Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Timothy M D, Ebbels"'
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-26 (2022)
Abstract Background Single sample pathway analysis (ssPA) transforms molecular level omics data to the pathway level, enabling the discovery of patient-specific pathway signatures. Compared to conventional pathway analysis, ssPA overcomes the limitat
Externí odkaz:
https://doaj.org/article/ca928c1770874377b4191919333add42
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background The search for statistically significant relationships between molecular markers and outcomes is challenging when dealing with high-dimensional, noisy and collinear multivariate omics data, such as metabolomic profiles. Permutatio
Externí odkaz:
https://doaj.org/article/a13f496b4c1e45deac76c05ae1366c04
Autor:
Takoua Jendoubi, Timothy M. D. Ebbels
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Metabolomics time-course experiments provide the opportunity to understand the changes to an organism by observing the evolution of metabolic profiles in response to internal or external stimuli. Along with other omic longitudinal
Externí odkaz:
https://doaj.org/article/e93421f3cc414b809d46cc730ed84c42
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Transcriptomic data is often used to build statistical models which are predictive of a given phenotype, such as disease status. Genes work together in pathways and it is widely thought that pathway representations will be more ro
Externí odkaz:
https://doaj.org/article/214ae9cfec0c4d23b913d99dae08d675
Autor:
Mark R. Viant, Timothy M. D. Ebbels, Richard D. Beger, Drew R. Ekman, David J. T. Epps, Hennicke Kamp, Pim E. G. Leonards, George D. Loizou, James I. MacRae, Bennard van Ravenzwaay, Philippe Rocca-Serra, Reza M. Salek, Tilmann Walk, Ralf J. M. Weber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important application
Externí odkaz:
https://doaj.org/article/4701db2695034f70a507e741b7841422
Autor:
Chung-Ho E. Lau, Victoria Taylor-Bateman, Panagiotis A. Vorkas, Gonçalo Graça, Thanh-Huyen T. Vu, Lifang Hou, Elena Chekmeneva, Timothy M. D. Ebbels, Queenie Chan, Linda Van Horn, Elaine Holmes
Publikováno v:
Metabolites, Vol 10, Iss 12, p 498 (2020)
Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling i
Externí odkaz:
https://doaj.org/article/493a5615efc245f8a6a19720884b5380
Autor:
Sei Harada, Akiyoshi Hirayama, Queenie Chan, Ayako Kurihara, Kota Fukai, Miho Iida, Suzuka Kato, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Miki Akiyama, Tomonori Okamura, Timothy M D Ebbels, Paul Elliott, Masaru Tomita, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Toru Takebayashi
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191230 (2018)
Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enroll
Externí odkaz:
https://doaj.org/article/f831682c48194fea9d9c775b0b1a4767
Autor:
Elaine Holmes, Johan Trygg, Timothy M. D. Ebbels, Matthew R. Lewis, Jeremy K. Nicholson, Caroline Sands, Benjamin J. Blaise, Izabella Surowiec, Jake T M Pearce, Gonçalo D S Correia, Gordon A Haggart
Publikováno v:
Nature Protocols. 16:4299-4326
Metabolic phenotyping is an important tool in translational biomedical research. The advanced analytical technologies commonly used for phenotyping, including mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, generate complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a835b00350461c940f7a2d3825de94
https://doi.org/10.1038/s41596-021-00579-1
https://doi.org/10.1038/s41596-021-00579-1
The future of metabolomics in ELIXIR [version 2; referees: 2 approved, 1 approved with reservations]
Autor:
Merlijn van Rijswijk, Charlie Beirnaert, Christophe Caron, Marta Cascante, Victoria Dominguez, Warwick B. Dunn, Timothy M. D. Ebbels, Franck Giacomoni, Alejandra Gonzalez-Beltran, Thomas Hankemeier, Kenneth Haug, Jose L. Izquierdo-Garcia, Rafael C. Jimenez, Fabien Jourdan, Namrata Kale, Maria I. Klapa, Oliver Kohlbacher, Kairi Koort, Kim Kultima, Gildas Le Corguillé, Pablo Moreno, Nicholas K. Moschonas, Steffen Neumann, Claire O’Donovan, Martin Reczko, Philippe Rocca-Serra, Antonio Rosato, Reza M. Salek, Susanna-Assunta Sansone, Venkata Satagopam, Daniel Schober, Ruth Shimmo, Rachel A. Spicer, Ola Spjuth, Etienne A. Thévenot, Mark R. Viant, Ralf J. M. Weber, Egon L. Willighagen, Gianluigi Zanetti, Christoph Steinbeck
Publikováno v:
F1000Research, Vol 6 (2017)
Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe,
Externí odkaz:
https://doaj.org/article/c94085c689b54380a553c8703294e419
The future of metabolomics in ELIXIR [version 1; referees: 2 approved, 1 approved with reservations]
Autor:
Merlijn van Rijswijk, Charlie Beirnaert, Christophe Caron, Marta Cascante, Victoria Dominguez, Warwick B. Dunn, Timothy M. D. Ebbels, Franck Giacomoni, Alejandra Gonzalez-Beltran, Thomas Hankemeier, Kenneth Haug, Jose L. Izquierdo-Garcia, Rafael C. Jimenez, Fabien Jourdan, Namrata Kale, Maria I. Klapa, Oliver Kohlbacher, Kairi Koort, Kim Kultima, Gildas Le Corguillé, Nicholas K. Moschonas, Steffen Neumann, Claire O’Donovan, Martin Reczko, Philippe Rocca-Serra, Antonio Rosato, Reza M. Salek, Susanna-Assunta Sansone, Venkata Satagopam, Daniel Schober, Ruth Shimmo, Rachel A. Spicer, Ola Spjuth, Etienne A. Thévenot, Mark R. Viant, Ralf J. M. Weber, Egon L. Willighagen, Gianluigi Zanetti, Christoph Steinbeck
Publikováno v:
F1000Research, Vol 6 (2017)
Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe,
Externí odkaz:
https://doaj.org/article/7ec37540efbd4035ab14e9d3c1f69f4d