Austin, Paul N. Jensen, Ilya M. Nasrallah, Mohamad Habes, Tanweer Rashid, Jeffrey B. Ware, Lin Yee Chen, Philip Greenland, Timothy M. Hughes, Wendy S. Post, Steven J. Shea, Karol E. Watson, Colleen M. Sitlani, James S. Floyd, Richard A. Kronmal, W. T. Longstreth, Alain G. Bertoni, Sanjiv J. Shah, R. Nick Bryan, Susan R. Heckbert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Background Atrial fibrillation (AF) is associated with increased stroke risk and accelerated cognitive decline, but the association of early manifestations of left atrial (LA) impairment with subclinical changes in brain structure is unclear. We inve
Externí odkaz:
https://doaj.org/article/6d9d10004760486ea3d51a53b3fa963b
Autor:
Donghoon Kim, Timothy M. Hughes, Megan E. Lipford, Suzanne Craft, Laura D. Baker, Samuel N. Lockhart, Christopher T. Whitlow, Stephanie E. Okonmah-Obazee, Christina E. Hugenschmidt, Matthew Bobinski, Youngkyoo Jung
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1072069d8d9a49dc9d45eee79f075ac7
Autor:
Thomas R. Austin, Ilya M. Nasrallah, Guray Erus, Lisa M. Desiderio, Lin Y. Chen, Philip Greenland, Barbara N. Harding, Timothy M. Hughes, Paul N. Jensen, WT Longstreth, Wendy S. Post, Steven J. Shea, Colleen M. Sitlani, Christos Davatzikos, Mohamad Habes, R. Nick Bryan, Susan R. Heckbert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background Cardiovascular risk factors are associated with cognitive decline and dementia. Magnetic resonance imaging provides sensitive measurement of brain morphology and vascular brain injury. However, associations of risk factors with brain magne
Externí odkaz:
https://doaj.org/article/ba9324f94e7443e8bf2bc7d9f821baec