Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Timothy M. Horton"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100263- (2021)
Summary: Targeted drug delivery to pancreatic islet β cells is an unmet clinical need. β cells possess a uniquely high Zn2+ concentration, and integrating Zn2+-binding activity into a small molecule can bias drug accumulation and activity toward β
Externí odkaz:
https://doaj.org/article/f25539b332de466ab1c0549af7dbe774
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005943 (2017)
Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case man
Externí odkaz:
https://doaj.org/article/43cd1dea555b4106b220ff964f8f9bb5
Publikováno v:
Cancer Research. 83:3674-3674
Background: Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults. Characterization of GBM heterogeneity has identified four molecular subtypes based on transcriptomic profile: classical, neural, proneural and mesenchymal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352e31e78ef080184bd90ba3fb94193f
https://doi.org/10.1158/1538-7445.am2023-3674
https://doi.org/10.1158/1538-7445.am2023-3674
Autor:
Vandana Sundaram, Christine H. Lee, Kaisha N. Benjamin, Teri A. Longacre, Kathleen Hornbacker, Pamela L. Kunz, Allison Zemek, Aidan Van Vleck, Timothy M. Horton, Justin P. Annes
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Neuroendocrine neoplasms (NENs) are rare epithelial tumors with heterogeneous and frequently unpredictable clinical behavior. Available biomarkers are insufficient to guide individual patient prognosis or therapy selection. Peptidylglycine α-amidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c6dbbab213b446983bf2d786569811
http://link.springer.com/article/10.1038/s41598-020-68071-6
http://link.springer.com/article/10.1038/s41598-020-68071-6
Autor:
Rayhan A Lal, Hannah P Moeller, Ella A Thomson, Timothy M Horton, Sooyeon Lee, Raquel Freeman, Priya Prahalad, Ada S Y Poon, Justin P Annes
Publikováno v:
Endocrinology
Pathogenic INS gene mutations are causative for mutant INS-gene-induced diabetes of youth (MIDY). We characterize a novel de novo heterozygous INS gene mutation (c.289A>C, p.T97P) that presented in an autoantibody-negative 5-month-old male infant wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e59c942b60860492cab556157be81e1
https://pubmed.ncbi.nlm.nih.gov/34888628
https://pubmed.ncbi.nlm.nih.gov/34888628
Autor:
Mark Smith, Justin P. Annes, Paul Allegretti, Benjamin Yeh, Matthew Caffet, Yassan Abdolazimi, Timothy M. Horton, Hannah P. Moeller, Guillermina Michel
Publikováno v:
Bioorg Med Chem
Small molecule stimulation of β-cell regeneration has emerged as a promising therapeutic strategy for diabetes. Although chemical inhibition of dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is sufficient to enhance β-cell r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c14bde7a6a312e8cc57343ff6fb1ca
https://pubmed.ncbi.nlm.nih.gov/31757680
https://pubmed.ncbi.nlm.nih.gov/31757680
Publikováno v:
Journal of Proteome Research.
Liquid chromatography mass spectrometry (LCMS) proteomic analyses have revealed that host proteins are often captured in extracellular virions. These proteins may play a role in viral replication or infectivity and can represent targets for broad-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49869bd0545eb9cfaa96fc22d844b1b
https://doi.org/10.1021/acs.jproteome.8b00204
https://doi.org/10.1021/acs.jproteome.8b00204
Autor:
Steven J. Berardinelli, Naotaka Tsutsumi, Jacob Piehler, Leon Su, Timothy M. Horton, K. Christopher Garcia, Nichole K. Escalante, Edgar G. Engleman, Kevin Jude, Robert S. Haltiwanger, Junel Sotolongo Bellón, Juan L. Mendoza
Publikováno v:
Nature. 567(7746)
The cytokine interferon-γ (IFNγ) is a central coordinator of innate and adaptive immunity, but its highly pleiotropic actions have diminished its prospects for use as an immunotherapeutic agent. Here, we took a structure-based approach to decouplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d49b7e4391c71ba11206a09513f7c8
https://pubmed.ncbi.nlm.nih.gov/31131497
https://pubmed.ncbi.nlm.nih.gov/31131497
Autor:
Hannah P. Moeller, Justin P. Annes, Mark Smith, Neali A Armstrong, Yassan Abdolazimi, Sooyeon Lee, Timothy M. Horton, Benjamin Yeh, David McCutcheon, Haixia Xu, Robert J. Nichols, Paul Allegretti, Aryaman Shalizi, Zhengshan Zhao
Pharmacologic expansion of endogenous β cells is a promising therapeutic strategy for diabetes. To elucidate the molecular pathways that control β-cell growth we screened ∼2400 bioactive compounds for rat β-cell replication-modulating activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d23618a08522a31d31e5fde9a0b579a
https://europepmc.org/articles/PMC6287593/
https://europepmc.org/articles/PMC6287593/
Autor:
Patrick R. Visperas, Christopher G. Wilson, Neel H. Shah, Diane J. Aum, Tiago Barros, Jonathan A. Winger, Michelle R. Arkin, Arthur Weiss, Qingrong Yan, Alyssa Tao, John Kuriyan, Timothy M. Horton
Publikováno v:
Biochemical Journal. 465:149-161
Zeta-chain Associated Protein of 70kDa (ZAP-70) and Spleen tyrosine kinase (Syk) are non-receptor tyrosine kinases that are essential for T-cell and B-cell antigen receptor signaling, respectively. They are recruited, via their tandem-SH2 domains, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb99aec6f254825282634d3020010b3
https://doi.org/10.1042/bj20140793
https://doi.org/10.1042/bj20140793