Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.

Autor: Leora I Horwitz, Tanayott Thaweethai, Shari B Brosnahan, Mine S Cicek, Megan L Fitzgerald, Jason D Goldman, Rachel Hess, S L Hodder, Vanessa L Jacoby, Michael R Jordan, Jerry A Krishnan, Adeyinka O Laiyemo, Torri D Metz, Lauren Nichols, Rachel E Patzer, Anisha Sekar, Nora G Singer, Lauren E Stiles, Barbara S Taylor, Shifa Ahmed, Heather A Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C Bind, Lora J Black, Andra L Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W Charney, Benjamin K Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B Chibnik, Dominic C Chow, Helen Y Chu, Rebecca G Clifton, Shelby Collins, Maged M Costantine, Sushma K Cribbs, Steven G Deeks, John D Dickinson, Sarah E Donohue, Matthew S Durstenfeld, Ivette F Emery, Kristine M Erlandson, Julio C Facelli, Rachael Farah-Abraham, Aloke V Finn, Melinda S Fischer, Valerie J Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J Gallagher, Jennifer C Gander, Maria Laura Gennaro, Kelly S Gibson, Minjoung Go, Steven N Goodman, Joey P Granger, Frank L Greenway, John W Hafner, Jenny E Han, Michelle S Harkins, Kristine S P Hauser, James R Heath, Carla R Hernandez, On Ho, Matthew K Hoffman, Susan E Hoover, Carol R Horowitz, Harvey Hsu, Priscilla Y Hsue, Brenna L Hughes, Prasanna Jagannathan, Judith A James, Janice John, Sarah Jolley, S E Judd, Joy J Juskowich, Diane G Kanjilal, Elizabeth W Karlson, Stuart D Katz, J Daniel Kelly, Sara W Kelly, Arthur Y Kim, John P Kirwan, Kenneth S Knox, Andre Kumar, Michelle F Lamendola-Essel, Margaret Lanca, Joyce K Lee-Lannotti, R Craig Lefebvre, Bruce D Levy, Janet Y Lin, Brian P Logarbo, Jennifer K Logue, Michele T Longo, Carlos A Luciano, Karen Lutrick, Shahdi K Malakooti, Gail Mallett, Gabrielle Maranga, Jai G Marathe, Vincent C Marconi, Gailen D Marshall, Christopher F Martin, Jeffrey N Martin, Heidi T May, Grace A McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M Mullington, Girish N Nadkarni, Erica R Nahin, Robert B Neuman, Lisa T Newman, Amber Nguyen, Janko Z Nikolich, Igho Ofotokun, Princess U Ogbogu, Anna Palatnik, Kristy T S Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F Patterson, Ann Pearman, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, J Zachary Porterfield, John G Quigley, Davin K Quinn, Hengameh Raissy, Candida J Rebello, Uma M Reddy, Rebecca Reece, Harrison T Reeder, Franz P Rischard, Johana M Rosas, Clifford J Rosen, Nadine G Rouphael, Dwight J Rouse, Adam M Ruff, Christina Saint Jean, Grecio J Sandoval, Jorge L Santana, Shannon M Schlater, Frank C Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D Sesso, Dimpy P Shah, Eyal Shemesh, Zaki A Sherif, Daniel J Shinnick, Hyagriv N Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S Suthar, Larissa J Teunis, John M Thorp, Amberly Ticotsky, Alan T N Tita, Robin Tragus, Katherine R Tuttle, Alfredo E Urdaneta, P J Utz, Timothy M VanWagoner, Andrew Vasey, Suzanne D Vernon, Crystal Vidal, Tiffany Walker, Honorine D Ward, David E Warren, Ryan M Weeks, Steven J Weiner, Jordan C Weyer, Jennifer L Wheeler, Sidney W Whiteheart, Zanthia Wiley, Natasha J Williams, Juan P Wisnivesky, John C Wood, Lynn M Yee, Natalie M Young, Sokratis N Zisis, Andrea S Foulkes

Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0286297 (2023)

ImportanceSARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, tr

Externí odkaz: https://doaj.org/article/c631b9a817d842aa8407fbc8f59463ab

Antecedent Metabolic Health and Metformin (ANTHEM) Aging Study: Rationale and Study Design for a Randomized Controlled Trial

Autor: Santosh Kumari, Matthew T Bubak, Hayden M Schoenberg, Arik Davidyan, Christian J Elliehausen, Katrin G Kuhn, Timothy M VanWagoner, Rowan Karaman, Robert Hal Scofield, Benjamin F Miller, Adam R Konopka

Publikováno v: J Gerontol A Biol Sci Med Sci

The antidiabetic medication metformin has been proposed to be the first drug tested to target aging and extend healthspan in humans. While there is extensive epidemiological support for the health benefits of metformin in patient populations, it is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdfecfc21b6b62c289bb82ec37b8e84
https://doi.org/10.1093/gerona/glab358

Best Practices for Conducting Clinical Trials With Indigenous Children in the United States

Autor: Jessica N. Snowden, May Okihiro, Lee A. Pyles, Denise A. Dillard, Sarah Adeky, Judith L. Ross, John C. Carlson, Lancer Stephens, Johnnye L. Lewis, David Easa, Matthew Hirschfeld, Niki Graham, Timothy M. VanWagoner, Edgardo G. Szyld, Russell J. McCulloh, Erin O. Semmens, Paul M. Darden, Rosalyn J. Singleton, Paul Smith, Jennifer L. Shaw, Sara E. Watson

Publikováno v: Am J Public Health

We provide guidance for conducting clinical trials with Indigenous children in the United States. We drew on extant literature and our experience to describe 3 best practices for the ethical and effective conduct of clinical trials with Indigenous ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc526cab323a2171bb0183d8bfab2de4
https://europepmc.org/articles/PMC8494399/

The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant

Autor: Lauren O. Bakaletz, Daniel J. Morton, Terrence L. Stull, Thomas W. Seale, Timothy M. VanWagoner, Ann Smith, Paul W. Whitby, Joseph A. Jurcisek

Publikováno v: International Journal of Medical Microbiology. 299:479-488

Haemophilus influenzae has an absolute growth requirement for heme and the heme-binding lipoprotein (HbpA) and has been implicated in the utilization of this essential nutrient. We constructed an insertional mutation of hbpA in a type b and a nontype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3dba9f6ef677c5bb567e73c08902d6
https://doi.org/10.1016/j.ijmm.2009.03.004

The haem–haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae

Autor: Larissa L. Madore, Timothy M. VanWagoner, Terrence L. Stull, Daniel J. Morton, Paul W. Whitby, Thomas W. Seale

Publikováno v: Microbiology. 153:215-224

Haemophilus influenzae has an absolute growth requirement for a porphyrin source, which can be supplied in vitro by haem, haemoglobin, or the haemoglobin-haptoglobin, haem-haemopexin and haem-albumin complexes. Utilization of the haem-haemopexin comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0b3b43b06f80c3615776410017e822
https://doi.org/10.1099/mic.0.2006/000190-0