Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy M. Harper"'
Autor:
Mary Jane Cullen, Qian Xiang, Jeffrey A. Robl, Philip M. Sher, Brian J. Murphy, Keith J. Miller, Timothy M. Harper, Andrew Alt, Emily Luk, Sarah E. Malmstrom, Dean A. Wacker, Ginger Wu, Kimberly A. Foster, John M. Fevig, Joseph Carpenter, Robert L. Bertekap, Mary F. Grubb, Ying Wang, Karen A. Rossi, Gang Wu, Christian L. Morales, Jianxin Feng, Xiang Yang Ye, Anthony V. Azzara, Matthias Broekema
Publikováno v:
Journal of Medicinal Chemistry. 60:6166-6190
Agonism of the 5-HT2C receptor represents one of the most well-studied and clinically proven mechanisms for pharmacological weight reduction. Selectivity over the closely related 5-HT2A and 5-HT2B receptors is critical as their activation has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab408370d6568ec38a8faeab8daced5
https://doi.org/10.1021/acs.jmedchem.7b00385
https://doi.org/10.1021/acs.jmedchem.7b00385
Autor:
Dietmar A. Seiffert, Daniel L. Cheney, Swanee Jacutin-Porte, E. Scott Priestley, Anzhi Wei, Pancras C. Wong, Ruth R. Wexler, Ladziata Vladimir, Timothy M. Harper, Jiang Wen, Peter W. Glunz, Yan Zou, Xiaojun Zhang, Joseph M. Luettgen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5051-5057
Selective tissue factor-factor VIIa complex (TF-FVIIa) inhibitors are viewed as promising compounds for treating thrombotic disease. In this contribution, we describe multifaceted exploratory SAR studies of S1′-binding moieties within a macrocyclic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd6f1e78e0f20de0a2c6371e9c3db79
https://doi.org/10.1016/j.bmcl.2016.08.088
https://doi.org/10.1016/j.bmcl.2016.08.088
Autor:
Monique Phillips, Brandon Parkhurst, E. Scott Priestley, Pancras C. Wong, Ruth R. Wexler, Xiaojun Zhang, Peter W. Glunz, Nicholas R. Wurtz, Daniel L. Cheney, Yan Zou, Ladziata Vladimir, Swanee Jacutin-Porte, Jiang Wen, Joseph M. Luettgen, James A. Johnson, Dietmar A. Seiffert, Alan R. Rendina, Timothy M. Harper
Publikováno v:
Journal of Medicinal Chemistry. 59:7125-7137
Inhibitors of the tissue factor (TF)/factor VIIa complex (TF-FVIIa) are promising novel anticoagulants which show excellent efficacy and minimal bleeding in preclinical models. Starting with an aminoisoquinoline P1-based macrocyclic inhibitor, optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711b34dc28b27bae5c40db47c08ef65d
https://doi.org/10.1021/acs.jmedchem.6b00469
https://doi.org/10.1021/acs.jmedchem.6b00469
Autor:
Joseph, Carpenter, Ying, Wang, Gang, Wu, Jianxin, Feng, Xiang-Yang, Ye, Christian L, Morales, Matthias, Broekema, Karen A, Rossi, Keith J, Miller, Brian J, Murphy, Ginger, Wu, Sarah E, Malmstrom, Anthony V, Azzara, Philip M, Sher, John M, Fevig, Andrew, Alt, Robert L, Bertekap, Mary Jane, Cullen, Timothy M, Harper, Kimberly, Foster, Emily, Luk, Qian, Xiang, Mary F, Grubb, Jeffrey A, Robl, Dean A, Wacker
Publikováno v:
Journal of medicinal chemistry. 60(14)
Agonism of the 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4aad16c8dfe5c23e1f667fa571a60d5
https://pubmed.ncbi.nlm.nih.gov/28635286
https://pubmed.ncbi.nlm.nih.gov/28635286
Autor:
Pancras C. Wong, Ruth R. Wexler, Xiaojun Zhang, Joseph M. Luettgen, Alan R. Rendina, Anzhi Wei, Swanee Jacutin-Porte, Robert M. Knabb, Jiang Wen, Gang Luo, Timothy M. Harper, Xuhong Cheng, Peter W. Glunz, Yan Zou, Rushith Kumar Anumula, E. Scott Priestley, Daniel L. Cheney, Alexandra H. Nirschl, Nicholas R. Wurtz
Publikováno v:
ACS Medicinal Chemistry Letters. 5:188-192
Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77e6c8896472d4df12a5ae8e770c0f6
https://doi.org/10.1021/ml400453z
https://doi.org/10.1021/ml400453z
Autor:
Dietmar A. Seiffert, Bates J Alex, Pancras C. Wong, Rangaraj Narayanan, Joseph M. Luettgen, E. Scott Priestley, Alan R. Rendina, Jeremy M. Richter, Daniel L. Cheney, Timothy M. Harper, Anzhi Wei, Ruth R. Wexler
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f1ff4fd337f917536b6363b5574967
https://pubmed.ncbi.nlm.nih.gov/28105277
https://pubmed.ncbi.nlm.nih.gov/28105277
Spatial memory following shifts of gaze. I. Saccades to memorized world-fixed and gaze-fixed targets
Publikováno v:
Journal of neurophysiology. 89(5)
During a shift of gaze, an object can move along with gaze or stay fixed in the world. To examine the effect of an object's reference frame on spatial working memory, we trained monkeys to memorize locations of visual stimuli as either fixed in the w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce15f94acfabf3a32c77f7b391544b5
https://pubmed.ncbi.nlm.nih.gov/12740406
https://pubmed.ncbi.nlm.nih.gov/12740406