Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Timothy M, Shoup"'
Autor:
Felicitas J. Detmer, Nathaniel M. Alpert, Sung-Hyun Moon, Maeva Dhaynaut, J. Luis Guerrero, Nicolas J. Guehl, Fangxu Xing, Pedro Brugarolas, Timothy M. Shoup, Marc D. Normandin, Matthieu Pelletier-Galarneau, Georges El Fakhri, Yoann Petibon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this proof-of-principle study, we investigated whether PET mapping of cardiac membrane potential, an indicator of mitochondrial function, could detect
Externí odkaz:
https://doaj.org/article/45f72c7eae84477dbaf9f917eb1916ed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Neurodegenerative diseases are characterized by chronic neuroinflammation and may perpetuate ongoing fibrotic reactions within the central nervous system. Unfortunately, there is no therapeutic available that treats neurodegenerative inflamm
Externí odkaz:
https://doaj.org/article/e2328ab4abee4ebfb166ab93580cbe93
Autor:
Junfeng Wang, Sung‐Hyun Moon, Michael B. Cleary, Timothy M. Shoup, Georges El Fakhri, Zhaoda Zhang, Anna‐Liisa Brownell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 66:34-40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462a46f12d8021bf9fa27069da5e60cd
https://doi.org/10.1002/jlcr.4011
https://doi.org/10.1002/jlcr.4011
Autor:
Carmen Priolo, Marc D. Normandin, Georges El Fakhri, Marie F. Kijewski, William M. Oldham, Peter M. Sadow, Souheil El-Chemaly, Ye Cui, Walter Massefski, Chongzhao Ran, Nicolas J. Guehl, Jing Yang, Ramesh Neelamegam, Timothy M. Shoup, Shuyan Wang, Kazue Takahashi, You Feng, William J. Mischler, Taylor R. Kavanagh, Eline E. Verwer
[18F]FCH uptake in TSC2-deficient cells in vivo after 72-hr exposure to vehicle control (two representative mice).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0fbeed7968f98ce07f40351b3f298b
https://doi.org/10.1158/1078-0432.22469585.v1
https://doi.org/10.1158/1078-0432.22469585.v1
Autor:
Carmen Priolo, Marc D. Normandin, Georges El Fakhri, Marie F. Kijewski, William M. Oldham, Peter M. Sadow, Souheil El-Chemaly, Ye Cui, Walter Massefski, Chongzhao Ran, Nicolas J. Guehl, Jing Yang, Ramesh Neelamegam, Timothy M. Shoup, Shuyan Wang, Kazue Takahashi, You Feng, William J. Mischler, Taylor R. Kavanagh, Eline E. Verwer
Summary of FCH and FACE Imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44817273faf1d72572e54bea0c0bc6a9
https://doi.org/10.1158/1078-0432.22469561.v1
https://doi.org/10.1158/1078-0432.22469561.v1
Autor:
Gengyang Yuan, Maeva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Hao Wang, Sung-Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, Georges El Fakhri, Marc D. Normandin, Anna-Liisa Brownell
Publikováno v:
Journal of Medicinal Chemistry. 65:2593-2609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8e34ca763a7812a60b53acd65dc8c1f
https://doi.org/10.1021/acs.jmedchem.1c02004
https://doi.org/10.1021/acs.jmedchem.1c02004
Autor:
Gengyang, Yuan, Maeva, Dhaynaut, Yu, Lan, Nicolas J, Guehl, Dalena, Huynh, Suhasini M, Iyengar, Sepideh, Afshar, Manish Kumar, Jain, Julie E, Pickett, Hye Jin, Kang, Hao, Wang, Sung-Hyun, Moon, Mary Jo, Ondrechen, Changning, Wang, Timothy M, Shoup, Georges, El Fakhri, Marc D, Normandin, Anna-Liisa, Brownell
Publikováno v:
J Med Chem
Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by positron emission tomography (PET). In this regard, 5-(2-fluoro-4-[(11)C]methoxyphenyl)-2,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::704c966f7f2686c685beaf9baccb53b1
https://pubmed.ncbi.nlm.nih.gov/35089713
https://pubmed.ncbi.nlm.nih.gov/35089713
Autor:
Junfeng, Wang, Sung-Hyun, Moon, Michael B, Cleary, Timothy M, Shoup, Georges, El Fakhri, Zhaoda, Zhang, Anna-Liisa, Brownell
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals.
We report here the detailed radiosynthesis of [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b9c4028f5cdb7f13f4d03a8a6f87bbd
https://pubmed.ncbi.nlm.nih.gov/36593743
https://pubmed.ncbi.nlm.nih.gov/36593743
Autor:
Nathaniel M Alpert, Nicolas Guehl, Leon Ptaszek, Matthieu Pelletier-Galarneau, Jeremy Ruskin, Moussa C Mansour, Dustin Wooten, Chao Ma, Kazue Takahashi, Yun Zhou, Timothy M Shoup, Marc D Normandin, Georges El Fakhri
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190968 (2018)
Mitochondrial membrane potential (ΔΨm) arises from normal function of the electron transport chain. Maintenance of ΔΨm within a narrow range is essential for mitochondrial function. Methods for in vivo measurement of ΔΨm do not exist. We use 18
Externí odkaz:
https://doaj.org/article/9d0e2238feb24e7595795abcfe4d4e11
Autor:
Marc D. Normandin, Timothy M. Shoup, Pedro Brugarolas, Georges El Fakhri, David R. Elmaleh, Luisa Quinti, Ana Griciuc, Maeva Dhaynaut, Sung-Hyun Moon, Rudolph E. Tanzi, Nicolas Guehl, Lindsay V Walsh
Publikováno v:
Journal of Alzheimer's Disease. 80:775-786
Background: Cromolyn is an anti-neuroinflammatory modulator with a multifactorial mechanism of action that has been shown to inhibit amyloid-β (Aβ) aggregation and enhance microglial uptake and clearance of Aβ. Objective: We report the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb25bd22d8325e9017c8942612923609
https://doi.org/10.3233/jad-201419
https://doi.org/10.3233/jad-201419