Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Timothy M. Braden"'
Autor:
Han Xia, Stephen R. Groskreutz, Michael O. Frederick, Michael E. Kopach, Nessa Mullane, Jeffrey T. Lampert, Kevin D. Seibert, Mark A. Strege, Neil J. Kallman, Bradley M. Campbell, Sergey V. Tsukanov, Frank L. Torres Torres, Ashley A. Humenik, Gordon R. Lambertus, Nil Tandogan, Nicholas D. Klitzing, Carmel Condon, Shujauddin M. Changi, Joel R. Calvin, Jennifer McClary Groh, Timothy M. Braden, Marie E. O’Mahony, Juliana Kretsinger, Rachel N. Richey, Stephanie R. Coffin, Laura M. Maguire, Richard D. Spencer, Raymond A. Boyse, Zachary D. Harms, John D. Murphy, Humphrey A. Moynihan, Olivia Gowran
Publikováno v:
Organic Process Research & Development. 25:1628-1636
Autor:
Richard D. Miller, Kevin P. Cole, Timothy M. Braden, Todd D. Maloney, Bradley M. Campbell, Moussa Boukerche, Christopher K. Lippelt, Brandon J. Reizman, David Mitchell, Derek R. Starkey, Richard F. Cope, Sam Tadayon, Xin Zhang, Ping Huang, Mindy B. Forst, Michael E. Laurila, Molly Hess, Jonas Y. Buser, Jing Chen, Martin Kwok, Baoquan Sun, Martin D. Johnson, Justin L. Burt, Carla V. Luciani
Publikováno v:
Organic Process Research & Development. 23:870-881
Technology transfer of a small volume continuous (SVC) process and Current Good Manufacturing Practices (cGMP) manufacturing of merestinib are described. A hybrid batch-SVC campaign was completed at a contract manufacturing organization under cGMP. T
Autor:
Mindy B. Forst, Edward W. Conder, Brandon J. Reizman, Timothy M. Braden, Justin L. Burt, Christopher S. Polster, Molly Hess, Kevin P. Cole, Bradley M. Campbell, David Mitchell, Richard F. Cope, Michael E. Laurila, Moussa Boukerche, Martin D. Johnson, Aurpon W. Mitra, Michael R. Heller, Richard D. Miller, Jennifer McClary Groh, Joseph L. Phillips, John R. Howell, Todd D. Maloney
Publikováno v:
Organic Process Research & Development. 23:858-869
Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic candidate merestinib is described. Continuous processing was enabled following the identification a
Autor:
Timothy M. Braden, Wei-Ming Sun, Bradley M. Campbell, Gordon R. Lambertus, Richard D. Spencer, Jennifer McClary Groh, Todd D. Maloney, Martin D. Johnson, Luke P. Webster, Paul Milenbaugh
Publikováno v:
Organic Process Research & Development. 23:189-210
Continued emphasis in the pharmaceutical industry toward development of hybrid and continuous processes has led to a resurgence in process analytical technologies. The need to consistently and rapidly monitor the quality of material being made from t
Autor:
Richard D. Spencer, Scott A. May, Timothy M. Braden, Martin D. Johnson, Jennifer McClary Groh
Publikováno v:
Continuous Pharmaceutical Processing ISBN: 9783030415235
Intermittent flow enables slurry flow out of continuous stirred tank crystallizers without solids plugging or clogging. It enables semi-continuous filtration, washing, and re-dissolving downstream from continuous crystallization. It allows solvent ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8bd7d60736ea9106ae24a0534789ebe
https://doi.org/10.1007/978-3-030-41524-2_4
https://doi.org/10.1007/978-3-030-41524-2_4
Autor:
Martin D. Johnson, Vaidyaraman Shankarraman, Luke P. Webster, Scott A. May, Jennifer McClary Groh, Richard D. Spencer, Timothy M. Braden, Christopher S. Polster, Carla V. Luciani
Publikováno v:
Continuous Pharmaceutical Processing ISBN: 9783030415235
Axial dispersion and residence time distribution (RTD) have significant process implications in the design of continuous processes. Low dispersion is better for minimizing time for complete reaction and minimizing deviation boundaries. High dispersio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6f9279d7888fe2e94d049e660133f8
https://doi.org/10.1007/978-3-030-41524-2_3
https://doi.org/10.1007/978-3-030-41524-2_3
Autor:
Vaidyaraman Shankarraman, Michael E. Kopach, Kevin P. Cole, Jennifer McClary Groh, Timothy M. Braden, Timothy D. White, Martin D. Johnson, Luke P. Webster, Scott A. May
Publikováno v:
Continuous Pharmaceutical Processing ISBN: 9783030415235
A variety of high-pressure and low-pressure plug flow reactors (PFRs) are described in this chapter with manufacturing examples for each. Coiled tube PFRs and vertical pipes-in-series PFRs were used for two-phase gas–liquid reactions. A pulsating f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93570a713fdf17e072cf8b26795adaeb
https://doi.org/10.1007/978-3-030-41524-2_2
https://doi.org/10.1007/978-3-030-41524-2_2
Autor:
Ayman Allian, Timothy M. Braden, Suzanne M. Opalka, J. Christopher McWilliams, Michel Journet, Scott A. May
Publikováno v:
Organic Process Research & Development. 22:1143-1166
This manuscript provides the results of an in-depth survey assessment of the capabilities, experience, and perspectives on continuous processing in the pharmaceutical sector, with respondents from both pharmaceutical companies and Contract Manufactur
Autor:
Richard D. Spencer, Michael E. Kopach, Martin D. Johnson, John P. Schafer, Michael R. Heller, Jennifer McClary Groh, Jonathan J. Adler, Timothy M. Braden, Jeffrey Lewis
Publikováno v:
Organic Process Research & Development. 21:317-326
A flow Barbier process was developed to produce a key intermediate in the edivoxetine·HCl registered sequence. The control strategy was developed based on a critical understanding of integrated parameters and design space requirements for a continuo
Autor:
Scott A. May, Jennifer McClary Groh, Michael E. Kopach, Timothy M. Braden, Martin D. Johnson, Jeremy M. Merritt, Vaidyaraman Shankarraman
Publikováno v:
Chemical Engineering in the Pharmaceutical Industry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a50fa8725cae8a7d816b86b924319d
https://doi.org/10.1002/9781119600800.ch16
https://doi.org/10.1002/9781119600800.ch16