Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Timothy M. Gregg"'
Publikováno v:
Journal of Chemical Education. 98:1732-1735
Aldol chemistry is highlighted in many introductory organic chemistry laboratory experiments because it provides synthesis, mechanism, and experimental challenges for students. In the experiment described here, students synthesize dibenzalacetone der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1c408b82a44a579c1c13cba2313fed
https://doi.org/10.1021/acs.jchemed.0c00448
https://doi.org/10.1021/acs.jchemed.0c00448
Publikováno v:
Biophysical Journal. 104(3):565-574
Agonists, including the neurotransmitter acetylcholine (ACh), bind at two sites in the neuromuscular ACh receptor channel (AChR) to promote a reversible, global change in protein conformation that regulates the flow of ions across the muscle cell mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd7175f1c14df51a866fddfceeeac29
Publikováno v:
Proceedings of the National Academy of Sciences. 108:4328-4333
Allosteric proteins use energy derived from ligand binding to promote a global change in conformation. The “gating” equilibrium constant of acetylcholine receptor-channels (AChRs) is influenced by ligands, mutations, and membrane voltage. We engi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a78e67f5330bb874cfa1bb9a3df1f90
https://doi.org/10.1073/pnas.1016617108
https://doi.org/10.1073/pnas.1016617108
Publikováno v:
Tetrahedron Letters. 51:6429-6432
Rates of cyclopropanation for mono- and disubstituted allenes have been measured relative to standard substrates in reaction with aryldiazoacetate esters catalyzed by Rh2(S-DOSP)4. Phenylallene derivatives exhibited a linear correlation of rate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d21a5774fb8aa38798285549771758
https://doi.org/10.1016/j.tetlet.2010.09.143
https://doi.org/10.1016/j.tetlet.2010.09.143
Publikováno v:
Journal of the American Chemical Society. 125:15902-15911
The mechanism of the dirhodium tetracarboxylate catalyzed cyclopropanation of alkenes with both unsubstituted diazoacetates and vinyl- and phenyldiazoacetates was studied by a combination of (13)C kinetic isotope effects and density functional theory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dbe3c3457d2f650e43a05248eeac3c
https://doi.org/10.1021/ja036025q
https://doi.org/10.1021/ja036025q
Publikováno v:
Psychopharmacology. 167:386-392
"Agonist" therapy for drug addiction proposes that a long acting analog, with similar properties to the abused substance might serve as a useful therapeutic agent. HD-23 is a very long acting tropane analog that displays a neurochemical profile simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf7262438bbbe2a3b0c637bd3d51ad46
https://doi.org/10.1007/s00213-003-1424-z
https://doi.org/10.1007/s00213-003-1424-z
Publikováno v:
Organic Letters. 11:4434-4436
Reaction of monosubstituted allenes with aryldiazoacetate esters under dirhodium tetracarboxylate catalysis led to alkylidene cyclopropane products in 80-90% ee. Monosubstituted alkyl- and arylallene substrates gave 60-75% yield under standard condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d58ae6eca196ee57c6b8940a7b1dc8
https://doi.org/10.1021/ol9017968
https://doi.org/10.1021/ol9017968
Publikováno v:
The Journal of Organic Chemistry. 62:3715-3721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccbf9c5846b3ee3d4010dbc0387bf779
https://doi.org/10.1021/jo962215q
https://doi.org/10.1021/jo962215q
Autor:
Jeremy P. Olson, Changming Qin, Huw M. L. Davies, Kathryn M. Chepiga, Timothy M. Gregg, Joshua S. Alford, Spandan Chennamadhavuni
Publikováno v:
Tetrahedron. 69(27-28)
Catalytic enantioselective methods for the generation of cyclopropanes have been of long standing pharmaceutical interest. Chiral dirhodium(II) catalysts prove to be an effective means for the generation of diverse cyclopropane libraries. Rh2(R-DOSP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2f058b0d6c028a500e28181a29bfd0
https://pubmed.ncbi.nlm.nih.gov/24273349
https://pubmed.ncbi.nlm.nih.gov/24273349
Publikováno v:
Journal of the American Chemical Society. 135(45)
Reaction kinetics and mechanistic studies for ethylene-internal alkyne metathesis promoted by the phosphine-free initiator Ru1 (Piers's catalyst) is described. The kinetic order of reactants and catalyst was determined. The effect of ethylene was stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5212618bb1c8e9cf0de4dd6982b6e918
https://pubmed.ncbi.nlm.nih.gov/24187985
https://pubmed.ncbi.nlm.nih.gov/24187985