Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Timothy M Murphy"'
Autor:
Leslie W Tari, Xiaoming Li, Michael Trzoss, Daniel C Bensen, Zhiyong Chen, Thanh Lam, Junhu Zhang, Suk Joong Lee, Grayson Hough, Doug Phillipson, Suzanne Akers-Rodriguez, Mark L Cunningham, Bryan P Kwan, Kirk J Nelson, Amanda Castellano, Jeff B Locke, Vickie Brown-Driver, Timothy M Murphy, Voon S Ong, Chris M Pillar, Dean L Shinabarger, Jay Nix, Felice C Lightstone, Sergio E Wong, Toan B Nguyen, Karen J Shaw, John Finn
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84409 (2013)
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA t
Externí odkaz:
https://doaj.org/article/61b9ed4eb647499192d901bd0163432e
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 38:409-412
The in vitro and in vivo antimicrobial activities of dihydrofolate reductase (DHFR) inhibitors are inhibited in the presence of free thymidine in the growth milieu and in rodent efficacy models. However, for thymidine kinase (TK) deficient mutant bac
Autor:
Daniel P. Ahern, Joseph S. Butler, Alexander R. Vaccaro, Greg D. Schroeder, Timothy M Murphy, Gillian P. Johnson, Denys Gibbons
Publikováno v:
Clinical spine surgery. 32(10)
Lower back pain is a commonly reported symptom during pregnancy. However, herniated lumbar disk disease is an uncommon cause for such pain. Cauda equina syndrome (CES) during pregnancy is a rare clinical scenario. This review highlights the epidemiol
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:2567-2571
Eravacycline is a novel broad-spectrum fluorocycline antibiotic being developed for a wide range of serious infections. Eravacycline was efficacious in mouse septicemia models, demonstrating 50% protective dose (PD 50 ) values of ≤1 mg/kg of body w
Autor:
Trudy H. Grossman, Corey Fyfe, William O’Brien, Meredith Hackel, Mary Beth Minyard, Ken B. Waites, Jacques Dubois, Timothy M. Murphy, Andrew M. Slee, William J. Weiss, Joyce A. Sutcliffe, Mariana Castanheira
Publikováno v:
mSphere
mSphere, Vol 2, Iss 1 (2017)
mSphere, Vol 2, Iss 1, p e00004-17 (2017)
mSphere, Vol 2, Iss 1 (2017)
mSphere, Vol 2, Iss 1, p e00004-17 (2017)
Rising resistance rates for macrolides, fluoroquinolones, and β-lactams in the most common pathogens associated with community-acquired bacterial pneumonia (CABP) are of concern, especially for cases of moderate to severe infections in vulnerable po
Autor:
Mark L. Cunningham, Doug Phillipson, Bryan P. Kwan, John T. Finn, Kirk J. Nelson, Sergio E. Wong, Michael Trzoss, Jeff B. Locke, Jay C. Nix, Vickie Brown-Driver, Felice C. Lightstone, Zhiyong Chen, Toan B. Nguyen, Karen J. Shaw, Suzanne Akers-Rodriguez, Xiaoming Li, Suk Joong Lee, Amanda Castellano, Dean L. Shinabarger, Timothy M. Murphy, Junhu Zhang, Leslie W. Tari, Chris M. Pillar, Voon Ong, Grayson Hough, Thanh Lam, Daniel C. Bensen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84409 (2013)
PLoS ONE
PLoS ONE
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA t
Autor:
Timothy M. Murphy, Steven J. Projan, Patricia A. Bradford, William J. Weiss, Peter Petersen, Phaik-Eng Sum
Publikováno v:
Antimicrobial agents and chemotherapy. 46(8)
Tigecycline (GAR-936) and daptomycin are potent antibacterial compounds in advanced stages of clinical trials. These novel agents target multiply resistant pathogenic bacteria. Daptomycin is principally active against gram-positive bacteria, while ti
Publikováno v:
Antimicrobial agents and chemotherapy. 44(11)
Endocarditis has many underlying causes, including complications from intravenous drug use, prosthetic valves, and nosocomial bacteremia, leading to extended hospital stays and high mortality rates (19). Streptococci, staphylococci, and enterococci a