Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Timothy M. Crowder"'
Autor:
William M. Abraham, Dale J. Christensen, Juan R. Sabater, David W. Scott, Matthew P. Walker, Bryant Wu, Timothy J. Stuhlmiller, Juliana I. Sesma, Robert Tarran, Timothy M. Crowder
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:734-744
Rationale: Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f2e08f65d7323841ff070db75eccca
https://doi.org/10.1164/rccm.201612-2445oc
https://doi.org/10.1164/rccm.201612-2445oc
Autor:
Phillip Barley, Timothy M. Crowder, Dale J. Christensen, Matt Cowlen, Matthew P. Walker, Mutsumi Miyamoto
Publikováno v:
Inhalation Toxicology. 29:356-365
ENaC inhibition has long been an attractive therapeutic target for the treatment of cystic fibrosis. However, previous attempts at developing ENaC inhibitors have been unsuccessful due to complications arising from systemic circulation of the compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5701cd434eeb03a20c4746d952532913
https://doi.org/10.1080/08958378.2017.1366602
https://doi.org/10.1080/08958378.2017.1366602
Autor:
Timothy M. Crowder, Christie Hudson, Paulina Farias, Peter Couroux, Robert Tarran, K. Griffin, Leena Rizvi, Elizabeth Tullis
Publikováno v:
Pulmonary pharmacologytherapeutics. 58
Background ENaC inhibition has been investigated as a CF treatment; however, small molecule inhibitors of ENaC lack efficacy and/or have shown dose-limiting hyperkalemia . SPX-101 is a novel, investigational small peptide (SPLUNC1 mimetic) that regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab15a41f6fc2bffcde8f5f9409ad325
https://pubmed.ncbi.nlm.nih.gov/31302339
https://pubmed.ncbi.nlm.nih.gov/31302339
Autor:
Timothy M. Crowder
Publikováno v:
Powder Technology. 173:217-223
A proof of concept prototype has been constructed to test the capabilities of using vibration frequencies determined from rotating drum powder flow characterization to reproducibly fill small unit doses of pharmaceutical powders. A lactose excipient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df381b92c278f668fe322e23ab79277
https://doi.org/10.1016/j.powtec.2006.12.023
https://doi.org/10.1016/j.powtec.2006.12.023
Autor:
Matthew S. Ferriter, Juan Huang, C. Robin Hwang, Robert J. Garmise, Vincent J. Sullivan, Anthony J. Hickey, John A. Mikszta, Kevin D. Mar, Timothy M. Crowder
Publikováno v:
AAPS PharmSciTech. 7:E131-E137
The purpose of this research was to prepare a dry powder vaccine formulation containing whole inactivated influenza virus (VIIV) and a mucoadhesive compound suitable for nasal delivery. Powders containing WIIV and either lactose or trehalose were pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8726162b0f0ec263f98cef01e30f720e
https://doi.org/10.1208/pt070119
https://doi.org/10.1208/pt070119
Autor:
Vincent J. Sullivan, C. Robin Hwang, Anthony J. Hickey, Juan Huang, Robert J. Garmise, John A. Mikszta, Kevin D. Mar, Timothy M. Crowder
Publikováno v:
Vaccine. 23:794-801
Intranasal (i.n.) vaccination represents an attractive non-invasive alternative to needle-based injection and provides superior protection at mucosal surfaces. However, new formulations are needed to improve efficacy and reduce the refrigerated stora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e85eeb12f4c488812e52a40da8bbe33
https://doi.org/10.1016/j.vaccine.2004.06.049
https://doi.org/10.1016/j.vaccine.2004.06.049
Publikováno v:
Pharmaceutical Research. 19:239-245
Key factors that contribute to the aerodynamic properties of aerosol particles are found in Stokes' law. These factors may be monitored or controlled to optimize drug delivery to the lungs. Predictions of the aerodynamic behavior of therapeutic aeros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3bf8a291d56d4cb74a95422d29832b5
https://doi.org/10.1023/a:1014426530935
https://doi.org/10.1023/a:1014426530935
Publikováno v:
Journal of Cystic Fibrosis. 16:S37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::820e5f2b8cdf6505e185b82323ebf3bb
https://doi.org/10.1016/s1569-1993(17)30279-5
https://doi.org/10.1016/s1569-1993(17)30279-5
Publikováno v:
Particle & Particle Systems Characterization. 16:191-196
Previous studies of the flow of granular materials in a rotating drum have described the observed time sequences of angle of repose or time to avalanche. The time between avalanches approach has been incorporated into a commercially available powder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05523263095a193035a008a1527b6b5a
https://doi.org/10.1002/(sici)1521-4117(199908)16:4<191::aid-ppsc191>3.0.co
https://doi.org/10.1002/(sici)1521-4117(199908)16:4<191::aid-ppsc191>3.0.co
Autor:
R. Fellner, J. Neill, J. Hairr, D.J. Christensen, Robert Tarran, S. Terryah, Timothy M. Crowder
Publikováno v:
Journal of Cystic Fibrosis. 15:S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73a0dbb8cf3875842b950dedb0880d1
https://doi.org/10.1016/s1569-1993(16)30072-8
https://doi.org/10.1016/s1569-1993(16)30072-8