Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Timothy M Lohman"'
Publikováno v:
eLife, Vol 4 (2015)
Escherichia coli single-stranded (ss)DNA binding (SSB) protein mediates genome maintenance processes by regulating access to ssDNA. This homotetrameric protein wraps ssDNA in multiple distinct binding modes that may be used selectively in different D
Externí odkaz:
https://doaj.org/article/b7448e1a7dea47899245e8ff58cfaa57
Autor:
Sean P. Carney, Wen Ma, Kevin D. Whitley, Haifeng Jia, Timothy M. Lohman, Zaida Luthey-Schulten, Yann R. Chemla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
UvrD is a model helicase from the non-hexameric Superfamily 1. Here, the authors use optical tweezers to measure directly the stepwise translocation of UvrD along a DNA hairpin, and propose a mechanism in which UvrD moves one base pair at a time, but
Externí odkaz:
https://doaj.org/article/787da31e7c364e8b9f5fc0478dc6983b
Publikováno v:
Nucleic Acids Research. 51:2284-2297
Escherichia coli single stranded (ss) DNA binding protein (SSB) plays essential roles in DNA maintenance. It binds ssDNA with high affinity through its N-terminal DNA binding core and recruits at least 17 different SSB interacting proteins (SIPs) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7183d7b5ec17c7400a80667a3ac5f01
https://doi.org/10.1093/nar/gkad084
https://doi.org/10.1093/nar/gkad084
Autor:
Britney Johnson, Patrick McConnell, Alex G. Kozlov, Marlene Mekel, Timothy M. Lohman, Michael L. Gross, Gaya K. Amarasinghe, John A. Cooper
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2795-2804 (2018)
Actin assembly is important for cell motility. The ability of actin subunits to join or leave filaments via the barbed end is critical to actin dynamics. Capping protein (CP) binds to barbed ends to prevent subunit gain and loss and is regulated by p
Externí odkaz:
https://doaj.org/article/f8380583d0ab4e5ea1829184075c0d34
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Replication protein A (RPA) is a eukaryotic single-stranded (ss) DNA-binding (SSB) protein that is essential for all aspects of genome maintenance. RPA binds ssDNA with high affinity but can also diffuse along ssDNA. By itself, RPA is capable of tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0438ffaeaf71e72b7d863242e83d7079
https://doi.org/10.1073/pnas.2216777120
https://doi.org/10.1073/pnas.2216777120
Autor:
Haifeng Jia, Yann R. Chemla, Sean P. Carney, Zaida Luthey-Schulten, Timothy M. Lohman, Wen Ma, Kevin D. Whitley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
UvrD, a model for non-hexameric Superfamily 1 helicases, utilizes ATP hydrolysis to translocate stepwise along single-stranded DNA and unwind the duplex. Previous estimates of its step size have been indirect, and a consensus on its stepping mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a844ecdf4de680681b93d0ffd6d5c399
https://doaj.org/article/787da31e7c364e8b9f5fc0478dc6983b
https://doaj.org/article/787da31e7c364e8b9f5fc0478dc6983b
Publikováno v:
Biophysical Journal. 122:63a-64a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453f215dba22584a83f59bdcd86522fb
https://doi.org/10.1016/j.bpj.2022.11.551
https://doi.org/10.1016/j.bpj.2022.11.551
Publikováno v:
Nucleic Acids Research
Escherichia coli RecO is a recombination mediator protein that functions in the RecF pathway of homologous recombination, in concert with RecR, and interacts with E. coli single stranded (ss) DNA binding (SSB) protein via the last 9 amino acids of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328182e6310cfa77793691c05418b335
https://doi.org/10.1093/nar/gkaa1291
https://doi.org/10.1093/nar/gkaa1291
Autor:
Steven J. Sandler, Antoine M. van Oijen, Nicholas E. Dixon, Lisanne M. Spenkelink, James L. Keck, Alexander G. Kozlov, Michael M. Cox, Elizabeth A. Wood, Timothy M. Lohman, Katarzyna Dubiel, Slobodan Jergic, Camille Henry
Publikováno v:
Nucleic Acids Research
Bacterial single-stranded DNA-binding proteins (SSBs) bind single-stranded DNA and help to recruit heterologous proteins to their sites of action. SSBs perform these essential functions through a modular structural architecture: the N-terminal domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64bca514e517b9ed299927f5f7d68b4
https://doi.org/10.1093/nar/gkaa320
https://doi.org/10.1093/nar/gkaa320
Autor:
Ankita Chadda, Drake Jensen, Eric J. Tomko, Ana Ruiz Manzano, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Mycobacterium tuberculosis ( Mtb ) is an intracellular pathogen that causes tuberculosis and is exposed to oxidative insults from immune system macrophages. Mtb UvrD1 plays a role in DNA repair during infection and has been suggested to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8829f899785e925ee60f1e9377ec05b7
https://doi.org/10.1073/pnas.2114501119
https://doi.org/10.1073/pnas.2114501119