Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Timothy M Johanson"'
Autor:
Timothy M Johanson, Hannah D Coughlan, Aaron T L Lun, Naiara G Bediaga, Gaetano Naselli, Alexandra L Garnham, Leonard C Harrison, Gordon K Smyth, Rhys S Allan
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007431 (2018)
It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination. Here we aimed to identify novel transchromosomal interac
Externí odkaz:
https://doaj.org/article/45da5c743d81473eb4350b4219b44f50
Autor:
Nicole A Siddall, Marina Kalcina, Timothy M Johanson, Adrian C Monk, Franca Casagranda, Reeva P Been, Eileen A McLaughlin, Gary R Hime
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49810 (2012)
The vertebrate RNA-binding proteins, Musashi-1 (Msi-1) and Musashi-2 (Msi-2) are expressed in multiple stem cell populations. A role for Musashi proteins in preventing stem cell differentiation has been suggested from genetic analysis of the Drosophi
Externí odkaz:
https://doaj.org/article/2e340dc006ac42848fa5e0e08ce65ebc
Autor:
Andres Tapia del Fierro, Bianca den Hamer, Natalia Benetti, Natasha Jansz, Kelan Chen, Tamara Beck, Hannah Vanyai, Alexandra D. Gurzau, Lucia Daxinger, Shifeng Xue, Thanh Thao Nguyen Ly, Iromi Wanigasuriya, Megan Iminitoff, Kelsey Breslin, Harald Oey, Yvonne D. Krom, Dinja van der Hoorn, Linde F. Bouwman, Timothy M. Johanson, Matthew E. Ritchie, Quentin A. Gouil, Bruno Reversade, Fabrice Prin, Timothy Mohun, Silvère M. van der Maarel, Edwina McGlinn, James M. Murphy, Andrew Keniry, Jessica C. de Greef, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity at endogenous developmental ta
Externí odkaz:
https://doaj.org/article/4b268abe87144921872eecf80d018c13
Autor:
Nicole A. Siddall, Franca Casagranda, Timothy M. Johanson, Nicole Dominado, James Heaney, Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract The Drosophila ovary is regenerated from germline and somatic stem cell populations that have provided fundamental conceptual understanding on how adult stem cells are regulated within their niches. Recent ovarian transcriptomic studies have
Externí odkaz:
https://doaj.org/article/6acfb8dca3684d6ea54482be0bd08dc7
Autor:
Wing Fuk Chan, Hannah D. Coughlan, Yunshun Chen, Christine R. Keenan, Gordon K. Smyth, Andrew C. Perkins, Timothy M. Johanson, Rhys S. Allan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.
Externí odkaz:
https://doaj.org/article/aa28af5f1a0d4589a6f38a6f04cab4f2
Autor:
Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson
Publikováno v:
Immunology & Cell Biology. 101:345-357
Autor:
Christine R. Keenan, Michael J. Mlodzianoski, Hannah D. Coughlan, Naiara G. Bediaga, Gaetano Naselli, Erin C. Lucas, Qike Wang, Carolyn A. de Graaf, Douglas J. Hilton, Leonard C. Harrison, Gordon K. Smyth, Kelly L. Rogers, Thomas Boudier, Rhys S. Allan, Timothy M. Johanson
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102161- (2021)
Summary: The proximity pattern and radial distribution of chromosome territories within spherical nuclei are random and non-random, respectively. Whether this distribution pattern is conserved in the partitioned or lobed nuclei of polymorphonuclear c
Externí odkaz:
https://doaj.org/article/4507fe55d6fe45d69a3ecca9fe7b35b9
Publikováno v:
Molecular Immunology. 133:53-62
T cells can be subdivided into a number of different subsets that are defined by their distinct functions. While the specialization of different T cell subsets is partly achieved by the expression of specific genes, the overall transcriptional profil
Autor:
Timothy M, Johanson, Rhys S, Allan
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2458
In situ HiC uses the relative frequency of DNA-DNA ligation events to reconstruct the three-dimensional architecture of a genome. As such, restriction enzyme digested ends of genomic DNA within fixed nuclei are tagged with biotinylated dNTPs. DNA-DNA
Autor:
Rhys S. Allan, Naiara G. Bediaga, Gaetano Naselli, Timothy M. Johanson, Leonard C. Harrison, Nadia Iannarella, Christine R. Keenan
Publikováno v:
Blood. 135:2049-2058
Loss of heterochromatin has been proposed as a universal mechanism of aging across different species and cell types. However, a comprehensive analysis of hematopoietic changes caused by heterochromatin loss is lacking. Moreover, there is conflict in